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Effects of TRPC1’s Lysines on Heteromeric TRPC5-TRPC1 Channel Function [PDF]
CellsBackground: TRPC5 proteins form plasma membrane cation channels and are expressed in the nervous and cardiovascular systems. TRPC5 activation leads to cell depolarization and increases neuronal excitability, whereas a homologous TRPC1 inhibits TRPC5 ...
Quyen Hoang +2 more
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Classical Transient Receptor Potential 1 (TRPC1): Channel or Channel Regulator? [PDF]
Cells, 2014 In contrast to other Classical Transient Receptor Potential TRPC channels the function of TRPC1 as an ion channel is a matter of debate, because it is often difficult to obtain substantial functional signals over background in response to over-expression
Thomas Gudermann +2 more
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The Role of TRPC1 in Modulating Cancer Progression [PDF]
Cells, 2020 Calcium ions (Ca2+) play an important role as second messengers in regulating a plethora of physiological and pathological processes, including the progression of cancer.
Lori Hazlehurst +2 more
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TRPC1 channels underlie stretch-modulated sarcoplasmic reticulum calcium leak in cardiomyocytes
Frontiers in Physiology, 2022 Transient receptor potential canonical 1 (TRPC1) channels are Ca2+-permeable ion channels expressed in cardiomyocytes. An involvement of TRPC1 channels in cardiac diseases is widely established.
Frank Sachse, Chris Hunter
exaly +3 more sources
Cells, 2020 The cation channel subunit TRPC1 is strongly expressed in central neurons including neurons in the CA1 region of the hippocampus where it forms complexes with TRPC4 and TRPC5.
Alexander Dietrich, Dietrich Alexander
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Molecular architecture of the human TRPC1/C5 heteromeric channel [PDF]
Nature CommunicationsTransient receptor potential (TRP) ion channels form heteromers through combinatorial associations of distinct subunits, contributing to the diversity of TRP channel functions.
Sun-Hong Kim +7 more
doaj +2 more sources
Frontiers in Oncology, 2021 Background and ObjectivesIn China, over 90% of esophageal cancer (EC) cases are esophageal squamous cell carcinoma (ESCC). ESCC is a frequently malignant tumor with poor prognosis despite the development of comprehensive therapeutic strategies, for which
Xiaolong Wei, Li-Ying Zhang
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Up-Regulation of the TRPM8 Channel Attenuates TRPC1-Mediated Store-Operated Calcium Entry in Abdominal Aortic Aneurysm [PDF]
BiomoleculesAbdominal aortic aneurysm (AAA) is a life-threatening vascular disease characterized by vascular smooth muscle cell (VSMC) dysfunction and disrupted calcium homeostasis.
Yi-Qian Wang +7 more
doaj +2 more sources
Role of TRPC1 in the pathogenesis of depression induced by traumatic brain injury [PDF]
Frontiers in NeuroscienceBackgroundTraumatic brain injury (TBI) is one of the leading causes of mortality and disability, with many patients developing long-term sequelae. Depression is among the most common psychiatric complications following TBI, yet its underlying mechanisms ...
Qi-Hang Pan +14 more
doaj +2 more sources
Loss of endothelial TRPC1 aggravates metabolic dysfunction in obesity via disrupting adipose tissue homeostasis [PDF]
Frontiers in Molecular BiosciencesIntroductionWhile obesity exacerbates metabolic disorders through vascular endothelial dysfunction, the specific regulatory mechanisms of endothelial cells underlying this process remain poorly defined. Although the transient receptor potential canonical
Yihui Lan +7 more
doaj +2 more sources