Results 81 to 90 of about 1,006,736 (177)
TRP Channels Role in Pain Associated With Neurodegenerative Diseases
Frontiers in Neuroscience, 2020 Transient receptor potential (TRP) are cation channels expressed in both non-excitable and excitable cells from diverse tissues, including heart, lung, and brain.
Milena Duitama +5 more
doaj +1 more source
Advanced Healthcare Materials, Volume 15, Issue 13, 3 April 2026.This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim +6 more
wiley +1 more source
The Journal of Physiology, Volume 604, Issue 7, Page 3135-3158, 1 April 2026.Abstract figure legend In gravid human uterus smooth muscle, the oxytocin receptor (OXTR) and transient receptor potential vanilloid 4 (TRPV4) calcium channel colocalize at <40 nm by proximity ligation. TRPV4 is necessary for oxytocin‐induced calcium influx and contractility in uterine smooth muscle cells.
Daiana Fornes +4 more
wiley +1 more source
TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain [PDF]
, 2001 TRP proteins are cation channels responding to receptor-dependent activation of phospholipase C. Mammalian (TRPC) channels can form hetero-oligomeric channels in vitro, but native TRPC channel complexes have not been identified to date.
Clapham, David E +3 more
core +1 more source
Cold exposure and metabolic health: Therapeutic potential for obesity, diabetes, and beyond
Physiological Reports, Volume 14, Issue 7, April 2026.Abstract Cold exposure, an inducer of brown adipose tissue thermogenesis, has been applied to relieve exercise‐induced pain and inflammation, modulate circulation and enhance metabolism. However, its role in managing metabolic diseases and the underlying molecular mechanisms remain inadequately understood.
Xirong Li +5 more
wiley +1 more source
Frontiers in Physiology, 2018 Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in response to different stimuli. Agonist-induced muscle's contraction is triggered by a cytosolic free Ca2+ concentration increase due to a rapid Ca2+ release from ...
Javier Avila-Medina +15 more
doaj +1 more source
TRPC Channels and Neuron Development, Plasticity, and Activities
, 2017 In this chapter, we mainly focus on the functions of TRPC channels in brain development, including neural progenitor proliferation, neurogenesis, neuron survival, axon guidance, dendritic morphology, synaptogenesis, and neural plasticity.
Tai, Y. +3 more
core +1 more source
Effects of TRPC1’s Lysines on Heteromeric TRPC5-TRPC1 Channel Function
CellsBackground: TRPC5 proteins form plasma membrane cation channels and are expressed in the nervous and cardiovascular systems. TRPC5 activation leads to cell depolarization and increases neuronal excitability, whereas a homologous TRPC1 inhibits TRPC5 ...
Isaac S. Demaree +5 more
doaj +1 more source
Identification and functional characterisation of a class on non-selective cation channels in Saccharomyces cerevisiae. [PDF]
, 2009 Na⁺ accumulation is a significant component in salt toxicity in plants. Although many proteins that facilitate Na⁺ flux have been identified in plants, investigations aimed at identifying the initial mechanism of Na⁺ entry into plants have failed.
Carter, Scott Anthony William
core
Vanilloid transient receptor potential cation channels: An overview [PDF]
, 2008 The mammalian branch of the Transient Receptor Potential ( TRP) superfamily of cation channels consists of 28 members. They can be subdivided in six main subfamilies: the TRPC ('Canonical'), TRPV ('Vanilloid'), TRPM ('Melastatin'), TRPP ('Polycystin ...
Vennekens, Rudi +2 more
core +1 more source