Results 31 to 40 of about 7,679 (208)

Inhibition of native TRPC6 channel activity by phosphatidylinositol 4,5-bisphosphate in mesenteric artery myocytes [PDF]

, 2008
The present work investigates the effect of phosphatidylinositol-4,5-bisphosphate (PIP2) on native TRPC6 channel activity in freshly dispersed rabbit mesenteric artery myocytes using patch clamp recording and co-immunoprecipitation methods.
Saleh, Sohag N., Albert, Anthony P., Large, William A., Large, WA, Saleh, SN, Albert, AP   +5 more
core   +1 more source

Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation [PDF]

, 2011
Psoriasis is a characteristic inflammatory and scaly skin condition with typical histopathological features including increased proliferation and hampered differentiation of keratinocytes.
Ute Woelfle, Kristina Leuner, Schempp, Christoph M., Kraus, Margarethe, Walter E Müller, Harteneck Christian, Christoph M. Schempp, Walter E. Müller, Margarethe Kraus, Harteneck, Christian, Beschmann, Heike, Beschmann, Heike A., Boehncke, Wolf-Henning, Beschmann Heike, Boehncke Wolf-Henning, Schempp Christoph M., Kraus Margarethe, Christoph M Schempp, Schempp, Christoph Mathis, Wolf-Henning Boehncke, Heike Beschmann, Christian Harteneck, Woelfle Ute, Leuner Kristina, Leuner, Kristina, Wölfle, Ute, Müller Walter E., Woelfle, Ute, Müller, Walter E.   +28 more
core   +1 more source

Modulation of Calcium Transients in Cardiomyocytes by Transient Receptor Potential Canonical 6 Channels

Frontiers in Physiology, 2020
Transient receptor potential canonical 6 (TRPC6) channels are non-selective cation channels that are thought to underlie mechano-modulation of calcium signaling in cardiomyocytes.
Azmi A. Ahmad, Azmi A. Ahmad, Molly E. Streiff, Molly E. Streiff, Chris Hunter, Frank B. Sachse, Frank B. Sachse   +6 more
doaj   +1 more source

TRPC6-Mediated Ca2+ Signaling is Required for Hypoxia-Induced Autophagy in Human Podocytes

Cellular Physiology and Biochemistry, 2018
Background/Aims: Intracellular Ca2+ signaling plays an important role in the regulation of autophagy. However, very little is known about the role of Ca2+ influx, which is induced by plasma membrane Ca2+ channels. Our previous study showed that transient
Tianrong Ji, Chengwei Zhang, Linlin Ma, Qin Wang, Li Zou, Kexin Meng, Rui Zhang, Jundong Jiao   +7 more
doaj   +1 more source

Increased glomerular filtration rate and impaired contractile function of mesangial cells in TRPC6 knockout mice

Scientific Reports, 2017
The present study was conducted to determine if TRPC6 regulates glomerular filtration rate (GFR) and the contractile function of glomerular mesangial cells (MCs).
Weizu Li, Yanfeng Ding, Crystal Smedley, Yanxia Wang, Sarika Chaudhari, Lutz Birnbaumer, Rong Ma   +6 more
doaj   +1 more source

The role of TRPC6 in kidney damage [PDF]

, 2023
Acute kidney injury (AKI) and chronic kidney disease (CKD) are worldwide common cause of death, strongly increases the risk of cardiovascular disease, and associated with a substantial economic burden. Severe AKI can progress to CKD.
Zheng, Zhihuang
core   +1 more source

The Role of Transient Receptor Potential Channel 6 Channels in the Pulmonary Vasculature

Frontiers in Immunology, 2017
Canonical or classical transient receptor potential channel 6 (TRPC6) is a Ca2+-permeable non-selective cation channel that is widely expressed in the heart, lung, and vascular tissues.
Monika Malczyk, Alexandra Erb, Christine Veith, Hossein Ardeschir Ghofrani, Ralph T. Schermuly, Thomas Gudermann, Alexander Dietrich, Norbert Weissmann, Akylbek Sydykov   +8 more
doaj   +1 more source

Inhibition of diacylglycerol–sensitive TRPC channels by synthetic and natural steroids [PDF]

, 2012
TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca2+ signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition have ...
Kleemann, Heinz-Werner, Rütten, Hartmut, Hartmut Rütten (171202), Löhn Matthias, Thorsten Schmidt (5598), Thomas Licher (171199), Löhn, Matthias, Miehe Susanne, Dittrich Werner, Peter Crause, Carsten Strübing (171204), Schmidt, Thorsten, Miehe, Susanne, Susanne Miehe, Schmidt Thorsten, Carsten Strübing, Heinz-Werner Kleemann (171197), Peter Crause (171193), Dittrich, Werner, Licher, Thomas, Hartmut Rütten, Matthias Löhn, Strübing, Carsten, Rütten Hartmut, Matthias Löhn (171195), Strübing Carsten, Werner Dittrich, Licher Thomas, Thomas Licher, Heinz-Werner Kleemann, Werner Dittrich (171200), Kleemann Heinz-Werner, Crause, Peter, Susanne Miehe (171189), Crause Peter, Thorsten Schmidt   +35 more
core   +2 more sources

Mechanosensitivity of TRPC6 Ion Channels [PDF]

Biophysical Journal, 2015
The transient receptor potential (TRP) ion channel family is a diverse group of channels gated by various physical and chemical stimuli. One of the members, transient receptor potential canonical-6 (TRPC6), is a calcium permeable cation channel (PCa/PNa ∼ 6) located in the T-tubules of ventricular cardiomyocytes.
Nikolaev, Yury A., Rohde, Paul R., Cox, Charles D., Laver, Derek R., Martinac, Boris   +4 more
openaire   +1 more source

An inactivating human TRPC6 channel mutation without focal segmental glomerulosclerosis

, 2023
Transient receptor potential cation channel-6 (TRPC6) gene mutations cause familial focal segmental glomerulosclerosis (FSGS), which is inherited as an autosomal dominant disease.
Kaßmann, Mario, Hariharan, Krithika, Gollasch, Maik, Krithika Hariharan, Gossen, Manfred, Sylvia Kaden, Kaden, Sylvia, Dmitry Tsvetkov, Maik Gollasch, Xu, Yao, Tsvetkov, Dmitry, Mario Kaßmann, Manfred Gossen, Lilas Batool, Gohlke, Björn-Oliver, Kurtz, Andreas, Bernd Nürnberg, Nürnberg, Bernd, Yao Xu, Björn-Oliver Gohlke, Andreas Kurtz, Batool, Lilas   +21 more
core   +2 more sources