Results 11 to 20 of about 10,134 (175)
Physiological Function and Characterization of TRPCs in Neurons
Cells, 2014 Ca2+ entry is essential for regulating vital physiological functions in all neuronal cells. Although neurons are engaged in multiple modes of Ca2+ entry that regulates variety of neuronal functions, we will only discuss a subset of specialized Ca2 ...
Yuyang Sun +3 more
doaj +3 more sources
TRPC Channels in the SOCE Scenario
Cells, 2020 Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in Drosophila, it is well
Jose J. Lopez +5 more
doaj +7 more sources
TRPC3-Driven Calcium Microdomains Instruct Peripheral Nerve Regeneration With Protective Implications for Central Neurons. [PDF]
Adv Sci (Weinh)How localized Ca2+ signals orchestrate neural repair remains unclear. Here, we show that TRPC3‐driven calcium microdomains direct nerve repair by coupling spatially confined Ca2+ signals to axon regeneration. This module operates in injured peripheral neurons and correlates with neuroprotection in Parkinson's disease, revealing a spatial logic for ...
Lu Y +14 more
europepmc +2 more sources
Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin. [PDF]
J PhysiolAbstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Alemayhu AM, Paulsen CE.
europepmc +2 more sources
TRPC Channels: Dysregulation and Ca2+ Mishandling in Ischemic Heart Disease
Cells, 2020 Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac cells where they sense and respond to a wide variety of physical and chemical stimuli.
Débora Falcón +7 more
doaj +1 more source
Inhibition of diacylglycerol-sensitive TRPC channels by synthetic and natural steroids. [PDF]
PLoS ONE, 2012 TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca(2+) signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition have ...
Susanne Miehe +8 more
doaj +1 more source
TRPCs, GPCRs and the Bayliss effect [PDF]
The EMBO Journal, 2009 An increase in pressure inside most small arteries unexpectedly results in a vasoconstriction. This phenomenon, known as the Bayliss effect, involves the stretch‐induced activation of non‐selective cation channels in the vascular smooth muscle cells. Recent work by Mederos y Schnitzler et al . now demonstrates that the stretch‐induced channel activity
Voets, Thomas, Nilius, Bernd
openaire +3 more sources
Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells
Cells, 2020 Persistent neural activity has been observed in vivo during working memory tasks, and supports short-term (up to tens of seconds) retention of information.
Alberto Arboit +2 more
doaj +1 more source
TRPC1/5-CaV3 Complex Mediates Leptin-Induced Excitability in Hypothalamic Neurons
Frontiers in Neuroscience, 2021 Leptin regulates hypothalamic POMC+ (pro-opiomelanocortin) neurons by inducing TRPC (Transient Receptor Potential Cation) channel-mediate membrane depolarization.
Paula P. Perissinotti +2 more
doaj +1 more source
Cells, 2019 The study of the structure−function relationship of ion channels has been one of the most challenging goals in contemporary physiology. Revelation of the three-dimensional (3D) structure of ion channels has facilitated our understanding of many of ...
Jinsung Kim +3 more
doaj +1 more source