Results 61 to 70 of about 6,649 (159)

Pharmacological Differences between Native Homomeric Transient Receptor Potential Canonical Type 4 Channels and Heteromeric Transient Receptor Potential Canonical Type 1/4 Channels in Lateral Septal Neurons

Pharmaceuticals, 2023
Given the unique expression patterns and revelations of its critical involvement in a host of neurological disorders, the TRPC1/4/5 subgroup has become an intense target of drug development, and some compounds are now in clinical trials.
Kevin D. Phelan, U Thaung Shwe, Fang Zheng   +2 more
doaj   +1 more source

Neuroplasticity‐Driven Mechanisms and Therapeutic Targets in the Anterior Cingulate Cortex in Neuropathic Pain

Brain and Behavior, Volume 16, Issue 4, April 2026.
The anterior cingulate cortex (ACC), as the center for pain and emotion integration, causes integration disorders due to excessive synaptic strengthening and glial cell inflammation/synaptic pruning dysregulation. However, traditional drugs have insufficient targeting, and closed‐loop DBS improves symptoms by precisely regulating ACC.
Haibing Xiong, Letai Li, Yanlin Li, Yutong Chen, Jiajie Leng, Tingting Chen   +5 more
wiley   +1 more source

Reprogramming of Gene Transcripts and Metabolites by the Wild Soybean Endophyte Pseudomonas sp. 77S3 Improves Soybean Salt Tolerance

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2704-2721, April 2026.
ABSTRACT Soybean is a critical source of protein and vegetable oil worldwide. Expanding its cultivation into salinity lands represents a promising strategy for increasing production; however, soil salinity severely limits soybean growth by disrupting physiological and metabolic homeostasis.
Wanying Zhang, Chengyang Song, Tianqi Wang, Xiulin Liu, Yisheng Fang, Zhu Yan, Yaxi Zhu, Na Zheng, Xiaofei Ma, Guochen Qin, Dan Zhu, Junchuan Xiao, Xing Wang Deng, Xiao Luo   +13 more
wiley   +1 more source

TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer

Frontiers in Pharmacology
During the past half-century, although numerous interventions for obesity have arisen, the condition’s prevalence has relentlessly escalated annually. Obesity represents a substantial public health challenge, especially due to its robust correlation with
Yanting Lin, Rui Gao, Dongquan Jing, Yiming Liu, Huijuan Da, Lutz Birnbaumer, Lutz Birnbaumer, Yong Yang, Xinghua Gao, Zhenhua Gao, Zhenhua Gao, Qiuhua Cao, Qiuhua Cao   +12 more
doaj   +1 more source

In the gravid human uterus, oxytocin induces smooth muscle cell contraction via transient receptor potential vanilloid 4 channel activation

The Journal of Physiology, Volume 604, Issue 7, Page 3135-3158, 1 April 2026.
Abstract figure legend In gravid human uterus smooth muscle, the oxytocin receptor (OXTR) and transient receptor potential vanilloid 4 (TRPV4) calcium channel colocalize at <40 nm by proximity ligation. TRPV4 is necessary for oxytocin‐induced calcium influx and contractility in uterine smooth muscle cells.
Daiana Fornes, Jessica R. Ansari, Guillermina Michel, Cristina M. Alvira, David N. Cornfield   +4 more
wiley   +1 more source

Pharmaco-Optogenetic Targeting of TRPC Activity Allows for Precise Control Over Mast Cell NFAT Signaling

Frontiers in Immunology, 2020
Canonical transient receptor potential (TRPC) channels are considered as elements of the immune cell Ca2+ handling machinery. We therefore hypothesized that TRPC photopharmacology may enable uniquely specific modulation of immune responses.
Bernadett Bacsa, Annarita Graziani, Denis Krivic, Patrick Wiedner, Roland Malli, Thomas Rauter, Oleksandra Tiapko, Klaus Groschner   +7 more
doaj   +1 more source

Cold exposure and metabolic health: Therapeutic potential for obesity, diabetes, and beyond

Physiological Reports, Volume 14, Issue 7, April 2026.
Abstract Cold exposure, an inducer of brown adipose tissue thermogenesis, has been applied to relieve exercise‐induced pain and inflammation, modulate circulation and enhance metabolism. However, its role in managing metabolic diseases and the underlying molecular mechanisms remain inadequately understood.
Xirong Li, Jiale Dang, Rui Guo, Helen R. Griffiths, Shemin Lu, Dan Gao   +5 more
wiley   +1 more source

Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation.

PLoS ONE, 2011
Psoriasis is a characteristic inflammatory and scaly skin condition with typical histopathological features including increased proliferation and hampered differentiation of keratinocytes.
Kristina Leuner, Margarethe Kraus, Ute Woelfle, Heike Beschmann, Christian Harteneck, Wolf-Henning Boehncke, Christoph M Schempp, Walter E Müller   +7 more
doaj   +1 more source

Association of Immunophilins with Mammalian TRPC Channels [PDF]

Journal of Biological Chemistry, 2004
Drosophila photoreceptor channels TRP and TRPL are held in a large signalplex by the scaffolding protein, INAD. Immunophilin FKBP59, another member of the signalplex, binds to both INAD and TRPL. Mutation P702Q or P709Q in the highly conserved TRPL sequence (701)LPPPFNVLP(709), eliminates TRPL interaction with FKBP59.
William G, Sinkins, Monu, Goel, Mark, Estacion, William P, Schilling   +3 more
openaire   +2 more sources

Exploring Multifunctional Microbial Genes From the Rhizosphere of Allium ampeloprasum Under Different Fertilization Systems

Environmental DNA, Volume 8, Issue 2, March/April 2026.
This study uncovers key multifunctional genes in the rhizosphere of Allium ampeloprasum under varying fertilization systems. This highlights their roles in nutrient cycling, plant growth promotion, and soil health, thereby offering insight for sustainable agricultural sustainability.
Oluwaseun Emmanuel Shittu, Ben Jesuorsemwen Enagbonma, Olubukola Oluranti Babalola   +2 more
wiley   +1 more source