Results 21 to 30 of about 6,014 (173)
TRPC3 Activation by Erythropoietin Is Modulated by TRPC6 [PDF]
Journal of Biological Chemistry, 2009 Regulation of intracellular calcium ([Ca(2+)](i)) by erythropoietin (Epo) is an essential part of signaling pathways controlling proliferation and differentiation of erythroid progenitors, but regulatory mechanisms are largely unknown. TRPC3 and the homologous TRPC6 are two members of the transient receptor potential channel (TRPC) superfamily that are
Iwona, Hirschler-Laszkiewicz +8 more
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Expression of trpC1 and trpC6 orthologs in zebrafish [PDF]
Gene Expression Patterns, 2008 Transient receptor potential (TRP) genes encode subunits that form cation-selective ion channels in a variety of organisms and cell types. TRP channels serve diverse functions ranging from thermal, tactile, taste, and osmolar sensing to fluid flow sensing.
Clemens C, Möller +3 more
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TRPC6-Mediated Ca2+ Signaling is Required for Hypoxia-Induced Autophagy in Human Podocytes
Cellular Physiology and Biochemistry, 2018 Background/Aims: Intracellular Ca2+ signaling plays an important role in the regulation of autophagy. However, very little is known about the role of Ca2+ influx, which is induced by plasma membrane Ca2+ channels. Our previous study showed that transient
Tianrong Ji +7 more
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Frontiers in Physiology, 2020 Transient receptor potential canonical 6 (TRPC6) channels are non-selective cation channels that are thought to underlie mechano-modulation of calcium signaling in cardiomyocytes.
Azmi A. Ahmad +6 more
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Scientific Reports, 2017 The present study was conducted to determine if TRPC6 regulates glomerular filtration rate (GFR) and the contractile function of glomerular mesangial cells (MCs).
Weizu Li +6 more
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The Role of Transient Receptor Potential Channel 6 Channels in the Pulmonary Vasculature
Frontiers in Immunology, 2017 Canonical or classical transient receptor potential channel 6 (TRPC6) is a Ca2+-permeable non-selective cation channel that is widely expressed in the heart, lung, and vascular tissues.
Monika Malczyk +8 more
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TRPC6 and FSGS: The latest TRP channelopathy
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007 Focal and segmental glomerulosclerosis (FSGS) is a common cause of nephrotic syndrome in children and adults throughout the world. In the past 50 years, significant advances have been made in the identification and characterization of familial forms of nephrotic syndrome and FSGS.
Mukerji, Nirvan +2 more
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Mechanosensitivity of TRPC6 Ion Channels [PDF]
Biophysical Journal, 2015 The transient receptor potential (TRP) ion channel family is a diverse group of channels gated by various physical and chemical stimuli. One of the members, transient receptor potential canonical-6 (TRPC6), is a calcium permeable cation channel (PCa/PNa ∼ 6) located in the T-tubules of ventricular cardiomyocytes.
Nikolaev, Yury A. +4 more
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JVS - Vascular Science, 2020 Objective: Previous studies showed the benefit of canonical transient receptor potential 6 (TRPC6) channel deficiency in promoting endothelial healing of arterial injuries in hypercholesterolemic animals. Long-term studies utilizing a carotid wire-injury
Andrew H. Smith, MD +6 more
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Activation of Human TRPC6 Channels by Receptor Stimulation [PDF]
Journal of Biological Chemistry, 2004 The human TRPC6 channel was expressed in human embryonic kidney (HEK) cells, and activity was monitored using the giga-seal technique. Whole cell membrane currents with distinctive inward and outward rectification were activated by carbachol (CCh) in TRPC6-expressing cells, but not in lacZ-transfected controls.
Mark, Estacion +7 more
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