Results 71 to 80 of about 1,006,736 (177)

Cocaine self-administration in mice with forebrain knock-down of trpc5 ion channels [v1; ref status: indexed, http://f1000r.es/pb]

F1000Research, 2013
Canonical transient receptor potential (TRPC) channels are a family of non-selective cation channels that play a crucial role in modulating neuronal excitability due to their involvement in intracellular Ca2+ regulation and dendritic growth.
Matthew B Pomrenze, Michael V Baratta, Kristin C Rasmus, Brian A Cadle, Shinya Nakamura, Lutz Birnbaumer, Donald C Cooper   +6 more
doaj   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, Volume 102, Issue 4, Page 797-831, July/August 2026.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

5‐Hydroxytryptamine Distribution Alteration in Both Neuron and Synapse of Tg(SOD1*G93A)1gur Mice: A Potential Intervention Candidate Strategy for Amyotrophic Lateral Sclerosis

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This study reveals that 5‐hydroxytryptamine (5‐HT) synapses in the spinal cord and 5‐HT neurons in the brainstem of the SOD1‐G93A amyotrophic lateral sclerosis (ALS) mouse model are significantly altered, showing a decrease in pre‐symptomatic stages but a marked increase as the disease progresses.
Lijun Zhou, Menghua Li, Qi Dai, Xiwang Liu, Cheng Li, Huifeng Jiao, Haili Pan, Renshi Xu   +7 more
wiley   +1 more source

Magnetic Reprogramming of Macrophages Stimulates Phagocytosis of Breast Cancer Cells via a TRPC1‐STING Inflammatory Axis

Smart Medicine, Volume 5, Issue 3, June 2026.
Magnetic fields modulate macrophage‐cancer crosstalk through the STING‐TRPC1 axis. Exposure reprograms macrophages toward the anti‐cancer phenotype. Exposing cancer cells modulates cancer secretome to promote polarization and selective recruitment of M1‐tumoricidal macrophages, enhancing cancer immunogenicity.
Viresh Krishnan Sukumar, Yee Kit Tai, Jan Nikolas Iversen, Olivia Yeo, Anisha Praiselin Paul, Kwan Yu Wu, Lina Hsiu Kim Lim, Alfredo Franco‐Obregón   +7 more
wiley   +1 more source

TRPC channels in sensory systems [PDF]

, 2011
Transient receptor potential canonical (TRPC) channels are a family of non-selective cation channels which have a wide range of physiological functions.
Quick, K.
core  

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, Volume 183, Issue 9, Page 2139-2165, May 2026.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

TRPC3 Channels in Cardiac Fibrosis

Frontiers in Cardiovascular Medicine, 2017
Cardiac stiffness, caused by interstitial fibrosis due to deposition of extracellular matrix proteins, is thought as a major clinical outcome of heart failure with preserved ejection fraction (HFpEF).
Takuro Numaga-Tomita, Takuro Numaga-Tomita, Sayaka Oda, Sayaka Oda, Tsukasa Shimauchi, Tsukasa Shimauchi, Akiyuki Nishimura, Akiyuki Nishimura, Supachoke Mangmool, Motohiro Nishida, Motohiro Nishida, Motohiro Nishida, Motohiro Nishida   +12 more
doaj   +1 more source

Pacemaking in the heart: a redundant and robust system of mutually entrained oscillators driving cardiac automaticity

The Journal of Physiology, Volume 604, Issue 9, Page 3504-3512, 1 May 2026.
Abstract figure legend Cardiac pacemaking: the redundant and robust organ‐to‐subcellular system driving the spontaneous electrical activity responsible for regular, rhythmic excitation of the heart. Abstract The heart is an electrically controlled, mechanical pump that provides a constant supply of blood to the body.
Eilidh A. MacDonald, T. Alexander Quinn
wiley   +1 more source

Expression of Transient Receptor Potential Canonical Channel Proteins in Human Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2010
Background and objective Transient receptor potential canonical (TRPC) proteins, a group of Ca2+ permeable nonselective cation channels, are thought to constitute store-operated calcium channels (SOCC) and mediate store-operated calcium entry (SOCE) in ...
Qi ZHANG, Jianxing HE, Wenju LU, Weiqiang YIN, Haihong YANG, Xiaoming XU, Daoyuan WANG   +6 more
doaj  

TRP Channels in Angiogenesis and Other Endothelial Functions

Frontiers in Physiology, 2018
Angiogenesis is the growth of blood vessels mediated by proliferation, migration, and spatial organization of endothelial cells. This mechanism is regulated by a balance between stimulatory and inhibitory factors.
Tarik Smani, Tarik Smani, Luis J. Gómez, Sergio Regodon, Geoffrey E. Woodard, Geraldine Siegfried, Abdel-Majid Khatib, Juan A. Rosado   +7 more
doaj   +1 more source