Results 121 to 130 of about 4,772 (153)

Molecular hydrogen triggers TRPC4-TRPC4AP-dependent reversible calcium transients via extracellular influx. [PDF]

Theranostics
Zhao P, Li H, Cai Z, Zhang X, Wen X, Liu Z, Jiang S, Jiang X, Wang J, Dang Z, Liu M, Xie F, Ma X.   +12 more
europepmc   +1 more source

Dysregulation of Podocyte BK Channels and Nephrosis: Effects of Circulating Factors and Auxiliary β4 Subunits. [PDF]

Cells
Kim EY, Rachubik P, Dryer SE.
europepmc   +1 more source

An update on regulation of the polymodal TRPV4 channel by protein phosphorylation. [PDF]

Channels (Austin)
Parthasarathy A, Zhang DX.
europepmc   +1 more source

Physiological functions and pharmacological targeting of transient receptor potential channels. [PDF]

Pharmacol Rev
Chubanov V, Grimm C, Hill K, Schaefer M, Köttgen M, Storch U, Mederos Y Schnitzler M, Kudrina V, Erbacher A, Gudermann T.   +9 more
europepmc   +1 more source

Up-Regulation of the TRPM8 Channel Attenuates TRPC1-Mediated Store-Operated Calcium Entry in Abdominal Aortic Aneurysm. [PDF]

Biomolecules
Wang YQ, Pan M, Lin YC, Zheng SY, Chen QY, Gui LX, Lin MJ, Lin DC.   +7 more
europepmc   +1 more source

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Ultrashort nanosecond electric pulses activate a conductance in bovine adrenal chromaffin cells that involves cation entry through TRPC and NALCN channels

Archives of Biochemistry and Biophysics, 2022
In whole-cell voltage clamped bovine adrenal chromaffin cells maintained at a holding potential of -70 mV, a single 5 ns, 5 MV/m pulse elicited an inward current carried mainly by Na+ that displayed inward rectification and a reversal potential near -3 mV, a voltage consistent with a non-selective cation current.
Lisha Yang, Sophia Pierce, Thomas W. Gould, Gale L. Craviso, Normand Leblanc   +4 more
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Histamine depolarizes rat intracardiac ganglion neurons through the activation of TRPC non-selective cation channels

European Journal of Pharmacology, 2020
The cardiac plexus, which contains parasympathetic ganglia, plays an important role in regulating cardiac function. Histamine is known to excite intracardiac ganglion neurons, but the underlying mechanism is obscure. In the present study, therefore, the effect of histamine on rat intracardiac ganglion neurons was investigated using perforated patch ...
Aya, Sato, Shiho, Arichi, Fumiaki, Kojima, Toru, Hayashi, Tatsuko, Ohba, Dennis Lawrence, Cheung, Kei, Eto, Madoka, Narushima, Hideji, Murakoshi, Yoshihiro, Maruo, Yuichi, Kadoya, Junichi, Nabekura, Hitoshi, Ishibashi   +12 more
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Mechanism of Inhibition of TRPC Cation Channels by 2-Aminoethoxydiphenylborane

Molecular Pharmacology, 2005
We investigated the actions of the organoborane, 2-aminoethoxydiphenylborane (2APB), on Ca2+ signaling in wild-type human embryonic kidney (HEK) 293 cells and in HEK293 cells stably expressing canonical transient receptor potential (TRPC) channels. Previous reports have suggested that 2APB inhibits agonist activation of TRPC channels because of its ...
Jean-Philippe, Lievremont, Gary S, Bird, James W, Putney   +2 more
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The enigmatic TRPCs: multifunctional cation channels

Trends in Cell Biology, 2004
Abstract Canonical transient receptor potential (TRPC) channels are vertebrate homologs of the Drosophila photoreceptor channel. Considerable research has been carried out on the seven members of this family, particularly regarding their possible role in Ca 2+ entry.
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Functional and molecular characterization of receptor-activated cation currents in a vascular smooth muscle cell line: A role for TRPC channels.

2002
Mammalian homologues of the Drosophila transient receptor potential (TRP) protein, more specifically TRPC1-7, have been proposed to function as receptor-stimulated Ca2+ entry channels. To date, the properties of TRPC1-7 have been extensively studied in heterologous expression studies.
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