Results 51 to 60 of about 10,134 (175)

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Rosiglitazone Inhibits Angiotensin II-Induced Proliferation of Glomerular Mesangial Cells via the Gαq/Plcβ4/TRPC Signaling Pathway

Cellular Physiology and Biochemistry, 2017
Background/Aims: Mesangial cell proliferation and extracellular matrix accumulation (ECM) deposition play an important role in the pathogenesis of glomerulosclerosis. TRPC and PPAR-γ can regulate cell proliferation.
Linting Wei, Jiarong Mao, Jiamei Lu, Jie Gao, Dan Zhu, Lifang Tian, Zhao Chen, Lining Jia, Li Wang, Rongguo Fu   +9 more
doaj   +1 more source

TRPC channel activation by extracellular thioredoxin [PDF]

Nature, 2008
Mammalian homologues of Drosophila melanogaster transient receptor potential (TRP) are a large family of multimeric cation channels that act, or putatively act, as sensors of one or more chemical factor. Major research objectives are the identification of endogenous activators and the determination of cellular and tissue functions of these channels ...
Xu, Shang-Zhong, Al-Shawaf, Eman, Bahnasi, Yahya M., Beech, David J., Ciurtin, Coziana, Emery, Paul, English, Anne, Jairaman, Amit, Jiang, Lin-Hua, Li, Jing, Majeed, Yasser, Milligan, Carol J., Naylor, Jacqueline, Porter, Karen E., Sivaprasadarao, Asipu, Sukumar, Piruthivi, Zeng, Fanning   +16 more
openaire   +3 more sources

Multimodal targets of (‐)‐α‐thujone mediating avoidance behavior of a stored‐products pest, Tribolium castaneum, in response to irritant stimuli

Pest Management Science, Volume 82, Issue 10, Page 9592-9598, October 2026.
We identified four kinds of target molecules against (‐)‐α‐thujone associating avoidance behavior in Tribolium castaneum, indicating multimodality. Abstract BACKGROUND The reciprocal evolutionary processes among phytophagous insects and host plants involve host shift in the herbivorous insects in response to defense chemicals, such as plant‐derived ...
Kenji Shimomura, Yuto Suzuki, Soshi Ino, Takehito Terajima, Motohiro Tomizawa   +4 more
wiley   +1 more source

Expression of Transient Receptor Potential Canonical Channel Proteins in Human Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2010
Background and objective Transient receptor potential canonical (TRPC) proteins, a group of Ca2+ permeable nonselective cation channels, are thought to constitute store-operated calcium channels (SOCC) and mediate store-operated calcium entry (SOCE) in ...
Qi ZHANG, Jianxing HE, Wenju LU, Weiqiang YIN, Haihong YANG, Xiaoming XU, Daoyuan WANG   +6 more
doaj  

Functional Aspects of TRPC Channels in Physiology and Clinical Practice: a Systematic Review

Педиатрическая фармакология
This article provides a systematic review of current research on the role of transient receptor potential calcium (TRPC) channels in various pathophysiological processes.
Razina R. Nigmatullina, Dinara I. Sadykova, Ilnara R. Sakhipgaraeva, Evgeniya S. Slastnikova, Aleksey V. Bezbryazov   +4 more
doaj   +1 more source

BRET‐Based Approaches for Ion Channels: Emerging Applications and Future Directions

Archiv der Pharmazie, Volume 359, Issue 9, September 2026.
Bioluminescence resonance energy transfer (BRET) is a versatile method for studying ligand–protein interactions. Its compatibility with high‐throughput screening and real‐time kinetics has made it widely used in drug discovery. Here, we summarize recent applications of BRET‐based methods for studying ligand binding to ion channels, highlighting key ...
Nadine Kock, Laura Heitzer, Joana Massa, Marvin Taterra, Marcel Bermúdez, Oliver Koch, Matthias Schiedel   +6 more
wiley   +1 more source

Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes

Frontiers in Physiology, 2018
Background and Purpose: Store-operated calcium entry (SOCE) is an important physiological phenomenon that extensively mediates intracellular calcium ion (Ca2+) load. It has been previously found in myocytes isolated from neonatal or diseased hearts.
Hairuo Wen, Hairuo Wen, Zhenghang Zhao, Nadezhda Fefelova, Lai-Hua Xie   +4 more
doaj   +1 more source

Urotensin II Receptor Deletion Mitigates Kidney Injury and Renal Lipid Remodeling in Mice Fed a Long‐Term High‐Fat Diet

FASEB BioAdvances, Volume 8, Issue 9, September 2026.
Urotensin II receptor deletion mitigates high‐fat diet‐induced kidney injury and renal lipid remodeling. Male wild‐type (WT) and urotensin II receptor–knockout (UT KO) mice were fed a high‐fat diet (HFD; 60% kcal from fat) for 33 weeks. In cultured mouse podocytes, urotensin II (UII)–UT signaling enhanced transient receptor potential canonical 6 (TRPC6)
Praghalathan Kanthakumar, Adebowale Adebiyi   +1 more
wiley   +1 more source

TRPC channels in smooth muscle cells [PDF]

Frontiers in Bioscience, 2010
Transient receptor potential canonical (TRPC) proteins constitute a family of seven (TRPC1-7) nonselective cation channels within the wider TRP superfamily. TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 channels are expressed in vascular smooth muscle cells from human vessels of all calibers and in smooth muscle from organs such as the uterus and the ...
Jose C, Gonzalez-Cobos, Mohamed, Trebak
openaire   +2 more sources