TRPC Channels in the SOCE Scenario [PDF]
Cells, 2020 Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in Drosophila, it is well
Jose J. Lopez +5 more
doaj +9 more sources
Angiotensin-II-Evoked Ca2+ Entry in Murine Cardiac Fibroblasts Does Not Depend on TRPC Channels [PDF]
Cells, 2020 TRPC proteins form cation conducting channels regulated by different stimuli and are regulators of the cellular calcium homeostasis. TRPC are expressed in cardiac cells including cardiac fibroblasts (CFs) and have been implicated in the development of ...
Juan E. Camacho Londoño +8 more
doaj +3 more sources
TRPC Channels in Proteinuric Kidney Diseases [PDF]
Cells, 2019 Over a decade ago, mutations in the gene encoding TRPC6 (transient receptor potential cation channel, subfamily C, member 6) were linked to development of familial forms of nephrosis. Since this discovery, TRPC6 has been implicated in the pathophysiology
Gentzon Hall +2 more
doaj +4 more sources
Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes [PDF]
Frontiers in Physiology, 2018 Background and Purpose: Store-operated calcium entry (SOCE) is an important physiological phenomenon that extensively mediates intracellular calcium ion (Ca2+) load. It has been previously found in myocytes isolated from neonatal or diseased hearts.
Hairuo Wen +4 more
doaj +3 more sources
Inhibition of diacylglycerol-sensitive TRPC channels by synthetic and natural steroids. [PDF]
PLoS ONE, 2012 TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca(2+) signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition have ...
Susanne Miehe +8 more
doaj +3 more sources
Transient receptor potential canonical (TRPC) channels in diabetes and associated complications [PDF]
ChannelsTRPC channels are widely expressed in various tissues and cell types, and accumulating evidence indicates that they play critical roles in pancreatic β cell function, including the regulation of insulin secretion.
Yi Wu, Shengming Chen, Xiaolu Xia
doaj +2 more sources
Immunohistochemistry Reveals TRPC Channels in the Human Hearing Organ—A Novel CT-Guided Approach to the Cochlea [PDF]
Int J Mol Sci, 2023 TRPC channels are critical players in cochlear hair cells and sensory neurons, as demonstrated in animal experiments. However, evidence for TRPC expression in the human cochlea is still lacking.
Martin Jung +7 more
core +2 more sources
How TRPC Channels Modulate Hippocampal Function. [PDF]
Int J Mol Sci, 2020 Transient receptor potential canonical (TRPC) proteins constitute a group of receptor-operated calcium-permeable nonselective cationic membrane channels of the TRP superfamily.
Gailly, Philippe +3 more
core +2 more sources
TRPC Channels and Parkinson’s Disease [PDF]
Adv Exp Med Biol, 2017 Parkinson's disease (PD) is a common neurodegenerative disorder, which involves degeneration of dopaminergic neurons that are present in the substantia nigra pars compacta (SNpc) region. Many factors have been identified that could lead to Parkinson's disease; however, almost all of them are directly or indirectly dependent on Ca2+ signaling ...
Pramod, Sukumaran +4 more
openaire +3 more sources
Targeting TRPC Channels for Control of Arthritis-Induced Bone Erosion [PDF]
Sci AdvArthritis leads to bone erosion due to an imbalance between osteoclast and osteoblast function. Our prior investigations revealed that the Ca2+-selective ion channel, Orai1, is critical for osteoclast maturation. Here, we show that the small-molecule ELP-
Groschner, Klaus +16 more
core +2 more sources