Molecular Determinants of the Sensitivity to Gq/11-Phospholipase C-dependent Gating, Gd3+ Potentiation, and Ca2+ Permeability in the Transient Receptor Potential Canonical Type 5 (TRPC5) Channel [PDF]
, 2016 Transient receptor potential canonical type 5 (TRPC5) is a Ca2+-permeable cation channel that is highly expressed in the brain and is implicated in motor coordination, innate fear behavior, and seizure genesis.
Chakraborty, Saikat Chakrabort +6 more
core +1 more source
A key role of TRPC channels in the regulation of electromechanical activity of the developing heart [PDF]
, 2017 Aims It is well established that dysfunction of voltage-dependent ion channels results in arrhythmias and conduction disturbances in the foetal and adult heart.
Raddatz, Eric +2 more
core
Redox regulation of calcium ion channels: Chemical and physiological aspects [PDF]
, 2011 Reactive oxygen species (ROS) are increasingly recognized as second messengers in many cellular processes. While high concentrations of oxidants damage proteins, lipids and DNA, ultimately resulting in cell death, selective and reversible oxidation of ...
Bogeski, Ivan +5 more
core +1 more source
Heart Failure: Epidemiology, Pathophysiology, and Management
MedComm, Volume 7, Issue 3, March 2026.This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan +9 more
wiley +1 more source
Frontiers in Neuroanatomy, 2018 Disturbances in calcium homeostasis due to canonical transient receptor potential (TRPC) and/or store-operated calcium (SOC) channels can play a key role in a large number of brain disorders.
Juan R. Martinez-Galan +2 more
doaj +1 more source
Local Anesthetics in Cancer: Mechanisms and Translational Perspectives
MedComm – Oncology, Volume 5, Issue 1, March 2026.Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang +4 more
wiley +1 more source
F1000Research, 2013 Canonical transient receptor potential (TRPC) channels are a family of non-selective cation channels that play a crucial role in modulating neuronal excitability due to their involvement in intracellular Ca2+ regulation and dendritic growth.
Matthew B Pomrenze +6 more
doaj +1 more source
Transient receptor potential channel 1 deficiency impairs host defense and proinflammatory responses to bacterial infection by regulating protein kinase Cα signaling [PDF]
, 2015 Transient receptor potential channel 1 (TRPC1) is a nonselective cation channel that is required for Ca2+ homeostasis necessary for cellular functions. However, whether TRPC1 is involved in infectious disease remains unknown.
Birnbaumer, Lutz +12 more
core +1 more source
Nanoparticles‐Mediated Modulation of TRP Channels: Advances and Therapeutic Potential
WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.Nanoparticle‐mediated modulation of TRP channels, highlighting the interplay between external stimuli, tailored nanomaterials, and TRP channel activation across a range of physiological contexts. This review examines the roles of TRP channels in cellular signaling and disease, providing insights into how advances in nanotechnology can facilitate ...
Karina A. Foster +3 more
wiley +1 more source
TRP Channels Entering the Structural Era [PDF]
, 2013 Transient receptor potential (TRP) channels are important in many neuronal and non-neuronal physiological processes. The past 2 years have seen much progress in the use of structural biology techniques to elucidate molecular mechanisms of TRP channel ...
Gaudet, Rachelle
core +1 more source