Results 91 to 100 of about 11,568 (219)

Cold exposure and metabolic health: Therapeutic potential for obesity, diabetes, and beyond

Physiological Reports, Volume 14, Issue 7, April 2026.
Abstract Cold exposure, an inducer of brown adipose tissue thermogenesis, has been applied to relieve exercise‐induced pain and inflammation, modulate circulation and enhance metabolism. However, its role in managing metabolic diseases and the underlying molecular mechanisms remain inadequately understood.
Xirong Li, Jiale Dang, Rui Guo, Helen R. Griffiths, Shemin Lu, Dan Gao   +5 more
wiley   +1 more source

Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta. [PDF]

PLoS ONE, 2012
Platelet-derived growth factor-CC (PDGF-CC) is the third member of the PDGF family, and has been implicated both in embryogenesis and development of the CNS.
Fuwang Peng, Honghong Yao, Halis Kaan Akturk, Shilpa Buch   +3 more
doaj   +1 more source

Association of Immunophilins with Mammalian TRPC Channels [PDF]

Journal of Biological Chemistry, 2004
Drosophila photoreceptor channels TRP and TRPL are held in a large signalplex by the scaffolding protein, INAD. Immunophilin FKBP59, another member of the signalplex, binds to both INAD and TRPL. Mutation P702Q or P709Q in the highly conserved TRPL sequence (701)LPPPFNVLP(709), eliminates TRPL interaction with FKBP59.
William G, Sinkins, Monu, Goel, Mark, Estacion, William P, Schilling   +3 more
openaire   +2 more sources

Novel Targets for Stroke Therapy: Special Focus on TRPC Channels and TRPC6

Frontiers in Aging Neuroscience, 2020
Stroke remains a leading cause of death, disability, and medical care burden worldwide. However, transformation from laboratory findings toward effective pharmacological interventions for clinical stroke has been unsatisfactory.
Lu Liu, Lijuan Gu, Manli Chen, Yueying Zheng, Xiaoxing Xiong, Xiaoxing Xiong, Shengmei Zhu   +6 more
doaj   +1 more source

Exploring Multifunctional Microbial Genes From the Rhizosphere of Allium ampeloprasum Under Different Fertilization Systems

Environmental DNA, Volume 8, Issue 2, March/April 2026.
This study uncovers key multifunctional genes in the rhizosphere of Allium ampeloprasum under varying fertilization systems. This highlights their roles in nutrient cycling, plant growth promotion, and soil health, thereby offering insight for sustainable agricultural sustainability.
Oluwaseun Emmanuel Shittu, Ben Jesuorsemwen Enagbonma, Olubukola Oluranti Babalola   +2 more
wiley   +1 more source

Heart Failure: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 3, March 2026.
This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan, Zhihua Yang, Qing Li, Meng Sun, Yumeng Pu, Ke Zhao, Yu Bao, Xianliang Wang, Jingyuan Mao, Zhiqiang Zhao   +9 more
wiley   +1 more source

Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion [PDF]

, 2004
In many cell types agonist-receptor activation leads to a rapid and transient release of Ca(2+) from intracellular stores via activation of inositol 1,4,5 trisphosphate (InsP(3)) receptors (InsP(3)Rs).
Treves, Susan, Franzini-Armstrong, Clara, Moccagatta, Luca, Arnoult, Christophe, Grasso, Cristiano, Schrum, Adam, Ducreux, Sylvie, Zhu, Michael X., Mikoshiba, Katsuhiko, Girard, Thierry, Smida-Rezgui, Sophia, Ronjat, Michel, Zorzato, Francesco   +12 more
core   +3 more sources

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

TRPC5 channels participate in pressure-sensing in aortic baroreceptors [PDF]

, 2016
published_or_final_versio
Chen, Yang-Chao, Fung, Man-Lung, Huang, Yu, Lau, On-Chai, Lo, Chun-Yin, Rudd, John Anthony, Shen, Bing, Tjong, Yung-Wui, Wang, Hui-Chuan, Wong, Ching-On, Yao, Xiaoqiang, Yung, Wing-Ho   +11 more
core   +1 more source

Nanoparticles‐Mediated Modulation of TRP Channels: Advances and Therapeutic Potential

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
Nanoparticle‐mediated modulation of TRP channels, highlighting the interplay between external stimuli, tailored nanomaterials, and TRP channel activation across a range of physiological contexts. This review examines the roles of TRP channels in cellular signaling and disease, providing insights into how advances in nanotechnology can facilitate ...
Karina A. Foster, Noy Midler, Ori Shine, Dekel Rosenfeld   +3 more
wiley   +1 more source