Results 71 to 80 of about 1,209,942 (198)

Cytoskeletal Regulation of TRPC Channels in the Cardiorenal System [PDF]

Current Hypertension Reports, 2012
Transient receptor potential canonical (TRPC) channels have been implicated in several aspects of cardiorenal physiology including regulation of blood pressure, vasoreactivity, vascular remodeling, and glomerular filtration. Gain and loss of function studies also support the role of TRPC channels in adverse remodeling associated with cardiac ...
Jonathan A, Stiber, Youlan, Tang, TianYu, Li, Paul B, Rosenberg   +3 more
openaire   +2 more sources

Identification of canonical transient receptor potential (TRPC) channel proteins in native vascular smooth muscle cells

, 2009
Canonical transient receptor potential (TRPC) channels are Ca2+-permeable non-selective cation channels, which on stimulation allow influx of Na+ and Ca2+ ions into cells.
Saleh, Sohag N., Albert, Anthony P., Large, William A.   +2 more
core   +1 more source

BMP4 increases the expression of TRPC and basal [Ca2+]i via the p38MAPK and ERK1/2 pathways independent of BMPRII in PASMCs. [PDF]

PLoS ONE, 2014
Multiple abnormalities of bone morphogenetic protein (BMPs) signaling are implicated in the process of pulmonary arterial hypertension (PAH). BMP4 plays an important role during the process of pulmonary arterial remodeling and mutant of the principle ...
Yi Zhang, Yingfeng Wang, Kai Yang, Lichun Tian, Xin Fu, Yan Wang, Yueqian Sun, Qian Jiang, Wenju Lu, Jian Wang   +9 more
doaj   +1 more source

Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Pulsatile gonadotropin‐releasing hormone (GnRH) and luteinizing hormone (LH) secretion are essential for reproductive function and are thought to be governed by arcuate nucleus kisspeptin Kiss1ARH neurons via neurokinin B (NKB) signaling through TacR3.
Jian Qiu, Yanyan Lin, Emily Bartram, Janelle M. Tobias, Antonio Muñoz, Xiao Feng Li, Victoria S. Halls, James A. Frank, Martin J. Kelly, Kevin T. O'Byrne   +9 more
wiley   +1 more source

Characterization of Noradrenaline-Induced Increases in Intracellular Ca2+ Levels in Chinese Hamster Ovary Cells Stably Expressing Human α1A-Adrenoceptor

Journal of Pharmacological Sciences, 2007
The mechanism for noradrenaline (NA)-induced increases in intracellular Ca2+, concentration ([Ca2+]i) and physiological significance of Na+ influx through receptor-operated channels (ROCs) and store-operated channels (SOCs) were studied in Chinese ...
Takahiro Horinouchi, Yumie Miyake, Tadashi Nishiya, Arata Nishimoto, Shoko Yorozu, Atsushi Jinno, Emi Kajita, Soichi Miwa   +7 more
doaj   +1 more source

Staurosporine Targets Mitochondrial Regulator VdAtuA3 to Disrupt Mitochondrial Homeostasis to Control Verticillium Wilt

Plant Biotechnology Journal, Volume 24, Issue 9, Page 5131-5151, September 2026.
ABSTRACT Mitochondria serve as cellular powerhouses that generate ATP via electron transport chain complexes and orchestrate metabolism‐apoptosis cross‐talk, yet genes maintaining mitochondrial homeostasis remain underexplored as antifungal targets. In this study, a previously uncharacterised protein VdAtuA3 was identified as a novel interactor with ...
Ruo‐Cheng Sheng, Huan Li, Jun Wang, Li‐Chao Wang, Hui‐Zi Liu, Xiao‐Feng Dai, Steven J. Klosterman, Jie‐Yin Chen, Krishna V. Subbarao, Feng‐Mao Chen, Dan‐Dan Zhang   +10 more
wiley   +1 more source

TRPC3 Channels in Cardiac Fibrosis

Frontiers in Cardiovascular Medicine, 2017
Cardiac stiffness, caused by interstitial fibrosis due to deposition of extracellular matrix proteins, is thought as a major clinical outcome of heart failure with preserved ejection fraction (HFpEF).
Takuro Numaga-Tomita, Takuro Numaga-Tomita, Sayaka Oda, Sayaka Oda, Tsukasa Shimauchi, Tsukasa Shimauchi, Akiyuki Nishimura, Akiyuki Nishimura, Supachoke Mangmool, Motohiro Nishida, Motohiro Nishida, Motohiro Nishida, Motohiro Nishida   +12 more
doaj   +1 more source

Rat hypocretin/orexin neurons are maintained in a depolarized state by TRPC channels. [PDF]

PLoS ONE, 2010
In a previous study we proposed that the depolarized state of the wake-promoting hypocretin/orexin (hcrt/orx) neurons was independent of synaptic inputs as it persisted in tetrodotoxin and low calcium/high magnesium solutions.
Vesna Cvetkovic-Lopes, Emmanuel Eggermann, Aaron Uschakov, Jeremy Grivel, Laurence Bayer, Barbara E Jones, Mauro Serafin, Michel Mühlethaler   +7 more
doaj   +1 more source

Exploration of Length and Hydrophobicity Requirements for Optimal α‐Amylase Secretion in Bacillus subtilis Based on Rational Design

Microbial Biotechnology, Volume 19, Issue 8, August 2026.
Rational engineering of the B. subtilis α‐amylase signal peptide (SPAmyE) utilizing an in silico modelling approach to design a shorter, but functional SPAmyE. A synthetic SPAmyE with approximately 60% of the original length was generated and facilitated secretion of AmyE to comparable levels as the native SPAmyE.
Dicky A. Pranoto, Danilo Milo, Lorenzo de la Parra Soto, Jolanda Neef, Girbe Buist, Jan Maarten van Dijl   +5 more
wiley   +1 more source

Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta. [PDF]

PLoS ONE, 2012
Platelet-derived growth factor-CC (PDGF-CC) is the third member of the PDGF family, and has been implicated both in embryogenesis and development of the CNS.
Fuwang Peng, Honghong Yao, Halis Kaan Akturk, Shilpa Buch   +3 more
doaj   +1 more source