Results 11 to 20 of about 6,649 (159)
TRPC channels contribute to endothelial dysfunction in pulmonary arterial hypertension [PDF]
Respiratory ResearchBackground- Pulmonary arterial hypertension (PAH) is a rare, fatal, and progressive pulmonary vascular disease. Pulmonary endothelial cell dysfunction is a hallmark of PAH, defined by excessive proliferation and dysregulated angiogenesis, along with ...
Anaïs Saint-Martin Willer +13 more
doaj +2 more sources
TRPC channels in exercise-mimetic therapy. [PDF]
Pflugers Arch, 2019 Physical exercise yields beneficial effects on all types of muscle cells, which are essential for the maintenance of cardiovascular homeostasis and good blood circulation. Daily moderate exercise increases systemic antioxidative capacity, which can lead to the prevention of the onset and progression of oxidative stress-related diseases.
Numaga-Tomita T +5 more
europepmc +4 more sources
The mammalian TRPC cation channels
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2004 Transient Receptor Potential-Canonical (TRPC) channels are mammalian homologs of Transient Receptor Potential (TRP), a Ca(2+)-permeable channel involved in the phospholipase C-regulated photoreceptor activation mechanism in Drosophila. The seven mammalian TRPCs constitute a family of channels which have been proposed to function as store-operated as ...
Vazquez, Guillermo +4 more
openaire +4 more sources
Blockade of TRPC Channels Limits Cholinergic-Driven Hyperexcitability and Seizure Susceptibility After Traumatic Brain Injury [PDF]
Frontiers in Neuroscience, 2021 We investigated the contribution of excitatory transient receptor potential canonical (TRPC) cation channels to posttraumatic hyperexcitability in the brain 7 days following controlled cortical impact model of traumatic brain injury (TBI) to the parietal
Chase M. Carver +3 more
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TRPC channels as STIM1-regulated store-operated channels [PDF]
Cell Calcium, 2007 Receptor-activated Ca(2+) influx is mediated largely by store-operated channels (SOCs). TRPC channels mediate a significant portion of the receptor-activated Ca(2+) influx. However, whether any of the TRPC channels function as a SOC remains controversial.
Paul F, Worley +6 more
openaire +5 more sources
TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses. [PDF]
PLoS Biology, 2019 Transient receptor potential (TRP) proteins form Ca2+-permeable, nonselective cation channels, but their role in neuronal Ca2+ homeostasis is elusive. In the present paper, we show that TRPC channels potently regulate synaptic plasticity by changing the ...
Yvonne Schwarz +8 more
doaj +2 more sources
Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes [PDF]
Frontiers in Physiology, 2018 Background and Purpose: Store-operated calcium entry (SOCE) is an important physiological phenomenon that extensively mediates intracellular calcium ion (Ca2+) load. It has been previously found in myocytes isolated from neonatal or diseased hearts.
Hairuo Wen +4 more
doaj +2 more sources
Canonical Transient Receptor Potential (TRPC) Channels in Nociception and Pathological Pain [PDF]
Neural Plasticity, 2020 Chronic pathological pain is one of the most intractable clinical problems faced by clinicians and can be devastating for patients. Despite much progress we have made in understanding chronic pain in the last decades, its underlying mechanisms remain ...
Zhi-Chuan Sun +4 more
doaj +2 more sources
TRPC Channels As Effectors of Cardiac Hypertrophy [PDF]
Circulation Research, 2011 Transient receptor potential (TRP) channels of multiple subclasses are expressed in the heart, although their functions are only now beginning to emerge, especially for the TRPC subclass that appears to regulate the cardiac hypertrophic response. Although TRP channels permeate many different cations, they are most often ascribed a specific
Petra, Eder, Jeffery D, Molkentin
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TRPC channels and store-operated Ca2+ entry
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009 Store-operated calcium entry (SOCE) is a major mechanism for Ca(2+) influx. Since SOCE was first proposed two decades ago many techniques have been used in attempting to identify the nature of store-operated Ca(2+) (SOC) channels. The first identified and best-characterised store-operated current is I(CRAC), but a number of other currents activated by ...
Salido, Ginés M. +2 more
openaire +4 more sources