Results 41 to 50 of about 1,006,736 (177)
Frontiers in Neuroscience, 2021 We investigated the contribution of excitatory transient receptor potential canonical (TRPC) cation channels to posttraumatic hyperexcitability in the brain 7 days following controlled cortical impact model of traumatic brain injury (TBI) to the parietal
Chase M. Carver +3 more
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TRPC Channels: Dysregulation and Ca2+ Mishandling in Ischemic Heart Disease [PDF]
, 2020 Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac cells where they sense and respond to a wide variety of physical and chemical stimuli.
Martín Bórnez, Marta +21 more
core +1 more source
Canonical Transient Receptor Potential (TRPC) Channels in Nociception and Pathological Pain
Neural Plasticity, 2020 Chronic pathological pain is one of the most intractable clinical problems faced by clinicians and can be devastating for patients. Despite much progress we have made in understanding chronic pain in the last decades, its underlying mechanisms remain ...
Zhi-Chuan Sun +4 more
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Kv7 and Kv11 channels in myometrial regulation. [PDF]
, 2013 Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour.
Tribe, Rachel M; id_orcid +5 more
core +1 more source
Novel Targets for Stroke Therapy: Special Focus on TRPC Channels and TRPC6
Frontiers in Aging Neuroscience, 2020 Stroke remains a leading cause of death, disability, and medical care burden worldwide. However, transformation from laboratory findings toward effective pharmacological interventions for clinical stroke has been unsatisfactory.
Lu Liu +6 more
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TRP channels: Role in neurodegenerative diseases and therapeutic targets
Heliyon, 2023 TRP (Transient receptor potential) channels are integral membrane proteins consisting of a superfamily of cation channels that allow permeability of both monovalent and divalent cations. TRP channels are subdivided into six subfamilies: TRPC, TRPV, TRPM,
Mashoque Ahmad Rather +6 more
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Characterization of the S100A1 protein binding site on TRPC6 C-terminus. [PDF]
PLoS ONE, 2013 The transient receptor potential (TRP) protein superfamily consists of seven major groups, among them the "canonical TRP" family. The TRPC proteins are calcium-permeable nonselective cation channels activated after the emptying of intracellular calcium ...
Jan Bily +6 more
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Electron cryo-microscopy structure of the canonical TRPC4 ion channel
eLife, 2018 Canonical transient receptor channels (TRPC) are non-selective cation channels. They are involved in receptor-operated Ca2+ signaling and have been proposed to act as store-operated channels (SOC).
Deivanayagabarathy Vinayagam +7 more
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Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
Cells, 2018 Proteins of the TRPC family can form many homo- and heterotetrameric cation channels permeable to Na+, K+ and Ca2+. In this review, we focus on channels formed by the isoforms TRPC1, TRPC4 and TRPC5.
Aisling Minard +6 more
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