Results 61 to 70 of about 10,134 (175)

DHCR24 Alleviates DNA Damage in Senescent Vascular Endothelial Cells via ENKUR/Ca2+ Signaling

Aging Cell, Volume 25, Issue 9, September 2026.
In senescent vascular endothelial cells, DHCR24 deficiency triggers ENKUR‐dependent Ca2+ overload, which in turn induces endoplasmic reticulum stress and mitochondrial dysfunction, ultimately exacerbating oxidative stress and DNA damage. ABSTRACT DNA damage is considered one of the major contributors to aging.
Han Li, Zhen Yang, Wukaiyang Liang, Jie Huang, Tianyi Ji, Hao Nie, Zixin Wan, Yuqi Qiu, Yi Huang, Le Zhang, Cuntai Zhang, Jinhua Yan   +11 more
wiley   +1 more source

Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Pulsatile gonadotropin‐releasing hormone (GnRH) and luteinizing hormone (LH) secretion are essential for reproductive function and are thought to be governed by arcuate nucleus kisspeptin Kiss1ARH neurons via neurokinin B (NKB) signaling through TacR3.
Jian Qiu, Yanyan Lin, Emily Bartram, Janelle M. Tobias, Antonio Muñoz, Xiao Feng Li, Victoria S. Halls, James A. Frank, Martin J. Kelly, Kevin T. O'Byrne   +9 more
wiley   +1 more source

TRPC channels as STIM1-regulated SOCs [PDF]

Channels, 2009
Store-operated Ca(2+) channels (SOCs) are Ca(2+) influx channels at the plasma membrane whose opening is determined by the level of Ca(2+) stored in the endoplasmic reticulum lumen. SOCs are activated in response to receptor-mediated or passive depletion of ER Ca(2+) to regulate many Ca(2+)-dependent cellular functions.
Joseph P, Yuan, Min Seuk, Kim, Weizhong, Zeng, Dong Min, Shin, Guo, Huang, Paul F, Worley, Shmuel, Muallem   +6 more
openaire   +2 more sources

Ultra-wideband transmitter design based on a new transmitted reference pulse cluster

ICT Express, 2017
This study presents an energy efficient ultra-wideband (UWB) transmitter based on the novel transmitted reference pulse cluster (TRPC) modulation scheme.
Yiming Huo, Xiaodai Dong, Ping Lu
doaj   +1 more source

How filopodia respond to calcium in the absence of a calcium-binding structural protein: non-channel functions of TRP

Cell Communication and Signaling, 2022
Background For many cell types, directional locomotion depends on their maintaining filopodia at the leading edge. Filopodia lack any Ca2+-binding structural protein but respond to store-operated Ca2+ entry (SOCE).
C. A. Heckman, O. M. Ademuyiwa, M. L. Cayer   +2 more
doaj   +1 more source

Staurosporine Targets Mitochondrial Regulator VdAtuA3 to Disrupt Mitochondrial Homeostasis to Control Verticillium Wilt

Plant Biotechnology Journal, Volume 24, Issue 9, Page 5131-5151, September 2026.
ABSTRACT Mitochondria serve as cellular powerhouses that generate ATP via electron transport chain complexes and orchestrate metabolism‐apoptosis cross‐talk, yet genes maintaining mitochondrial homeostasis remain underexplored as antifungal targets. In this study, a previously uncharacterised protein VdAtuA3 was identified as a novel interactor with ...
Ruo‐Cheng Sheng, Huan Li, Jun Wang, Li‐Chao Wang, Hui‐Zi Liu, Xiao‐Feng Dai, Steven J. Klosterman, Jie‐Yin Chen, Krishna V. Subbarao, Feng‐Mao Chen, Dan‐Dan Zhang   +10 more
wiley   +1 more source

Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation.

PLoS ONE, 2011
Psoriasis is a characteristic inflammatory and scaly skin condition with typical histopathological features including increased proliferation and hampered differentiation of keratinocytes.
Kristina Leuner, Margarethe Kraus, Ute Woelfle, Heike Beschmann, Christian Harteneck, Wolf-Henning Boehncke, Christoph M Schempp, Walter E Müller   +7 more
doaj   +1 more source

Exploration of Length and Hydrophobicity Requirements for Optimal α‐Amylase Secretion in Bacillus subtilis Based on Rational Design

Microbial Biotechnology, Volume 19, Issue 8, August 2026.
Rational engineering of the B. subtilis α‐amylase signal peptide (SPAmyE) utilizing an in silico modelling approach to design a shorter, but functional SPAmyE. A synthetic SPAmyE with approximately 60% of the original length was generated and facilitated secretion of AmyE to comparable levels as the native SPAmyE.
Dicky A. Pranoto, Danilo Milo, Lorenzo de la Parra Soto, Jolanda Neef, Girbe Buist, Jan Maarten van Dijl   +5 more
wiley   +1 more source

Association of Immunophilins with Mammalian TRPC Channels [PDF]

Journal of Biological Chemistry, 2004
Drosophila photoreceptor channels TRP and TRPL are held in a large signalplex by the scaffolding protein, INAD. Immunophilin FKBP59, another member of the signalplex, binds to both INAD and TRPL. Mutation P702Q or P709Q in the highly conserved TRPL sequence (701)LPPPFNVLP(709), eliminates TRPL interaction with FKBP59.
William G, Sinkins, Monu, Goel, Mark, Estacion, William P, Schilling   +3 more
openaire   +2 more sources

The Vacuolar Ca2+/H+ Exchanger AaVCX Regulates Calcium Homeostasis, the Differentiation of Infection Structures and Pathogenicity in Alternaria alternata Under the Transcriptional Control of AaCrz1

Molecular Plant Pathology, Volume 27, Issue 8, August 2026.
AaVCX, a vacuolar Ca2+/H+ exchanger regulated by AaCrz1, maintains calcium homeostasis. Its deletion elevates cytoplasmic Ca2+, disrupting signals essential for spore germination, appressorium formation and infection hyphae differentiation, thereby blocking infection structure differentiation and reducing pathogenicity in Alternaria alternata ...
Yangyang Yang, Pengdong Xie, Qili Liu, Yuanping Nan, Miao Zhang, Xiaojing Wang, Yang Bi, Yongcai Li   +7 more
wiley   +1 more source