Results 61 to 70 of about 7,904 (196)

The Effects of Neurosteroids, such as Pregnenolone Sulfate and its receptor, TrpM3 in the Retina. [PDF]

, 2019
Pregnenolone sulfate (PregS) is the precursor to all steroid hormones and is produced in neurons in an activity dependent manner. Studies have shown that PregS production is upregulated during certain critical periods of development, such as in the first
Webster, Corey Michael
core  

Expression of TRPC6 channels in human epithelial breast cancer cells [PDF]

, 2008
Background TRP channels have been shown to be involved in tumour generation and malignant growth. However, the expression of these channels in breast cancer remains unclear.
Arnaud Guilbert, Isabelle Dhennin-Duthille, Yassine EL Hiani, Nathalie Haren, Hafida Khorsi, Henri Sevestre, Ahmed Ahidouch, Halima Ouadid-Ahidouch, WF Wonderlin, H Ouadid-Ahidouch, H Ouadid-Ahidouch, M Potier, S Roger, S Roger, SP Fraser, IN Sergeev, JS Strobl, IN Sergeev, L Guo, L Zhuang, M Bodding, T Fixemer, M Bodding, N Prevarskaya, U Wissenbach, JB Peng, L Zhang, U Wissenbach, A Dietrich, J Soboloff, M Trebak, R Inoue, Y Yu, LC Ng, A Dietrich, AJ Hill, K Kuwahara, R Guinamard, S Thebault, Y El Hiani, SP Ethier, AB Parekh, A Dietrich, S Thebault, BK Stringer, F Mello de Queiroz, EL Ding, V Lehen'kyi, SM Vazquez   +48 more
core   +2 more sources

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation

Molecular Metabolism, 2018
Objective: Diabetic retinopathy (DR) is induced by an accumulation of reactive metabolites such as ROS, RNS, and RCS species, which were reported to modulate the activity of cation channels of the TRPC family.
Robin Sachdeva, Andrea Schlotterer, Dagmar Schumacher, Christin Matka, Ilka Mathar, Nadine Dietrich, Rebekka Medert, Ulrich Kriebs, Jihong Lin, Peter Nawroth, Lutz Birnbaumer, Thomas Fleming, Hans-Peter Hammes, Marc Freichel   +13 more
doaj   +1 more source

Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway [PDF]

, 2017
TRPC6 plays a critical role in proteinuric kidney diseases, and TRPC3 is involved in tubulointerstitialdamage and renal fibrosis in obstructed kidneys. Podocyte loss is a characteristic event in diabetic nephropathy(DN).
Birnbaumer, Lutz, He, Xiju, Li, Shoutian, Liao, Yanhong, Liu, Benju, Xu, Benke   +5 more
core  

(-)-Englerin A-evoked Cytotoxicity is Mediated by Na+ Influx and Counteracted by Na+/K+-ATPase [PDF]

, 2016
(-)-Englerin A ((-)-EA) has a rapid and potent cytotoxic effect on several types of cancer cell that is mediated by plasma membrane ion channels containing Transient Receptor Potential Canonical 4 protein (TRPC4).
Akbulut, Alevizopoulos, Alfonso, Carson, Dietrich, Engl, Fash, Kim, Li, López-Suárez, Naylor, Plant, Radtke, Rajasekaran, Ratnayake, Reinhold, Schaefer, Selvakumar, Shankavaram, Shi, Sourbier, Storch, Strübing, Xu   +23 more
core   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, Volume 183, Issue 9, Page 2139-2165, May 2026.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Characterization of Noradrenaline-Induced Increases in Intracellular Ca2+ Levels in Chinese Hamster Ovary Cells Stably Expressing Human α1A-Adrenoceptor

Journal of Pharmacological Sciences, 2007
The mechanism for noradrenaline (NA)-induced increases in intracellular Ca2+, concentration ([Ca2+]i) and physiological significance of Na+ influx through receptor-operated channels (ROCs) and store-operated channels (SOCs) were studied in Chinese ...
Takahiro Horinouchi, Yumie Miyake, Tadashi Nishiya, Arata Nishimoto, Shoko Yorozu, Atsushi Jinno, Emi Kajita, Soichi Miwa   +7 more
doaj   +1 more source

A sensory-motor neuron type mediates proprioceptive coordination of steering in C. elegans via two TRPC channels. [PDF]

PLoS Biology, 2018
Animal locomotion is mediated by a sensory system referred to as proprioception. Defects in the proprioceptive coordination of locomotion result in uncontrolled and inefficient movements.
Jihye Yeon, Jinmahn Kim, Do-Young Kim, Hyunmin Kim, Jungha Kim, Eun Jo Du, KyeongJin Kang, Hyun-Ho Lim, Daewon Moon, Kyuhyung Kim   +9 more
doaj   +1 more source

TRPC5 channels participate in pressure-sensing in aortic baroreceptors [PDF]

, 2016
published_or_final_versio
Chen, Yang-Chao, Fung, Man-Lung, Huang, Yu, Lau, On-Chai, Lo, Chun-Yin, Rudd, John Anthony, Shen, Bing, Tjong, Yung-Wui, Wang, Hui-Chuan, Wong, Ching-On, Yao, Xiaoqiang, Yung, Wing-Ho   +11 more
core   +1 more source