Results 21 to 30 of about 6,724 (162)
Role of Transient Receptor Potential Canonical Channels in Heart Physiology and Pathophysiology
Frontiers in Cardiovascular Medicine, 2020 Transient receptor potential canonical (TRPC) channels are involved in the regulation of cardiac function under (patho)physiological conditions and are closely associated with the pathogenesis of cardiac hypertrophy, arrhythmias, and myocardial ...
Hairuo Wen +3 more
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TRPC channels in exercise-mimetic therapy. [PDF]
Pflugers Arch, 2019 Physical exercise yields beneficial effects on all types of muscle cells, which are essential for the maintenance of cardiovascular homeostasis and good blood circulation. Daily moderate exercise increases systemic antioxidative capacity, which can lead to the prevention of the onset and progression of oxidative stress-related diseases.
Numaga-Tomita T +5 more
europepmc +4 more sources
Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells
Cells, 2020 Persistent neural activity has been observed in vivo during working memory tasks, and supports short-term (up to tens of seconds) retention of information.
Alberto Arboit +2 more
doaj +1 more source
Mutants in Drosophila TRPC channels reduce olfactory sensitivity to carbon dioxide. [PDF]
PLoS ONE, 2012 BACKGROUND: Members of the canonical Transient Receptor Potential (TRPC) class of cationic channels function downstream of Gαq and PLCβ in Drosophila photoreceptors for transducing visual stimuli.
Farhath Badsha +6 more
doaj +1 more source
Inhibition of diacylglycerol-sensitive TRPC channels by synthetic and natural steroids. [PDF]
PLoS ONE, 2012 TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca(2+) signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition have ...
Susanne Miehe +8 more
doaj +1 more source
Transient Receptor Potential Canonical Channels in Health and Disease: A 2020 Update
Cells, 2021 This 2020 Special Issue “TRPC channels” of Cells was dedicated to commemorating the 25th anniversary of discovery of the Transient Receptor Potential Canonical (TRPC) channel subfamily [...]
Priya R. Kirtley +3 more
doaj +1 more source
The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity
Cells, 2014 Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by ...
Fang Zheng, Kevin D. Phelan
doaj +1 more source
Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity
Journal of Lipid and Atherosclerosis, 2020 Vascular smooth muscle cells (VSMCs) play a pivotal role in the stability and tonic regulation of vascular homeostasis. VSMCs can switch back and forth between highly proliferative (synthetic) and fully differentiated (contractile) phenotypes in response
Motohiro Nishida +4 more
doaj +1 more source
mSphere, 2023 Transient receptor potential (TRP) channels are evolutionarily conserved integral membrane proteins. They serve as crucial mediators of sensory signals and have profound effects on cellular functions.
Hongchen Wang +3 more
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The integrative function of TRPC channels
Frontiers in Bioscience, 2009 TRPC is a subfamily of Transient Receptor Potential channels that have the highest degree of homology to the Drosophila photoreceptors' TRP. TRPC open in response to stimulation of plasma membrane receptors that activate phospholipase C, triggering transmembrane Ca2+ influx.
Kirill, Kiselyov, Randen L, Patterson
openaire +2 more sources