Results 91 to 100 of about 1,209,942 (198)

TRPC3 and TRPC6 as molecular mediators of resistant hypertension and cardiac fibrosis: a new therapeutic frontier

Arterial Hypertension
Resistant hypertension remains a significant global health concern and is a major contributor to cardiovascular complications such as vascular dysfunction and cardiac fibrosis. Emerging evidence suggests that transient receptor potential canonical (TRPC)
Shobana Kumar, Kayatri Govindaraju, Sharifah Zamiah Syed Abdul Kadir, Abu Bakar Abdul Majeed, Amira Hajirah Abd Jamil, Nusaibah Abdul Rahim   +5 more
doaj   +1 more source

TRPC channel-derived calcium fluxes differentially regulate ATP and flow-induced activation of eNOS. [PDF]

Nitric Oxide, 2021
Muzorewa TT, Buerk DG, Jaron D, Barbee KA.   +3 more
europepmc   +1 more source

Figure 1: Distribution of TRPC-6 in Dilated Atria

, 2019
(A) Immunofluorescence evaluation of transient receptor potential channel (TRPC-6) (green) in atrial tissue from mice subjected to thoracic aortic constriction (TAC) (bottom row) and in sham-operated animals (top row).
Andreas A. Werdich (4389697), Adam P. Hill (172226), Michael P. Feneley (350334), Boris Martinac (269580), Vesna Nikolova-Krstevski (6821762), Charles D. Cox (6821771), Victoria Benson (6821780), Soeren Wagner (6821765), Inken G. Huttner (6821777), Calum MacRae (6821783), Oliver Friedrich (48807), Diane Fatkin (185703), Ze Yan Yu (6821768), Jasmina Cvetkovska (6821774)   +13 more
core   +1 more source

RNA-Sequencing Analyses Demonstrate the Involvement of Canonical Transient Receptor Potential Channels in Rat Tooth Germ Development

Frontiers in Physiology, 2017
Tooth development depends on multiple molecular interactions between the dental epithelium and mesenchyme, which are derived from ectodermal and ectomesenchymal cells, respectively.
Jun Yang, Wenping Cai, Xi Lu, Shangfeng Liu, Shouliang Zhao   +4 more
doaj   +1 more source

A diacylglycerol photoswitching protocol for studying TRPC channel functions in mammalian cells and tissue slices. [PDF]

STAR Protoc, 2021
Leinders-Zufall T, Storch U, Mederos Y Schnitzler M, Ojha NK, Koike K, Gudermann T, Zufall F.   +6 more
europepmc   +1 more source

Activation of TRPC (Transient Receptor Potential Canonical) Channel Currents in Iron Overloaded Cardiac Myocytes. [PDF]

Circ Arrhythm Electrophysiol, 2021
Siri-Angkul N, Song Z, Fefelova N, Gwathmey JK, Chattipakorn SC, Qu Z, Chattipakorn N, Xie LH.   +7 more
europepmc   +1 more source

Effects of nicorandil on several gene expressions and on protein expression of TRPC channel isoforms in WT mice.

, 2012
Panel A: Quantitative analyses of ANP, BNP, β-MHC, PLB, SERCA2, NCX1, Kir6.1, Kir6.2, SUR1, SUR2A, SUR2B, eNOS, and iNOS gene expression by real-time RT-PCR in vehicle-treated WT (WT) and nicorandil-treated WT (WT+nicorandil) mouse hearts.
Fumika Sato (113755), Ayako Nishio (113741), Mitsuhiko Yamada (113758), Eiichi Taira (113753), Ulrike Mende (113749), Yasuchika Takeishi (42692), Toshihide Kashihara (113736), Naoko Matsushita (113751), Satoshi Suzuki (113746), Masamichi Hirose (113728), Tsutomu Nakada (72068), Kiyoshi Matsumoto (35129), Hisashi Shimojo (113731)   +12 more
core   +1 more source

Pharmacological characterization of the native store-operated calcium channels of cortical neuronal from embryonic mouse brain

Frontiers in Pharmacology, 2016
In the murine brain, the first post-mitotic cortical neurons formed during embryogenesis express store-operated channels (SOCs) sensitive to Pyr3, initially proposed as a blocker of transient receptor potential channel of C type 3 (TRPC3 channel ...
Sylvain Chauvet, Louis Jarvis, Mireille Chevallet, Niroj Shrestha, Klaus Groschner, Alexandre Bouron   +5 more
doaj   +1 more source

Role of phosphoinositol 4,5-bisphosphate and diacylglycerol in regulating native TRPC channel proteins in vascular smooth muscle

, 2009
Stimulation of receptor-operated (ROCs) and store-operated (SOCs) Ca2+-permeable cation channels by vasoconstrictors has many important physiological functions in vascular smooth muscle.
Saleh, Sohag N., Albert, Anthony P., Large, William A.   +2 more
core   +1 more source

TRPC channels and store-operated Ca2+ entry [PDF]

, 2009
Store-operated calcium entry (SOCE) is a major mechanism for Ca2+ influx. Since SOCE was first proposed two decades ago many techniques have been used in attempting to identify the nature of store-operated Ca2+ (SOC) channels.
Salido, Ginés M., Sage, Stewart O., Rosado, Juan A.   +2 more
core   +1 more source