Results 31 to 40 of about 6,014 (173)

Role of TRPC6 in periodontal tissue reconstruction mediated by appropriate stress

Stem Cell Research & Therapy, 2022
Introduction The basis of orthodontic tooth movement (OTM) is the reconstruction of periodontal tissue under stress. Increasing the speed of OTM has always been the focus of attention.
Li Wang, Hong Liang, Bingjing Sun, Jing Mi, Xianqin Tong, Yuhui Wang, Meihua Chen, Liming Yu, Jie Pan, Shangfeng Liu, Yan-Jun Liu, Yuehua Liu   +11 more
doaj   +1 more source

Integration of Phosphoinositide- and Calmodulin-Mediated Regulation of TRPC6 [PDF]

Molecular Cell, 2007
Multiple TRP channels are regulated by phosphoinositides (PIs). However, it is not known whether PIs bind directly to TRP channels. Furthermore, the mechanisms through which PIs regulate TRP channels are obscure. To analyze the role of PI/TRP interactions, we used a biochemical approach, focusing on TRPC6.
Kwon, Young, Hofmann, Thomas, Montell, Craig   +2 more
openaire   +2 more sources

TRPC6 Is Found in Distinct Compartments of the Human Kidney

International Journal of Translational Medicine, 2022
In the context of renal proteinuric diseases, TRPC6 has been shown to play an important role in ultrafiltration associated with the slit diaphragm through the control of the intracellular Ca2+ concentration in the podocytes of glomeruli. However, to date,
Colya N. Englisch, Daniel Röhricht, Mariesa Walz, Kerstin Junker, Anja Beckmann, Carola Meier, Friedrich Paulsen, Martin Jung, Thomas Tschernig   +8 more
doaj   +1 more source

Sensitizing the Slit Diaphragm with TRPC6 Ion Channels [PDF]

Journal of the American Society of Nephrology, 2009
Physiologic permeability of the glomerular capillary depends on the normal structure of podocyte foot processes forming a functioning slit diaphragm in between. Mutations in several podocyte genes as well as specific molecular pathways have been identified as the cause for progressive kidney failure with urinary protein loss.
Clemens C, Möller, Jan, Flesche, Jochen, Reiser   +2 more
openaire   +2 more sources

Genetic ablation of TRPC6 facilitated age-dependent atherosclerosis progression in an ApoE-/- mouse model

Frontiers in Physiology
BackgroundTRPC6 channels are expressed in endothelial cells, smooth muscle cells, and macrophages within the atherosclerotic segments of conduit blood vessels.
Isaac S. Demaree, Sreepadaarchana Munjuluri, Saketh Boyapalli, Regan E. Beaty, Dru A. Wilkerson, Sruthilatha Sakthi Velavan, Fletcher A. White, Alexander G. Obukhov   +7 more
doaj   +1 more source

TRPC6 Enhances Angiotensin II-induced Albuminuria [PDF]

Journal of the American Society of Nephrology, 2011
Mutations in the canonical transient receptor potential cation channel 6 (TRPC6) are responsible for familial forms of adult onset focal segmental glomerulosclerosis (FSGS). The mechanisms by which TRPC6 mutations cause kidney disease are not well understood. We used TRPC6-deficient mice to examine the function of TRPC6 in the kidney.
Eckel, Jason, Lavin, Peter J, Finch, Elizabeth A, Mukerji, Nirvan, Burch, Jarrett, Gbadegesin, Rasheed, Wu, Guanghong, Bowling, Brandy, Byrd, Alison, Hall, Gentzon, Sparks, Matthew, Zhang, Zhu Shan, Homstad, Alison, Barisoni, Laura, Birbaumer, Lutz, Rosenberg, Paul, Winn, Michelle P   +16 more
openaire   +3 more sources

TRPC6 mediates high glucose-induced mitochondrial fission through activation of CDK5 in cultured human podocytes

Frontiers in Physiology, 2022
Mitochondrial abnormalities contribute to the development of diabetic nephropathy (DN). However, the precise mechanisms of mitochondrial dysfunction in DN remain unclear.
Haomiao Yu, Yili Chen, Huimin Ma, Zihan Wang, Rui Zhang, Jundong Jiao, Jundong Jiao   +6 more
doaj   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Resolving a Complex Neonatal Phenotype by Rapid Trio Whole‐Genome Sequencing: A De Novo 11q14.3–q22.3 Deletion and a Splicing‐Altering Synonymous ANK1 Variant

Journal of Clinical Laboratory Analysis, EarlyView.
Clinical utility of trio WGS and time metrics in a neonate with congenital anomalies and hemolytic anemia. ABSTRACT Background Neonates with complex and evolving phenotypes often lack sufficiently specific clinical features to guide targeted genetic testing.
Hyun‐Woo Lee, Ja‐Hyun Jang, Beom Hee Lee, Hee‐Jeong Youk, Eun Sun Kim, Kee Hyun Cho, Yun Sil Chang, Heui Seung Jo, Mi‐Ae Jang   +8 more
wiley   +1 more source