原发性肾病综合征中大约有20%的患儿出现激素耐药,其中局灶节段硬化(focal segmental glomerulosclerosis,FSGS)是其主要的病理改变,且多发生于6岁前,并在10岁内进展为ESRD[1-2]。目前已明确多种基因的突变参与FSGS的形成,尤其是编码足细胞相关蛋白的单基因突变在其中发挥重要作用[3]。
SHI Zhuo +4 more
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TRPC1 expression and distribution in rat hearts
Transient receptor potential canonical (TRPC) proteins have been identified as a family of plasma membrane calcium-permeable channels. TRPC proteins can be activated by various stimuli and act as cellular sensors in mammals.
W. Niu +6 more
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Identification of transient receptor potential channels in human atrial myocytes [PDF]
In Hong Kong Medical Journal, 2011, v. 17, suppl. 1, p. 68, abstract no. 115published_or_final_versionThe 16th Medical Resarch Conference (MRC), The University of Hong Kong, Hong Kong, China, 22 January 2011. In Hong Kong Medical Journal, 2011, v.
Lau, CP +4 more
core
Functions of TRPs in retinal tissue in physiological and pathological conditions
The Transient Receptor Potential (TRP) constitutes a family of channels subdivided into seven subfamilies: Ankyrin (TRPA), Canonical (TRPC), Melastatin (TRPM), Mucolipin (TRPML), no-mechano-potential C (TRPN), Polycystic (TRPP), and Vanilloid (TRPV ...
Thaianne Hanah Oliveira do Nascimento +10 more
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Differential expression and hypoxic regulation of adenosine receptors and TRPC channels in the developing heart. [PDF]
Objectives: To characterize the modifications of gene expression of adenosine receptors (AR), TRPC channels, HIF-1α and iNOS during the early cardiogenesis in response to chronic hypoxia exposure. Methods: 4-day-old chick embryos were subjected in ovo to
Carrupt, M.
core
P3772CX3CR1 positive myeloid cells regulate vascular smooth muscle contraction by PLC dependent activation of transient receptor potential cation (TRPC) channels [PDF]
A Kumar +4 more
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Electrophysiological characterization of store-operated and agonist-induced Ca2+ entry pathways in endothelial cells [PDF]
In endothelial cells, agonist-induced Ca2+ entry takes place via the store-operated Ca2+ entry pathway and/or via channel(s) gated by second messengers. As cell stimulation leads to both a partial Ca2+ store depletion as well as the production of second ...
Antigny, Fabrice +2 more
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Background Temperature is an important environment factor that is critical to the survival and growth of crustaceans. However, the mechanisms by which crustaceans detect changes in temperature are still unclear.
Yichen Qian +5 more
doaj +1 more source
European Journal of Pharmacology.
openaire
Optopharmacological control of TRPC channels by coumarin-caged lipids is associated with a phototoxic membrane effect [PDF]
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