Results 101 to 110 of about 7,904 (196)
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Voltage-gated ion channels [PDF]
, 2017 The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
, +11 more
core +5 more sources
Prognostic Stratification and Subtyping of Glioblastoma Using Transient Receptor Potential Channels
Human Mutation, Volume 2026, Issue 1, 2026.Background Transient receptor potential (TRP) channels regulate Ca2+ homeostasis and tumor malignant phenotypes, whereas their prognostic relevance and therapeutic implications in glioblastoma (GBM) remain poorly characterized. Methods We curated a comprehensive compendium of 522 TRP‐related genes from MSigDB, KEGG, and GeneCards.
Runfeng Sun +6 more
wiley +1 more source
The Role of Neuro‐Immune Regulation in the Pathogenesis of Psoriasis
Journal of Immunology Research, Volume 2026, Issue 1, 2026.Psoriasis is a chronic inflammatory skin disease characterized by abnormal proliferation of epidermal cells induced by an overactive immune system. In addition to the interaction between immune cells and keratinocytes, emerging research highlights the indispensable role of peripheral sensory neurons in the initiation and progression of psoriatic ...
Xin Liu +10 more
wiley +1 more source
Frontiers in Physiology, 2018 Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in response to different stimuli. Agonist-induced muscle's contraction is triggered by a cytosolic free Ca2+ concentration increase due to a rapid Ca2+ release from ...
Javier Avila-Medina +15 more
doaj +1 more source
TRPC6 channels are required for proliferation, migration and invasion of breast cancer cell lines by modulation of Orai1 and Orai3 surface exposure [PDF]
, 2018 Transient receptor potential channels convey signaling information from a number of stimuli to a wide variety of cellular functions, mainly by inducing changes in cytosolic Ca2+ concentration. Different members of the TRPC, TRPM and TRPV subfamilies have
Diez Bello, Raquel +6 more
core +2 more sources
PKC-dependent Phosphorylation of the H1 Histamine Receptor Modulates TRPC6 Activity [PDF]
, 2014 Transient receptor potential canonical 6 (TRPC6) is a cation selective, DAG-regulated, Ca2+-permeable channel activated by the agonists of Gq-protein-coupled heptahelical receptors.
Chen, Xingjuan +7 more
core +2 more sources
TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy
Frontiers in Pharmacology, 2018 Cardiac hypertrophy, induced by neurohumoral factors, including angiotensin II and endothelin-1, is a major predisposing factor for heart failure. These ligands can induce hypertrophic growth of neonatal rat cardiomyocytes (NRCMs) mainly through Ca2 ...
Caroline Sunggip +15 more
doaj +1 more source
, 2002 Mammalian homologues of the Drosophila transient receptor potential (TRP) protein, more specifically TRPC1-7, have been proposed to function as receptor-stimulated Ca2+ entry channels. To date, the properties of TRPC1-7 have been extensively studied in heterologous expression studies.
openaire +1 more source
Structure of the full-length TRPV2 channel by cryo-EM. [PDF]
, 2016 Transient receptor potential (TRP) proteins form a superfamily Ca(2+)-permeable cation channels regulated by a range of chemical and physical stimuli. Structural analysis of a 'minimal' TRP vanilloid subtype 1 (TRPV1) elucidated a mechanism of channel ...
Cohen, Matthew R +6 more
core +2 more sources
BMC Genomics, 2006 Background The purpose of this work was to study the gene expression of transient receptor potential (TRP) channels in the mouse. The application of a standardized and quantitative technique, TaqMan RT-PCR, should give information about the pattern and ...
Krüger Jana +3 more
doaj +1 more source