Results 21 to 30 of about 7,679 (208)

Role of TRPC6 in kidney damage after acute ischemic kidney injury

Scientific Reports, 2022
Transient receptor potential channel subfamily C, member 6 (TRPC6), a non-selective cation channel that controls influx of Ca2+ and other monovalent cations into cells, is widely expressed in the kidney.
Zhihuang Zheng, Dmitry Tsvetkov, Theda Ulrike Patricia Bartolomaeus, Cem Erdogan, Ute Krügel, Johanna Schleifenbaum, Michael Schaefer, Bernd Nürnberg, Xiaoning Chai, Friedrich-Alexander Ludwig, Gabriele N’diaye, May-Britt Köhler, Kaiyin Wu, Maik Gollasch, Lajos Markó   +14 more
doaj   +1 more source

TRPC6 Inactivation Reduces Albuminuria Induced by Protein Overload in Sprague Dawley Rats

Cells, 2022
Canonical transient receptor potential-6 (TRPC6) channels have been implicated in familial and acquired forms of focal and segmental glomerulosclerosis (FSGS), and in renal fibrosis following ureteral obstruction in mice.
Eun Young Kim, Stuart E. Dryer
doaj   +1 more source

TRPC6 is altered in COVID-19 pneumonia

Chemico-Biological Interactions, 2022
In this Letter to the Editor supportive data were presented to a recent paper published in this journal reporting the involvement of TRP channels in COVID-19 pneumonia and its role for new therapies. Since gene expression of TRP channels was found in human lung tissues the protein was not being reported so far.
Gina Leidinger, Fidelis Flockerzi, Johannes Hohneck, Rainer M. Bohle, Armin Fieguth, Thomas Tschernig   +5 more
openaire   +2 more sources

Regulation of TRPC6 Podocyte Surface Expression by Synaptopodin [PDF]

, 2016
Mutations of classic Transient Receptor Potential Channel 6 (TRPC6) were identified in hereditary FSGS, most of which are gain-of function. Increased expression of wild-type TRPC6 in glomeruli was observed in several human acquired proteinuric diseases ...
Yu, Hao
core   +5 more sources

TRPC6 Attenuates Cortical Astrocytic Apoptosis and Inflammation in Cerebral Ischemic/Reperfusion Injury

Frontiers in Cell and Developmental Biology, 2021
Transient receptor potential canonical 6 (TRPC6) channel is an important non-selective cation channel with a variety of physiological roles in the central nervous system.
Lu Liu, Manli Chen, Kun Lin, Xuwu Xiang, Jing Yang, Yueying Zheng, Xiaoxing Xiong, Xiaoxing Xiong, Shengmei Zhu   +8 more
doaj   +1 more source

Transient receptor potential canonical 6 knockdown ameliorated diabetic kidney disease by inhibiting nuclear factor of activated T cells 2 expression in glomerular mesangial cells

Renal Failure, 2022
Purpose Glomerular mesangial cell (GMC) dysfunction plays a vital role in the pathogenesis of diabetic kidney disease (DKD). Transient receptor potential canonical 6 (TRPC6) has been demonstrated to be involved in the development of DKD.
Jian Yu, Chunchun Li, Lisha Ma, Bin Zhai, Aiping Xu, Decui Shao   +5 more
doaj   +1 more source

Elderly with Varying Extents of Cardiac Disease Show Interindividual Fluctuating Myocardial TRPC6-Immunoreactivity

Journal of Cardiovascular Development and Disease, 2023
Both particular myocardial locations in the human heart and the canonical transient receptor potential 6 (TRPC6) cation channel have been linked with cardiac pathophysiologies.
Jan Michael Federspiel, Jil Gartner, Peter Lipp, Peter Schmidt, Thomas Tschernig   +4 more
doaj   +1 more source

Expression of trpC1 and trpC6 orthologs in zebrafish [PDF]

Gene Expression Patterns, 2008
Transient receptor potential (TRP) genes encode subunits that form cation-selective ion channels in a variety of organisms and cell types. TRP channels serve diverse functions ranging from thermal, tactile, taste, and osmolar sensing to fluid flow sensing.
Clemens C, Möller, Steve, Mangos, Iain A, Drummond, Jochen, Reiser   +3 more
openaire   +2 more sources

TRPC3 Activation by Erythropoietin Is Modulated by TRPC6 [PDF]

Journal of Biological Chemistry, 2009
Regulation of intracellular calcium ([Ca(2+)](i)) by erythropoietin (Epo) is an essential part of signaling pathways controlling proliferation and differentiation of erythroid progenitors, but regulatory mechanisms are largely unknown. TRPC3 and the homologous TRPC6 are two members of the transient receptor potential channel (TRPC) superfamily that are
Iwona, Hirschler-Laszkiewicz, Qin, Tong, Kathleen, Conrad, Wenyi, Zhang, Wesley W, Flint, Alistair J, Barber, Dwayne L, Barber, Joseph Y, Cheung, Barbara A, Miller   +8 more
openaire   +2 more sources

Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice [PDF]

, 2012
Lung ischaemia–reperfusion-induced oedema (LIRE) is a life-threatening condition that causes pulmonary oedema induced by endothelial dysfunction. Here we show that lungs from mice lacking nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox2y/
Shah, Ajay M., Sydykov, Akylbek, Brandes, Ralf, Schermuly, Ralph T., Schnitzler, Michael Mederos y, Storch, Ursula, Brandes, Ralf P, Schermuly, Ralph T, Seeger, Werner, Shah, Ajay Mukesh, Veit, Florian, Dietrich, Alexander, Ghofrani, Hossein Ardeschir, Grimminger, Friedrich, Meissner, Marcel, Pak, Oleg, Brewer, Alison C.; id_orcid, Kalwa, Hermann, Offermanns, Stefan, Ghofrani, Hossein A., Schmidt, Harald H. H. W., Brewer, Alison C, Fuchs, Beate, Ghofrani, Hossein A, Mederos y Schnitzler, Michael, Shah, Ajay M, Krause, Karl-Heinz, Schmidt, Harald H.H.W., Weißmann, Norbert, Gudermann, Thomas, Brewer, Alison C., Schmidt, Harald H H W, Freichel, Marc, Brandes, Ralf P., Schermuly, Ralph Theo   +34 more
core   +1 more source