Results 81 to 90 of about 802,879 (181)

Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Pulsatile gonadotropin‐releasing hormone (GnRH) and luteinizing hormone (LH) secretion are essential for reproductive function and are thought to be governed by arcuate nucleus kisspeptin Kiss1ARH neurons via neurokinin B (NKB) signaling through TacR3.
Jian Qiu, Yanyan Lin, Emily Bartram, Janelle M. Tobias, Antonio Muñoz, Xiao Feng Li, Victoria S. Halls, James A. Frank, Martin J. Kelly, Kevin T. O'Byrne   +9 more
wiley   +1 more source

Pharmaco-Optogenetic Targeting of TRPC Activity Allows for Precise Control Over Mast Cell NFAT Signaling

Frontiers in Immunology, 2020
Canonical transient receptor potential (TRPC) channels are considered as elements of the immune cell Ca2+ handling machinery. We therefore hypothesized that TRPC photopharmacology may enable uniquely specific modulation of immune responses.
Bernadett Bacsa, Annarita Graziani, Denis Krivic, Patrick Wiedner, Roland Malli, Thomas Rauter, Oleksandra Tiapko, Klaus Groschner   +7 more
doaj   +1 more source

Staurosporine Targets Mitochondrial Regulator VdAtuA3 to Disrupt Mitochondrial Homeostasis to Control Verticillium Wilt

Plant Biotechnology Journal, Volume 24, Issue 9, Page 5131-5151, September 2026.
ABSTRACT Mitochondria serve as cellular powerhouses that generate ATP via electron transport chain complexes and orchestrate metabolism‐apoptosis cross‐talk, yet genes maintaining mitochondrial homeostasis remain underexplored as antifungal targets. In this study, a previously uncharacterised protein VdAtuA3 was identified as a novel interactor with ...
Ruo‐Cheng Sheng, Huan Li, Jun Wang, Li‐Chao Wang, Hui‐Zi Liu, Xiao‐Feng Dai, Steven J. Klosterman, Jie‐Yin Chen, Krishna V. Subbarao, Feng‐Mao Chen, Dan‐Dan Zhang   +10 more
wiley   +1 more source

Exploration of Length and Hydrophobicity Requirements for Optimal α‐Amylase Secretion in Bacillus subtilis Based on Rational Design

Microbial Biotechnology, Volume 19, Issue 8, August 2026.
Rational engineering of the B. subtilis α‐amylase signal peptide (SPAmyE) utilizing an in silico modelling approach to design a shorter, but functional SPAmyE. A synthetic SPAmyE with approximately 60% of the original length was generated and facilitated secretion of AmyE to comparable levels as the native SPAmyE.
Dicky A. Pranoto, Danilo Milo, Lorenzo de la Parra Soto, Jolanda Neef, Girbe Buist, Jan Maarten van Dijl   +5 more
wiley   +1 more source

The Vacuolar Ca2+/H+ Exchanger AaVCX Regulates Calcium Homeostasis, the Differentiation of Infection Structures and Pathogenicity in Alternaria alternata Under the Transcriptional Control of AaCrz1

Molecular Plant Pathology, Volume 27, Issue 8, August 2026.
AaVCX, a vacuolar Ca2+/H+ exchanger regulated by AaCrz1, maintains calcium homeostasis. Its deletion elevates cytoplasmic Ca2+, disrupting signals essential for spore germination, appressorium formation and infection hyphae differentiation, thereby blocking infection structure differentiation and reducing pathogenicity in Alternaria alternata ...
Yangyang Yang, Pengdong Xie, Qili Liu, Yuanping Nan, Miao Zhang, Xiaojing Wang, Yang Bi, Yongcai Li   +7 more
wiley   +1 more source

Bacillus cereus T146 Enhances Wheat Salt Tolerance by Restructuring the Rhizosphere Microbiome and Activating TaPIN1‐Dependent Auxin Transport

Plant, Cell &Environment, Volume 49, Issue 8, Page 5703-5719, August 2026.
ABSTRACT Salinity stress disrupts rhizosphere homoeostasis and inhibits root development. Although PGPR are known to alleviate such stress, critical knowledge gaps remain regarding the specific mechanisms by which they enhance tolerance under moderate to high salinity, particularly within the wheat rhizosphere ‐root interface.
Fuqiang Zhu, Taotao Wang, Zhen Wang, Yelin Shan, Panrong Ren, Xiaomin Bie, Duojia Wang, Zheng Gao, Qingjie Guan, Lei Ge, Yuan Chen   +10 more
wiley   +1 more source

TRPC Channels—Insight from the Drosophila Light Sensitive Channels

, 2018
The Drosophila Transient Receptor Potential (TRP) channel is the founding member of a large and diverse family of channel proteins. These channels are evolutionarily conserved from yeast to mammals and are found in many organisms and tissues.
Baruch Minke, William L. Pak, Ben Katz
core   +1 more source

TRPC3 and TRPC6 as molecular mediators of resistant hypertension and cardiac fibrosis: a new therapeutic frontier

Arterial Hypertension
Resistant hypertension remains a significant global health concern and is a major contributor to cardiovascular complications such as vascular dysfunction and cardiac fibrosis. Emerging evidence suggests that transient receptor potential canonical (TRPC)
Shobana Kumar, Kayatri Govindaraju, Sharifah Zamiah Syed Abdul Kadir, Abu Bakar Abdul Majeed, Amira Hajirah Abd Jamil, Nusaibah Abdul Rahim   +5 more
doaj   +1 more source

Pulmonary Hypertension Molecular Switch: HIF Signaling Pathway

Pulmonary Circulation, Volume 16, Issue 3, July 2026.
ABSTRACT Pulmonary hypertension (PH) is a multifaceted disorder characterized by the crucial involvement of activated hypoxia‐inducible factors (HIFs). Recent investigations have unveiled HIFs' ability to orchestrate a wide array of signaling cascades, encompassing voltage‐gated potassium channels, non‐selective cation channels (NSCCs), Ca2+/PKC/MAPKs,
Yinhui Sun, Rongzhen Ding, Xianli Su, Li Qin, Lihuai Wang, Jian Yi, Ruicheng Hu, Shuying You, Zhenfei Tan, Aiguo Dai   +9 more
wiley   +1 more source

TRPC channels in sensory systems [PDF]

, 2011
Transient receptor potential canonical (TRPC) channels are a family of non-selective cation channels which have a wide range of physiological functions.
Quick, K.
core