Results 31 to 40 of about 10,134 (175)

Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity

Journal of Lipid and Atherosclerosis, 2020
Vascular smooth muscle cells (VSMCs) play a pivotal role in the stability and tonic regulation of vascular homeostasis. VSMCs can switch back and forth between highly proliferative (synthetic) and fully differentiated (contractile) phenotypes in response
Motohiro Nishida, Tomohiro Tanaka, Supachoke Mangmool, Kazuhiro Nishiyama, Akiyuki Nishimura   +4 more
doaj   +1 more source

TRPC expression in human periodontal ligament cells and the periodontal tissue of periodontitis mice: a preliminary study

Laboratory Animal Research, 2023
Background Transient receptor potential canonical (TRPC) channels are non-selective cationic channels with permeability to Ca2+ and Na+. Despite their importance, there are currently few studies on TRPC in the periodontal ligament (PDL) and bone cells in
Aeryun Kim, Ae Ri Kim, Yeong-Eui Jeon, Yun‑Jung Yoo, Yu-Mi Yang, Eun‑Jung Bak   +5 more
doaj   +1 more source

The impact of tire rubber powder contaminants on the physical properties of loess

Frontiers in Environmental Science
With the development of industry and the popularization of automobiles, a large number of tires are produced globally every year, and the tire rubber powder contaminants (TRPC) generated by the friction with the ground during the driving of automobiles ...
Shaoli Liu, Qiang Sun, Qiang Sun, Qiang Sun, Pengda Ma, Rui Lv, He Zhang, Jingjing Nan, Jingjing Nan   +8 more
doaj   +1 more source

Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer. [PDF]

PLoS ONE, 2013
The canonical transient receptor potential (TRPC) channels are Ca(2+)-permeable cationic channels controlling the Ca(2+) influx evoked by G protein-coupled receptor activation and/or by Ca(2+) store depletion. Here we investigate the involvement of TRPCs
Hong-Ni Jiang, Bo Zeng, Yi Zhang, Nikoleta Daskoulidou, Hong Fan, Jie-Ming Qu, Shang-Zhong Xu   +6 more
doaj   +1 more source

TRPC channels in exercise-mimetic therapy [PDF]

Pflügers Archiv - European Journal of Physiology, 2018
Physical exercise yields beneficial effects on all types of muscle cells, which are essential for the maintenance of cardiovascular homeostasis and good blood circulation. Daily moderate exercise increases systemic antioxidative capacity, which can lead to the prevention of the onset and progression of oxidative stress-related diseases.
Takuro Numaga-Tomita, Sayaka Oda, Kazuhiro Nishiyama, Tomohiro Tanaka, Akiyuki Nishimura, Motohiro Nishida   +5 more
openaire   +2 more sources

TRPC Channels As Effectors of Cardiac Hypertrophy [PDF]

Circulation Research, 2011
Transient receptor potential (TRP) channels of multiple subclasses are expressed in the heart, although their functions are only now beginning to emerge, especially for the TRPC subclass that appears to regulate the cardiac hypertrophic response. Although TRP channels permeate many different cations, they are most often ascribed a specific
Petra, Eder, Jeffery D, Molkentin
openaire   +2 more sources

Light-Mediated Control over TRPC3-Mediated NFAT Signaling

Cells, 2020
Canonical transient receptor potential (TRPC) channels were identified as key players in maladaptive remodeling, with nuclear factor of activated T-cells (NFAT) transcription factors serving as downstream targets of TRPC-triggered Ca2+ entry in these ...
Annarita Graziani, Bernadett Bacsa, Denis Krivic, Patrick Wiedner, Sanja Curcic, Rainer Schindl, Oleksandra Tiapko, Klaus Groschner   +7 more
doaj   +1 more source

CRISPR/SaCas9 mutagenesis of stromal interaction molecule 1 in proopiomelanocortin neurons increases glutamatergic excitability and protects against diet-induced obesity

Molecular Metabolism, 2022
Objective: Proopiomelanocortin (POMC) neurons are the key anorexigenic hypothalamic neuron for integrating metabolic cues to generate the appropriate output for maintaining energy homeostasis and express the requisite channels as a perfect synaptic ...
Jian Qiu, Martha A. Bosch, Todd L. Stincic, Avery C. Hunker, Larry S. Zweifel, Oline K. Rønnekleiv, Martin J. Kelly   +6 more
doaj   +1 more source

Pulmonary Hypertension Molecular Switch: HIF Signaling Pathway. [PDF]

Pulm Circ
ABSTRACT Pulmonary hypertension (PH) is a multifaceted disorder characterized by the crucial involvement of activated hypoxia‐inducible factors (HIFs). Recent investigations have unveiled HIFs' ability to orchestrate a wide array of signaling cascades, encompassing voltage‐gated potassium channels, non‐selective cation channels (NSCCs), Ca2+/PKC/MAPKs,
Sun Y, Ding R, Su X, Qin L, Wang L, Yi J, Hu R, You S, Tan Z, Dai A.   +9 more
europepmc   +2 more sources

Ca²⁺ Influx through TRPC Channels Is Regulated by Homocysteine–Copper Complexes

Biomolecules, 2023
An elevated level of circulating homocysteine (Hcy) has been regarded as an independent risk factor for cardiovascular disease; however, the clinical benefit of Hcy lowering-therapy is not satisfying.
Gui-Lan Chen, Bo Zeng, Hongni Jiang, Nikoleta Daskoulidou, Rahul Saurabh, Rumbidzai J. Chitando, Shang-Zhong Xu   +6 more
doaj   +1 more source