Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes [PDF]
, 2009 We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Anthony P. Albert +8 more
core +1 more source
TRPC Channels As Effectors of Cardiac Hypertrophy [PDF]
Circulation Research, 2011 Transient receptor potential (TRP) channels of multiple subclasses are expressed in the heart, although their functions are only now beginning to emerge, especially for the TRPC subclass that appears to regulate the cardiac hypertrophic response. Although TRP channels permeate many different cations, they are most often ascribed a specific
Petra, Eder, Jeffery D, Molkentin
openaire +2 more sources
Kv7 and Kv11 channels in myometrial regulation. [PDF]
, 2013 Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour.
Tribe, Rachel M; id_orcid +5 more
core +1 more source
Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes [PDF]
, 2009 In the present study the effect of phosphatidylinositol 4,5-bisphosphate (PIP2) was studied on a native TRPC1 store-operated channel (SOC) in freshly dispersed rabbit portal vein myocytes.
Saleh, Sohag N. +5 more
core +1 more source
Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer. [PDF]
PLoS ONE, 2013 The canonical transient receptor potential (TRPC) channels are Ca(2+)-permeable cationic channels controlling the Ca(2+) influx evoked by G protein-coupled receptor activation and/or by Ca(2+) store depletion. Here we investigate the involvement of TRPCs
Hong-Ni Jiang +6 more
doaj +1 more source
Physiological Function and Characterization of TRPCs in Neurons
Cells, 2014 Ca2+ entry is essential for regulating vital physiological functions in all neuronal cells. Although neurons are engaged in multiple modes of Ca2+ entry that regulates variety of neuronal functions, we will only discuss a subset of specialized Ca2 ...
Yuyang Sun +3 more
doaj +1 more source
Inhibition of native TRPC6 channel activity by phosphatidylinositol 4,5-bisphosphate in mesenteric artery myocytes [PDF]
, 2008 The present work investigates the effect of phosphatidylinositol-4,5-bisphosphate (PIP2) on native TRPC6 channel activity in freshly dispersed rabbit mesenteric artery myocytes using patch clamp recording and co-immunoprecipitation methods.
Saleh, Sohag N. +5 more
core +1 more source
TRPC Channels and their Implications for Neurological Diseases [PDF]
CNS & Neurological Disorders - Drug Targets, 2010 Calcium is an essential intracellular messenger and serves critical cellular functions in both excitable and non-excitable cells. Most of the physiological functions in these cells are uniquely regulated by changes in cytosolic Ca2+ levels ([Ca2+](i)), which are achieved via various mechanisms.
Senthil, Selvaraj +2 more
openaire +2 more sources
STAR Protocols, 2021 Summary: Small molecular probes designed for photopharmacology and opto-chemogenetics are rapidly gaining widespread recognition for investigations of transient receptor potential canonical (TRPC) channels.
Trese Leinders-Zufall +6 more
doaj +1 more source
TRPC channel activation by extracellular thioredoxin [PDF]
Nature, 2008 Mammalian homologues of Drosophila melanogaster transient receptor potential (TRP) are a large family of multimeric cation channels that act, or putatively act, as sensors of one or more chemical factor. Major research objectives are the identification of endogenous activators and the determination of cellular and tissue functions of these channels ...
Xu, Shang-Zhong +16 more
openaire +3 more sources