Results 71 to 80 of about 4,772 (153)

Calcium Dysregulation Promotes Glioma Progression by Inhibiting STAT3 Degradation Through Blocking Chaperone‐Mediated Autophagy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Calcium dysregulation is closely associated with cancer cell proliferation, migration, and invasion. Transient receptor potential canonical 1 (TRPC1) plays an essential role in regulating calcium homeostasis. However, the role of TRPC1 in calcium dysregulation in gliomas remains incompletely understood. In this study, we demonstrate that TRPC1
Jialong Chen, Yixi Lai, Mingque Li, ZiWei Cai, Renjian Lu, Linhua Liu, Yongming Peng, Chunlai Fu, Zhefan Xie, Xueqion Zhou, Jiaxian Liu, He Zhang   +11 more
wiley   +1 more source

The Complex Role of Store Operated Calcium Entry Pathways and Related Proteins in the Function of Cardiac, Skeletal and Vascular Smooth Muscle Cells

Frontiers in Physiology, 2018
Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in response to different stimuli. Agonist-induced muscle's contraction is triggered by a cytosolic free Ca2+ concentration increase due to a rapid Ca2+ release from ...
Javier Avila-Medina, Javier Avila-Medina, Javier Avila-Medina, Isabel Mayoral-Gonzalez, Isabel Mayoral-Gonzalez, Alejandro Dominguez-Rodriguez, Alejandro Dominguez-Rodriguez, Alejandro Dominguez-Rodriguez, Isabel Gallardo-Castillo, Juan Ribas, Antonio Ordoñez, Antonio Ordoñez, Juan A. Rosado, Tarik Smani, Tarik Smani, Tarik Smani   +15 more
doaj   +1 more source

TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy

Frontiers in Pharmacology, 2018
Cardiac hypertrophy, induced by neurohumoral factors, including angiotensin II and endothelin-1, is a major predisposing factor for heart failure. These ligands can induce hypertrophic growth of neonatal rat cardiomyocytes (NRCMs) mainly through Ca2 ...
Caroline Sunggip, Caroline Sunggip, Kakeru Shimoda, Kakeru Shimoda, Sayaka Oda, Sayaka Oda, Tomohiro Tanaka, Kazuhiro Nishiyama, Supachoke Mangmool, Akiyuki Nishimura, Akiyuki Nishimura, Takuro Numaga-Tomita, Takuro Numaga-Tomita, Motohiro Nishida, Motohiro Nishida, Motohiro Nishida   +15 more
doaj   +1 more source

Three cases of steroid resistant nephrotic syndrome associated with gene mutation of transient receptor potential cation channel 6(TRPC 6)in children

, 2020
原发性肾病综合征中大约有20%的患儿出现激素耐药,其中局灶节段硬化(focal segmental glomerulosclerosis,FSGS)是其主要的病理改变,且多发生于6岁前,并在10岁内进展为ESRD[1-2]。目前已明确多种基因的突变参与FSGS的形成,尤其是编码足细胞相关蛋白的单基因突变在其中发挥重要作用[3]。
SHI Zhuo, GAO Chun-lin, XIA Zheng-kun, SUN Tao, ZHANG Pei   +4 more
openaire   +1 more source

Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains

BMC Genomics, 2006
Background The purpose of this work was to study the gene expression of transient receptor potential (TRP) channels in the mouse. The application of a standardized and quantitative technique, TaqMan RT-PCR, should give information about the pattern and ...
Krüger Jana, Bisping Frederike, Kunert-Keil Christiane, Brinkmeier Heinrich   +3 more
doaj   +1 more source

TRPC1 expression and distribution in rat hearts

European Journal of Histochemistry, 2009
Transient receptor potential canonical (TRPC) proteins have been identified as a family of plasma membrane calcium-permeable channels. TRPC proteins can be activated by various stimuli and act as cellular sensors in mammals.
W. Niu, H. Wei, Y. Zhao, Y. Jiang, P. Liu, W. Wang, H. Huang   +6 more
doaj   +1 more source

Functions of TRPs in retinal tissue in physiological and pathological conditions

Frontiers in Molecular Neuroscience
The Transient Receptor Potential (TRP) constitutes a family of channels subdivided into seven subfamilies: Ankyrin (TRPA), Canonical (TRPC), Melastatin (TRPM), Mucolipin (TRPML), no-mechano-potential C (TRPN), Polycystic (TRPP), and Vanilloid (TRPV ...
Thaianne Hanah Oliveira do Nascimento, Danniel Pereira-Figueiredo, Louise Veroneze, Amanda Alves Nascimento, Francesco De Logu, Romina Nassini, Paula Campello-Costa, Adriana da Cunha Faria-Melibeu, Daniel Souza Monteiro de Araújo, Karin Costa Calaza, Karin Costa Calaza   +10 more
doaj   +1 more source

P3772CX3CR1 positive myeloid cells regulate vascular smooth muscle contraction by PLC dependent activation of transient receptor potential cation (TRPC) channels [PDF]

European Heart Journal, 2018
A Kumar, R McGeogh, H Cassidy, A Beizaei, H A Ebhardt   +4 more
openaire   +1 more source

Identification of transient receptor potential channel genes from the swimming crab, Portunus Trituberculatus, and their expression profiles under acute temperature stress

BMC Genomics
Background Temperature is an important environment factor that is critical to the survival and growth of crustaceans. However, the mechanisms by which crustaceans detect changes in temperature are still unclear.
Yichen Qian, Qiaoling Yu, Jun Zhang, Yaoyao Han, Xi Xie, Dongfa Zhu   +5 more
doaj   +1 more source

Histamine depolarizes rat intracardiac ganglion neurons through the activation of TRPC non-selective cation channels

Histamine depolarizes rat intracardiac ganglion neurons through the activation of TRPC non-selective cation channels
pdf Thesis or Dissertation European Journal of Pharmacology.
openaire