Results 41 to 50 of about 4,772 (153)
Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
F1000Research, 2013 The canonical transient receptor potential (TRPC) family of Ca2+ permeable, non-selective cation channels is abundantly expressed throughout the brain, and plays a pivotal role in modulating cellular excitability.
Kristin C Rasmus +3 more
doaj +1 more source
Frontiers in Immunology, 2020 Mast cells are a heterogeneous group of immune cells. The simplest and commonly accepted classification divides them in two groups according to their protease content. We have compared the action of diverse secretagogues on bone marrow derived (BMMC) and
Volodymyr Tsvilovskyy +7 more
doaj +1 more source
Oncogenesis, 2021 Transient receptor potential canonical (TRPC) channels are the most prominent nonselective cation channels involved in various diseases. However, the function, clinical significance, and molecular mechanism of TRPCs in colorectal cancer (CRC) progression
Yang Sun +10 more
doaj +1 more source
Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders
Oral Diseases, EarlyView.ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz +6 more
wiley +1 more source
Molecular Metabolism, 2018 Objective: Diabetic retinopathy (DR) is induced by an accumulation of reactive metabolites such as ROS, RNS, and RCS species, which were reported to modulate the activity of cation channels of the TRPC family.
Robin Sachdeva +13 more
doaj +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Mitochondria serve as cellular powerhouses that generate ATP via electron transport chain complexes and orchestrate metabolism‐apoptosis cross‐talk, yet genes maintaining mitochondrial homeostasis remain underexplored as antifungal targets. In this study, a previously uncharacterised protein VdAtuA3 was identified as a novel interactor with ...
Ruo‐Cheng Sheng +10 more
wiley +1 more source
Journal of Pharmacological Sciences, 2007 The mechanism for noradrenaline (NA)-induced increases in intracellular Ca2+, concentration ([Ca2+]i) and physiological significance of Na+ influx through receptor-operated channels (ROCs) and store-operated channels (SOCs) were studied in Chinese ...
Takahiro Horinouchi +7 more
doaj +1 more source
A sensory-motor neuron type mediates proprioceptive coordination of steering in C. elegans via two TRPC channels. [PDF]
PLoS Biology, 2018 Animal locomotion is mediated by a sensory system referred to as proprioception. Defects in the proprioceptive coordination of locomotion result in uncontrolled and inefficient movements.
Jihye Yeon +9 more
doaj +1 more source
Photochemistry of CryB from Rhodobacter sphaeroides
Photochemistry and Photobiology, EarlyView.Elucidation of the photochemistry of CryB from Rhodobacter sphaeroides was achieved from the nanosecond to second timescale. A fast (<5 ns) deprotonation of the terminal electron donor Trp338 and the involvement of Tyr337 in photoreduction have been revealed.
Christopher Einholz +6 more
wiley +1 more source