Results 91 to 100 of about 1,006,736 (177)

TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy

Frontiers in Pharmacology, 2018
Cardiac hypertrophy, induced by neurohumoral factors, including angiotensin II and endothelin-1, is a major predisposing factor for heart failure. These ligands can induce hypertrophic growth of neonatal rat cardiomyocytes (NRCMs) mainly through Ca2 ...
Caroline Sunggip, Caroline Sunggip, Kakeru Shimoda, Kakeru Shimoda, Sayaka Oda, Sayaka Oda, Tomohiro Tanaka, Kazuhiro Nishiyama, Supachoke Mangmool, Akiyuki Nishimura, Akiyuki Nishimura, Takuro Numaga-Tomita, Takuro Numaga-Tomita, Motohiro Nishida, Motohiro Nishida, Motohiro Nishida   +15 more
doaj   +1 more source

Three cases of steroid resistant nephrotic syndrome associated with gene mutation of transient receptor potential cation channel 6(TRPC 6)in children

, 2020
原发性肾病综合征中大约有20%的患儿出现激素耐药,其中局灶节段硬化(focal segmental glomerulosclerosis,FSGS)是其主要的病理改变,且多发生于6岁前,并在10岁内进展为ESRD[1-2]。目前已明确多种基因的突变参与FSGS的形成,尤其是编码足细胞相关蛋白的单基因突变在其中发挥重要作用[3]。
SHI Zhuo, GAO Chun-lin, XIA Zheng-kun, SUN Tao, ZHANG Pei   +4 more
openaire   +1 more source

TRPC channels and store-operated Ca2+ entry [PDF]

, 2009
Store-operated calcium entry (SOCE) is a major mechanism for Ca2+ influx. Since SOCE was first proposed two decades ago many techniques have been used in attempting to identify the nature of store-operated Ca2+ (SOC) channels.
Salido, Ginés M., Sage, Stewart O., Rosado, Juan A.   +2 more
core   +1 more source

Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains

BMC Genomics, 2006
Background The purpose of this work was to study the gene expression of transient receptor potential (TRP) channels in the mouse. The application of a standardized and quantitative technique, TaqMan RT-PCR, should give information about the pattern and ...
Krüger Jana, Bisping Frederike, Kunert-Keil Christiane, Brinkmeier Heinrich   +3 more
doaj   +1 more source

Estimating the sensitivity of mechanosensitive ion channels to membrane strain and tension [PDF]

, 2004
Bone adapts to its environment by a process in which osteoblasts and osteocytes sense applied mechanical strain. One possible pathway for the detection of strain involves mechanosensitive channels and we sought to determine their sensitivity to membrane ...
Charras, G.T., Sims, S.M., Sims, Stephen M., Charras, Guillaume T., Williams, B.A., Williams, Beatrice A., Horton, M.A., Horton, Mike A.   +7 more
core   +1 more source

Functions of TRPs in retinal tissue in physiological and pathological conditions

Frontiers in Molecular Neuroscience
The Transient Receptor Potential (TRP) constitutes a family of channels subdivided into seven subfamilies: Ankyrin (TRPA), Canonical (TRPC), Melastatin (TRPM), Mucolipin (TRPML), no-mechano-potential C (TRPN), Polycystic (TRPP), and Vanilloid (TRPV ...
Thaianne Hanah Oliveira do Nascimento, Danniel Pereira-Figueiredo, Louise Veroneze, Amanda Alves Nascimento, Francesco De Logu, Romina Nassini, Paula Campello-Costa, Adriana da Cunha Faria-Melibeu, Daniel Souza Monteiro de Araújo, Karin Costa Calaza, Karin Costa Calaza   +10 more
doaj   +1 more source

Identification of canonical transient receptor potential (TRPC) channel proteins in native vascular smooth muscle cells

, 2009
Canonical transient receptor potential (TRPC) channels are Ca2+-permeable non-selective cation channels, which on stimulation allow influx of Na+ and Ca2+ ions into cells.
Saleh, Sohag N., Albert, Anthony P., Large, William A.   +2 more
core   +1 more source

TRPC Channels—Insight from the Drosophila Light Sensitive Channels

, 2018
The Drosophila Transient Receptor Potential (TRP) channel is the founding member of a large and diverse family of channel proteins. These channels are evolutionarily conserved from yeast to mammals and are found in many organisms and tissues.
Baruch Minke, William L. Pak, Ben Katz
core   +1 more source

P3772CX3CR1 positive myeloid cells regulate vascular smooth muscle contraction by PLC dependent activation of transient receptor potential cation (TRPC) channels [PDF]

European Heart Journal, 2018
A Kumar, R McGeogh, H Cassidy, A Beizaei, H A Ebhardt   +4 more
openaire   +1 more source

Targeting TRPC Channels for Control of Arthritis-Induced Bone Erosion

Arthritis leads to bone erosion due to an imbalance between osteoclast and osteoblast function. Our prior investigations revealed that the Ca2+-selective ion channel, Orai1, is critical for osteoclast maturation. Here, we show that the small-molecule ELP-
Groschner, Klaus, Douglas, Aidan, Tyler, Kendall, Geldenhuys, Werner, Barnett, John B, Tian, Jin Bin, Ray, Suravi, Hall, Casey, McCall, Jamie L, Bacsa, Bernadett, Berry, Kendyl, Soboloff, Jonathan, Jeon, Jaepyo, Nicewarner, Brady, Liu, Siyao, Zhu, Michael X, Blair, Harry C   +16 more
core   +1 more source