Results 61 to 70 of about 9,940 (176)

Magnetic Reprogramming of Macrophages Stimulates Phagocytosis of Breast Cancer Cells via a TRPC1‐STING Inflammatory Axis

Smart Medicine, Volume 5, Issue 3, June 2026.
Magnetic fields modulate macrophage‐cancer crosstalk through the STING‐TRPC1 axis. Exposure reprograms macrophages toward the anti‐cancer phenotype. Exposing cancer cells modulates cancer secretome to promote polarization and selective recruitment of M1‐tumoricidal macrophages, enhancing cancer immunogenicity.
Viresh Krishnan Sukumar, Yee Kit Tai, Jan Nikolas Iversen, Olivia Yeo, Anisha Praiselin Paul, Kwan Yu Wu, Lina Hsiu Kim Lim, Alfredo Franco‐Obregón   +7 more
wiley   +1 more source

TRPC expression in mesenchymal stem cells [PDF]

Cellular and Molecular Biology Letters, 2010
AbstractTransient receptor potential canonical (TRPC) channels are key players in calcium homeostasis and various regulatory processes in cell biology. Little is currently known about the TRPC subfamily members in mesenchymal stem cells (MSC), where they could play a role in cell proliferation.
Torossian, Frederic, Bisson, Aurelie, Vannier, Jean-Pierre, Boyer, Olivier, Lamacz, Marek   +4 more
openaire   +2 more sources

Ultra-wideband transmitter design based on a new transmitted reference pulse cluster

ICT Express, 2017
This study presents an energy efficient ultra-wideband (UWB) transmitter based on the novel transmitted reference pulse cluster (TRPC) modulation scheme.
Yiming Huo, Xiaodai Dong, Ping Lu
doaj   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, Volume 183, Issue 9, Page 2139-2165, May 2026.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

TRPC Channels and their Implications for Neurological Diseases [PDF]

CNS & Neurological Disorders - Drug Targets, 2010
Calcium is an essential intracellular messenger and serves critical cellular functions in both excitable and non-excitable cells. Most of the physiological functions in these cells are uniquely regulated by changes in cytosolic Ca2+ levels ([Ca2+](i)), which are achieved via various mechanisms.
Senthil, Selvaraj, Yuyang, Sun, Brij B, Singh   +2 more
openaire   +2 more sources

Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation.

PLoS ONE, 2011
Psoriasis is a characteristic inflammatory and scaly skin condition with typical histopathological features including increased proliferation and hampered differentiation of keratinocytes.
Kristina Leuner, Margarethe Kraus, Ute Woelfle, Heike Beschmann, Christian Harteneck, Wolf-Henning Boehncke, Christoph M Schempp, Walter E Müller   +7 more
doaj   +1 more source

Pacemaking in the heart: a redundant and robust system of mutually entrained oscillators driving cardiac automaticity

The Journal of Physiology, Volume 604, Issue 9, Page 3504-3512, 1 May 2026.
Abstract figure legend Cardiac pacemaking: the redundant and robust organ‐to‐subcellular system driving the spontaneous electrical activity responsible for regular, rhythmic excitation of the heart. Abstract The heart is an electrically controlled, mechanical pump that provides a constant supply of blood to the body.
Eilidh A. MacDonald, T. Alexander Quinn
wiley   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, Volume 15, Issue 13, 3 April 2026.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source

Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy

Cancer Cell International, 2009
Background Ca2+ is known to be involved in a number of metastatic processes including motility and proliferation which can result in store-depletion of Ca2+.
Djamgoz Mustafa, Yeo Syn, Aydar Ebru, Palmer Christopher   +3 more
doaj   +1 more source

Neuroplasticity‐Driven Mechanisms and Therapeutic Targets in the Anterior Cingulate Cortex in Neuropathic Pain

Brain and Behavior, Volume 16, Issue 4, April 2026.
The anterior cingulate cortex (ACC), as the center for pain and emotion integration, causes integration disorders due to excessive synaptic strengthening and glial cell inflammation/synaptic pruning dysregulation. However, traditional drugs have insufficient targeting, and closed‐loop DBS improves symptoms by precisely regulating ACC.
Haibing Xiong, Letai Li, Yanlin Li, Yutong Chen, Jiajie Leng, Tingting Chen   +5 more
wiley   +1 more source