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TRPC6 gene variants and neuropsychiatric lupus
Journal of Neuroimmunology, 2015Neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE) influence patients' quality of life and their survival. Little is known about the pathophysiological bases of NPSLE and accordingly there are no specific therapeutic agents to be employed in this setting. Genetic research in systemic lupus erythematosus (SLE) is rapidly evolving as
Ramirez GA +10 more
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The possible role of TRPC6 in atopic dermatitis
Medical Hypotheses, 2012Skin barrier dysfunction is involved in the pathogenesis of atopic dermatitis (AD). The impaired barrier function is related to disturbed keratinocyte differentiation through improper Ca2+-regulated pathway in AD. Transient receptor potential canonical (subtype) 6 (TRPC6) is a Ca2+-permeable nonselective cation channel expressed in keratinocytes. TRPC6
Xiao-Dong, Sun +6 more
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Immunohistochemical localization of TRPC6 in the rat substantia nigra
Neuroscience Letters, 2007Transient receptor potential channels (TRPC) are plasma membrane, nonselective cationic channels and have been proposed as candidates involved in the regulation of cellular Ca2+ influx [D.E. Clapham, L.W. Runnels, C., Strubing, The TRP ion channel family, Nat. Rev. Neurosci. 2 (2001) 387-396; A. Martorana, C. Giampa, Z. DeMarch, M.T.
Giampà C +4 more
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TRPC6: Physiological Function and Pathophysiological Relevance
2014TRPC6 is a non-selective cation channel 6 times more permeable to Ca(2+) than to Na(+). Channel homotetramers heterologously expressed have a characteristic doubly rectifying current-voltage relationship and are directly activated by the second messenger diacylglycerol (DAG).
Alexander, Dietrich, Thomas, Gudermann
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STIM1 regulates TRPC6 heteromultimerization and subcellular location
Biochemical Journal, 2014STIM1 (stromal interaction molecule 1) regulates store-operated channels in the plasma membrane, but the regulation of TRPC (transient receptor potential canonical) heteromultimerization and location by STIM1 is poorly understood. STIM1 is a single transmembrane protein that communicates the filling state of the endoplasmic reticulum to store-operated ...
Letizia, Albarrán +5 more
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Targeting TRPC6 channels in oesophageal carcinoma growth
Expert Opinion on Therapeutic Targets, 2010Oesophageal carcinoma ranks among the ten most frequent cancers worldwide. The special growing site and malignant nature make it difficult to be completely treated by surgical operation and radiotherapy or chemotherapy. Discovery of new therapeutic targets responsible for the rapid proliferation of oesophageal carcinoma cells could help to treat this ...
Xia, Ding +4 more
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Role of TRPC6 channel in eosinophil function
European Respiratory Journal, 2013[ Objective ] Calcium homeostasis plays a key role in the regulation of many functional responses such as degranulation, lipid mediator release in airway inflammatory cells, including eosinophils.
Akiko Sano +3 more
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TRPC6 channel and its implications in breast cancer: an overview
Biochimica Et Biophysica Acta - Molecular Cell Research, 2020Gines M Salido +2 more
exaly
Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior
International Journal of Molecular Sciences, 2023Elena Popugaeva, Nikita Zernov
exaly