Results 21 to 30 of about 802,879 (181)

Ca²⁺ Influx through TRPC Channels Is Regulated by Homocysteine–Copper Complexes [PDF]

Biomolecules, 2023
An elevated level of circulating homocysteine (Hcy) has been regarded as an independent risk factor for cardiovascular disease; however, the clinical benefit of Hcy lowering-therapy is not satisfying.
Gui-Lan Chen, Bo Zeng, Hongni Jiang, Nikoleta Daskoulidou, Rahul Saurabh, Rumbidzai J. Chitando, Shang-Zhong Xu   +6 more
doaj   +2 more sources

TRPC channels as emerging targets for seizure disorders [PDF]

Trends in Pharmacological Sciences, 2022
Epilepsy is characterized by seizures of diverse types that affect about 1-2% of the population worldwide. Current antiseizure medications are unsatisfactory, as they merely provide symptomatic relief, are ineffective in about one-third of patients, and cause unbearable adverse effects. Transient receptor potential canonical (TRPC) channels are a group
Ying Yu, Wei Li, Jianxiong Jiang
openaire   +3 more sources

Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation. [PDF]

PLoS ONE, 2011
Psoriasis is a characteristic inflammatory and scaly skin condition with typical histopathological features including increased proliferation and hampered differentiation of keratinocytes.
Kristina Leuner, Margarethe Kraus, Ute Woelfle, Heike Beschmann, Christian Harteneck, Wolf-Henning Boehncke, Christoph M Schempp, Walter E Müller   +7 more
doaj   +2 more sources

TRPC channels in exercise-mimetic therapy [PDF]

Pflügers Archiv - European Journal of Physiology, 2018
Physical exercise yields beneficial effects on all types of muscle cells, which are essential for the maintenance of cardiovascular homeostasis and good blood circulation. Daily moderate exercise increases systemic antioxidative capacity, which can lead to the prevention of the onset and progression of oxidative stress-related diseases.
Takuro Numaga-Tomita, Sayaka Oda, Kazuhiro Nishiyama, Tomohiro Tanaka, Akiyuki Nishimura, Motohiro Nishida   +5 more
openaire   +3 more sources

TRPC Channels in Health and Disease

, 2017
This chapter offers a brief introduction of the functions of TRPC channels in non-neuronal systems. We focus on three major organs of which the research on TRPC channels have been most focused on: kidney, heart, and lung. The chapter highlights on cellular functions and signaling pathways mediated by TRPC channels.
Yilin, Tai, Shenglian, Yang, Yong, Liu, Wei, Shao   +3 more
openaire   +3 more sources

Structure–Function Relationship and Physiological Roles of Transient Receptor Potential Canonical (TRPC) 4 and 5 Channels

Cells, 2019
The study of the structure−function relationship of ion channels has been one of the most challenging goals in contemporary physiology. Revelation of the three-dimensional (3D) structure of ion channels has facilitated our understanding of many of ...
Jinsung Kim, Juyeon Ko, Chansik Hong, Insuk So   +3 more
doaj   +2 more sources

TRPC channels contribute to endothelial dysfunction in pulmonary arterial hypertension [PDF]

Respiratory Research
Background- Pulmonary arterial hypertension (PAH) is a rare, fatal, and progressive pulmonary vascular disease. Pulmonary endothelial cell dysfunction is a hallmark of PAH, defined by excessive proliferation and dysregulated angiogenesis, along with ...
Anaïs Saint-Martin Willer, Bastien Masson, Loann Laubry, Mary Dutheil, Kristelle El Jekmek, Gilles Carpentier, Mathieu Gourmelon, Jessica Sabourin, Marc Humbert, Olaf Mercier, Grégoire Ruffenach, David Montani, Véronique Capuano, Fabrice Antigny   +13 more
doaj   +2 more sources

Dynamics of receptor-operated Ca2+ Currents Through TRPC Channels Controlled via the PI(4,5)P2-PLC Signaling Pathway [PDF]

Frontiers in Pharmacology, 2015
Transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels that carry receptor-operated Ca2+ currents (ROCs) triggered by receptor-induced, phospholipase C (PLC)-catalyzed hydrolysis of phosphatidylinositol 4 ...
Masayuki X Mori, Kyohei eItsuki, Hideharu eHase, Seishirou eSawamura, Tatsuki eKurokawa, Yasuo eMori, Ryuji eInoue   +6 more
doaj   +2 more sources

Blockade of TRPC Channels Limits Cholinergic-Driven Hyperexcitability and Seizure Susceptibility After Traumatic Brain Injury [PDF]

Frontiers in Neuroscience, 2021
We investigated the contribution of excitatory transient receptor potential canonical (TRPC) cation channels to posttraumatic hyperexcitability in the brain 7 days following controlled cortical impact model of traumatic brain injury (TBI) to the parietal
Chase M. Carver, Haley R. DeWitt, Aiola P. Stoja, Mark S. Shapiro   +3 more
doaj   +2 more sources

TRPC channels are not required for graded persistent activity in entorhinal cortex neurons [PDF]

Hippocampus, 2019
: Adaptive behavior requires the transient storage of information beyond the physical presence of external stimuli. This short-lasting form of memory involves sustained ("persistent") neuronal firing which may be generated by cell-autonomous biophysical ...
Rebekka Medert, Lutz Birnbaumer, Medert, Rebekka, Andreas Draguhn, Alexei V. Egorov, Draguhn, Andreas, Birnbaumer, Lutz, Marc Freichel, Freichel, Marc, Egorov, Alexei V., Schumacher, Dagmar, Dagmar Schumacher   +11 more
core   +2 more sources