Results 61 to 70 of about 1,006,736 (177)

TRPC channels are not required for graded persistent activity in entorhinal cortex neurons [PDF]

, 2019
: Adaptive behavior requires the transient storage of information beyond the physical presence of external stimuli. This short-lasting form of memory involves sustained ("persistent") neuronal firing which may be generated by cell-autonomous biophysical ...
Rebekka Medert, Lutz Birnbaumer, Medert, Rebekka, Andreas Draguhn, Alexei V. Egorov, Draguhn, Andreas, Birnbaumer, Lutz, Marc Freichel, Freichel, Marc, Egorov, Alexei V., Schumacher, Dagmar, Dagmar Schumacher   +11 more
core   +1 more source

BRET‐Based Approaches for Ion Channels: Emerging Applications and Future Directions

Archiv der Pharmazie, Volume 359, Issue 9, September 2026.
Bioluminescence resonance energy transfer (BRET) is a versatile method for studying ligand–protein interactions. Its compatibility with high‐throughput screening and real‐time kinetics has made it widely used in drug discovery. Here, we summarize recent applications of BRET‐based methods for studying ligand binding to ion channels, highlighting key ...
Nadine Kock, Laura Heitzer, Joana Massa, Marvin Taterra, Marcel Bermúdez, Oliver Koch, Matthias Schiedel   +6 more
wiley   +1 more source

A sensory-motor neuron type mediates proprioceptive coordination of steering in C. elegans via two TRPC channels. [PDF]

PLoS Biology, 2018
Animal locomotion is mediated by a sensory system referred to as proprioception. Defects in the proprioceptive coordination of locomotion result in uncontrolled and inefficient movements.
Jihye Yeon, Jinmahn Kim, Do-Young Kim, Hyunmin Kim, Jungha Kim, Eun Jo Du, KyeongJin Kang, Hyun-Ho Lim, Daewon Moon, Kyuhyung Kim   +9 more
doaj   +1 more source

TRPC Channels in Health and Disease

, 2017
This chapter offers a brief introduction of the functions of TRPC channels in non-neuronal systems. We focus on three major organs of which the research on TRPC channels have been most focused on: kidney, heart, and lung.
Liu, Y., Tai, Y., Wei Shao, Shao, W., Yong Liu, Yilin Tai, Shenglian Yang, Yang, S.   +7 more
core   +1 more source

TRPC3 and TRPC6 as molecular mediators of resistant hypertension and cardiac fibrosis: a new therapeutic frontier

Arterial Hypertension
Resistant hypertension remains a significant global health concern and is a major contributor to cardiovascular complications such as vascular dysfunction and cardiac fibrosis. Emerging evidence suggests that transient receptor potential canonical (TRPC)
Shobana Kumar, Kayatri Govindaraju, Sharifah Zamiah Syed Abdul Kadir, Abu Bakar Abdul Majeed, Amira Hajirah Abd Jamil, Nusaibah Abdul Rahim   +5 more
doaj   +1 more source

DHCR24 Alleviates DNA Damage in Senescent Vascular Endothelial Cells via ENKUR/Ca2+ Signaling

Aging Cell, Volume 25, Issue 9, September 2026.
In senescent vascular endothelial cells, DHCR24 deficiency triggers ENKUR‐dependent Ca2+ overload, which in turn induces endoplasmic reticulum stress and mitochondrial dysfunction, ultimately exacerbating oxidative stress and DNA damage. ABSTRACT DNA damage is considered one of the major contributors to aging.
Han Li, Zhen Yang, Wukaiyang Liang, Jie Huang, Tianyi Ji, Hao Nie, Zixin Wan, Yuqi Qiu, Yi Huang, Le Zhang, Cuntai Zhang, Jinhua Yan   +11 more
wiley   +1 more source

Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Pulsatile gonadotropin‐releasing hormone (GnRH) and luteinizing hormone (LH) secretion are essential for reproductive function and are thought to be governed by arcuate nucleus kisspeptin Kiss1ARH neurons via neurokinin B (NKB) signaling through TacR3.
Jian Qiu, Yanyan Lin, Emily Bartram, Janelle M. Tobias, Antonio Muñoz, Xiao Feng Li, Victoria S. Halls, James A. Frank, Martin J. Kelly, Kevin T. O'Byrne   +9 more
wiley   +1 more source

Vascular Dysfunction in Diabetes and Obesity: Focus on TRP Channels

Frontiers in Physiology, 2021
Transient receptor potential (TRP) superfamily consists of a diverse group of non-selective cation channels that has a wide tissue distribution and is involved in many physiological processes including sensory perception, secretion of hormones ...
Raiana dos Anjos Moraes, Raiana dos Anjos Moraes, R. Clinton Webb, Darízy Flávia Silva, Darízy Flávia Silva   +4 more
doaj   +1 more source

Staurosporine Targets Mitochondrial Regulator VdAtuA3 to Disrupt Mitochondrial Homeostasis to Control Verticillium Wilt

Plant Biotechnology Journal, Volume 24, Issue 9, Page 5131-5151, September 2026.
ABSTRACT Mitochondria serve as cellular powerhouses that generate ATP via electron transport chain complexes and orchestrate metabolism‐apoptosis cross‐talk, yet genes maintaining mitochondrial homeostasis remain underexplored as antifungal targets. In this study, a previously uncharacterised protein VdAtuA3 was identified as a novel interactor with ...
Ruo‐Cheng Sheng, Huan Li, Jun Wang, Li‐Chao Wang, Hui‐Zi Liu, Xiao‐Feng Dai, Steven J. Klosterman, Jie‐Yin Chen, Krishna V. Subbarao, Feng‐Mao Chen, Dan‐Dan Zhang   +10 more
wiley   +1 more source

TRPC1 Channels Are Expressed in Pyramidal Neurons and in a Subset of Somatostatin Interneurons in the Rat Neocortex

Frontiers in Neuroanatomy, 2018
Disturbances in calcium homeostasis due to canonical transient receptor potential (TRPC) and/or store-operated calcium (SOC) channels can play a key role in a large number of brain disorders.
Juan R. Martinez-Galan, Ana Verdejo, Elena Caminos   +2 more
doaj   +1 more source