Results 61 to 70 of about 4,772 (153)

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, Volume 15, Issue 13, 3 April 2026.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source

In the gravid human uterus, oxytocin induces smooth muscle cell contraction via transient receptor potential vanilloid 4 channel activation

The Journal of Physiology, Volume 604, Issue 7, Page 3135-3158, 1 April 2026.
Abstract figure legend In gravid human uterus smooth muscle, the oxytocin receptor (OXTR) and transient receptor potential vanilloid 4 (TRPV4) calcium channel colocalize at <40 nm by proximity ligation. TRPV4 is necessary for oxytocin‐induced calcium influx and contractility in uterine smooth muscle cells.
Daiana Fornes, Jessica R. Ansari, Guillermina Michel, Cristina M. Alvira, David N. Cornfield   +4 more
wiley   +1 more source

Cold exposure and metabolic health: Therapeutic potential for obesity, diabetes, and beyond

Physiological Reports, Volume 14, Issue 7, April 2026.
Abstract Cold exposure, an inducer of brown adipose tissue thermogenesis, has been applied to relieve exercise‐induced pain and inflammation, modulate circulation and enhance metabolism. However, its role in managing metabolic diseases and the underlying molecular mechanisms remain inadequately understood.
Xirong Li, Jiale Dang, Rui Guo, Helen R. Griffiths, Shemin Lu, Dan Gao   +5 more
wiley   +1 more source

TRPC3 Channels in Cardiac Fibrosis

Frontiers in Cardiovascular Medicine, 2017
Cardiac stiffness, caused by interstitial fibrosis due to deposition of extracellular matrix proteins, is thought as a major clinical outcome of heart failure with preserved ejection fraction (HFpEF).
Takuro Numaga-Tomita, Takuro Numaga-Tomita, Sayaka Oda, Sayaka Oda, Tsukasa Shimauchi, Tsukasa Shimauchi, Akiyuki Nishimura, Akiyuki Nishimura, Supachoke Mangmool, Motohiro Nishida, Motohiro Nishida, Motohiro Nishida, Motohiro Nishida   +12 more
doaj   +1 more source

TRP Channels in Angiogenesis and Other Endothelial Functions

Frontiers in Physiology, 2018
Angiogenesis is the growth of blood vessels mediated by proliferation, migration, and spatial organization of endothelial cells. This mechanism is regulated by a balance between stimulatory and inhibitory factors.
Tarik Smani, Tarik Smani, Luis J. Gómez, Sergio Regodon, Geoffrey E. Woodard, Geraldine Siegfried, Abdel-Majid Khatib, Juan A. Rosado   +7 more
doaj   +1 more source

TRP Channels Role in Pain Associated With Neurodegenerative Diseases

Frontiers in Neuroscience, 2020
Transient receptor potential (TRP) are cation channels expressed in both non-excitable and excitable cells from diverse tissues, including heart, lung, and brain.
Milena Duitama, Viviana Vargas-López, Zulma Casas, Sonia L. Albarracin, Jhon-Jairo Sutachan, Yolima P. Torres   +5 more
doaj   +1 more source

Heart Failure: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 3, March 2026.
This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan, Zhihua Yang, Qing Li, Meng Sun, Yumeng Pu, Ke Zhao, Yu Bao, Xianliang Wang, Jingyuan Mao, Zhiqiang Zhao   +9 more
wiley   +1 more source

Expression of Transient Receptor Potential Canonical Channel Proteins in Human Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2010
Background and objective Transient receptor potential canonical (TRPC) proteins, a group of Ca2+ permeable nonselective cation channels, are thought to constitute store-operated calcium channels (SOCC) and mediate store-operated calcium entry (SOCE) in ...
Qi ZHANG, Jianxing HE, Wenju LU, Weiqiang YIN, Haihong YANG, Xiaoming XU, Daoyuan WANG   +6 more
doaj  

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Nanoparticles‐Mediated Modulation of TRP Channels: Advances and Therapeutic Potential

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
Nanoparticle‐mediated modulation of TRP channels, highlighting the interplay between external stimuli, tailored nanomaterials, and TRP channel activation across a range of physiological contexts. This review examines the roles of TRP channels in cellular signaling and disease, providing insights into how advances in nanotechnology can facilitate ...
Karina A. Foster, Noy Midler, Ori Shine, Dekel Rosenfeld   +3 more
wiley   +1 more source