Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy [PDF]
, 2009 Background Ca2+ is known to be involved in a number of metastatic processes including motility and proliferation which can result in store-depletion of Ca2+.
Christopher Palmer +3 more
core +2 more sources
TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice [PDF]
, 2017 Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive ...
Birnbaumer, Lutz +10 more
core +1 more source
TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses.
PLoS Biology, 2019 Transient receptor potential (TRP) proteins form Ca2+-permeable, nonselective cation channels, but their role in neuronal Ca2+ homeostasis is elusive. In the present paper, we show that TRPC channels potently regulate synaptic plasticity by changing the ...
Yvonne Schwarz +8 more
doaj +1 more source
Critical role of canonical transient receptor potential channel 7 in initiation of seizures [PDF]
, 2014 Status epilepticus (SE) is a life-threatening disease that has been recognized since antiquity but still causes over 50,000 deaths annually in the United States.
Abramowitz, J. +4 more
core +1 more source
Post-Translational Modification and Natural Mutation of TRPC Channels
Cells, 2020 Transient Receptor Potential Canonical (TRPC) channels are homologues of Drosophila TRP channel first cloned in mammalian cells. TRPC family consists of seven members which are nonselective cation channels with a high Ca2+ permeability and are activated ...
Xianji Liu +2 more
doaj +1 more source
TRP channels: Role in neurodegenerative diseases and therapeutic targets
Heliyon, 2023 TRP (Transient receptor potential) channels are integral membrane proteins consisting of a superfamily of cation channels that allow permeability of both monovalent and divalent cations. TRP channels are subdivided into six subfamilies: TRPC, TRPV, TRPM,
Mashoque Ahmad Rather +6 more
doaj +1 more source
Erythropoietin Increases Expression and Function of Transient Receptor Potential Canonical 5 Channels [PDF]
, 2011 Hypertension is a common complication in hemodialysis patients during erythropoietin (EPO) treatment. The underlying mechanisms of EPO-induced hypertension still remain to be determined. Increased transient receptor potential canonical (TRPC)
Friis, Ulla G +7 more
core +1 more source
Novel Targets for Stroke Therapy: Special Focus on TRPC Channels and TRPC6
Frontiers in Aging Neuroscience, 2020 Stroke remains a leading cause of death, disability, and medical care burden worldwide. However, transformation from laboratory findings toward effective pharmacological interventions for clinical stroke has been unsatisfactory.
Lu Liu +6 more
doaj +1 more source
Store-operated interactions between plasmalemmal STIM1 and TRPC1 proteins stimulate PLCβ1 to induce TRPC1 channel activation in vascular smooth muscle cells. [PDF]
, 2016 KEY POINTS: Depletion of Ca(2+) stores activates store-operated channels (SOCs), which mediate Ca(2+) entry pathways that regulate cellular processes such as contraction, proliferation and gene expression.
Albert, AP +4 more
core +2 more sources
Characterization of the S100A1 protein binding site on TRPC6 C-terminus. [PDF]
PLoS ONE, 2013 The transient receptor potential (TRP) protein superfamily consists of seven major groups, among them the "canonical TRP" family. The TRPC proteins are calcium-permeable nonselective cation channels activated after the emptying of intracellular calcium ...
Jan Bily +6 more
doaj +1 more source