Results 21 to 30 of about 10,134 (175)
Mutants in Drosophila TRPC channels reduce olfactory sensitivity to carbon dioxide. [PDF]
PLoS ONE, 2012 BACKGROUND: Members of the canonical Transient Receptor Potential (TRPC) class of cationic channels function downstream of Gαq and PLCβ in Drosophila photoreceptors for transducing visual stimuli.
Farhath Badsha +6 more
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Frontiers in Immunology, 2020 Canonical transient receptor potential (TRPC) channels are considered as elements of the immune cell Ca2+ handling machinery. We therefore hypothesized that TRPC photopharmacology may enable uniquely specific modulation of immune responses.
Bernadett Bacsa +7 more
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Angiotensin-II-Evoked Ca2+ Entry in Murine Cardiac Fibroblasts Does Not Depend on TRPC Channels
Cells, 2020 TRPC proteins form cation conducting channels regulated by different stimuli and are regulators of the cellular calcium homeostasis. TRPC are expressed in cardiac cells including cardiac fibroblasts (CFs) and have been implicated in the development of ...
Juan E. Camacho Londoño +8 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundTransient receptor potential channels (TRPC) play critical regulatory functions in cancer occurrence and progression. However, knowledge on its role in colorectal cancer (CRC) is limited. In addition, neoadjuvant treatment and immune checkpoint
Lei Wang +7 more
doaj +1 more source
TRPC Channels and Parkinson’s Disease [PDF]
, 2017 Parkinson's disease (PD) is a common neurodegenerative disorder, which involves degeneration of dopaminergic neurons that are present in the substantia nigra pars compacta (SNpc) region. Many factors have been identified that could lead to Parkinson's disease; however, almost all of them are directly or indirectly dependent on Ca2+ signaling ...
Pramod, Sukumaran +4 more
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The integrative function of TRPC channels
Frontiers in Bioscience, 2009 TRPC is a subfamily of Transient Receptor Potential channels that have the highest degree of homology to the Drosophila photoreceptors' TRP. TRPC open in response to stimulation of plasma membrane receptors that activate phospholipase C, triggering transmembrane Ca2+ influx.
Kirill, Kiselyov, Randen L, Patterson
openaire +2 more sources
The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity
Cells, 2014 Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by ...
Fang Zheng, Kevin D. Phelan
doaj +1 more source
TRPCs: Influential Mediators in Skeletal Muscle [PDF]
Cells, 2020 Ca2+ itself or Ca2+-dependent signaling pathways play fundamental roles in various cellular processes from cell growth to death. The most representative example can be found in skeletal muscle cells where a well-timed and adequate supply of Ca2+ is required for coordinated Ca2+-dependent skeletal muscle functions, such as the interactions of ...
Choi, JH +4 more
openaire +5 more sources
European Pharmaceutical Journal, 2018 Aim: The aim is to identify the possible changes in the expression of genes, that regulate calcium homeostasis in cardiomyocytes in diabetes mellitus.
Dragún M. +4 more
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Frontiers in Pharmacology, 2015 Transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels that carry receptor-operated Ca2+ currents (ROCs) triggered by receptor-induced, phospholipase C (PLC)-catalyzed hydrolysis of phosphatidylinositol 4 ...
Masayuki X Mori +6 more
doaj +1 more source