Results 51 to 60 of about 6,014 (173)

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Involvement of Rab9 and Rab11 in the intracellular trafficking of TRPC6

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2010
TRPC proteins become involved in Ca2+ entry following the activation of Gq-protein coupled receptors. TRPC6 is inserted into the plasma membrane upon stimulation and remains in the plasma membrane as long as the stimulus is present. However, the mechanism that regulates the trafficking of TRPC6 is unclear.
Cayouette, Sylvie, Bousquet, Simon M., Francoeur, Nancy, Dupré, Émilie, Monet, Michaël, Gagnon, Hugo, Guedri, Youssef B., Lavoie, Christine, Boulay, Guylain   +8 more
openaire   +2 more sources

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice

Scientific Reports, 2017
Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive ...
Sayaka Oda, Takuro Numaga-Tomita, Naoyuki Kitajima, Takashi Toyama, Eri Harada, Tsukasa Shimauchi, Akiyuki Nishimura, Tatsuya Ishikawa, Yoshito Kumagai, Lutz Birnbaumer, Motohiro Nishida   +10 more
doaj   +1 more source

TRPC6-mediated ERK1/2 Activation Regulates Neuronal Excitability via Subcellular Kv4.3 Localization in the Rat Hippocampus

Frontiers in Cellular Neuroscience, 2017
Recently, we have reported that transient receptor potential channel-6 (TRPC6) plays an important role in the regulation of neuronal excitability and synchronization of spiking activity in the dentate granule cells (DGC).
Ji-Eun Kim, Jin-Young Park, Tae-Cheon Kang   +2 more
doaj   +1 more source

Klotho Ameliorates Podocyte Injury through Targeting TRPC6 Channel in Diabetic Nephropathy

Journal of Diabetes Research, 2022
Podocyte damage is vital for the etiopathogenesis of diabetic nephropathy (DN). Klotho (KL), a multifunctional protein, has been demonstrated to have renoprotective effects; nevertheless, the mechanism for protective effect has not been completely ...
Xingmei Yao, Hengjiang Guo, Mengyao Sun, Sixuan Meng, Bingbing Zhu, Ji Fang, Jiebo Huang, Hao Wang, Lina Xing   +8 more
doaj   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

The TRPC6-AMPK Pathway is Involved in Insulin-Dependent Cytoskeleton Reorganization and Glucose Uptake in Cultured Rat Podocytes

Cellular Physiology and Biochemistry, 2018
Background/Aims: Podocytes are dynamic polarized cells on the surface of glomerular capillaries that are an essential part of the glomerular filtration barrier.
Patrycja Rachubik, Maria Szrejder, Dorota Rogacka, Irena Audzeyenka, Michał Rychłowski, Stefan Angielski, Agnieszka  Piwkowska   +6 more
doaj   +1 more source

The Role of TRPC6 in Renal Ischemia/Reperfusion and Cellular Hypoxia/Reoxygenation Injuries

Frontiers in Molecular Biosciences, 2021
Renal ischemia/reperfusion (I/R), a major cause of acute kidney injury (AKI), is a serious clinical event in patients during post-renal transplantation. I/R is associated with renal dysfunction and tubular apoptosis, and calcium (Ca2+) overload has been ...
Xin Hou, Mengjun Huang, Xixi Zeng, Yanhong Zhang, Anbang Sun, Qifang Wu, Lin Zhu, Hu Zhao, Yanhong Liao   +8 more
doaj   +1 more source

Functional Role of Piezo1 in Regulating Whole‐Lung Vascular Reactivity

Pulmonary Circulation, Volume 16, Issue 3, July 2026.
ABSTRACT Mechanosensitive cation channels expressed in pulmonary arterial smooth muscle (SMC) and endothelial (EC) cells contribute to the regulation of vasoconstriction and vasodilation of the pulmonary vasculature. Here, we report that activating Piezo1, a mechanosensitive cation channel, with Yoda1 induced a mild increase in pulmonary arterial ...
Sophia Parmisano, Jiyuan Chen, Yuqin Chen, Pritesh P. Jain, Lauren Yung, Wei‐Ting Wang, Ting Wang, Xiang Li, Angela Balistrieri, Sophia A. Ferrizzi, Cassia Pedron, Owen Brooks, Mona Alotaibi, Jian Wang, Joe G.N. Garcia, Patricia A. Thistlethwaite, Ayako Makino, Jason X.‐J. Yuan   +17 more
wiley   +1 more source