Effects of TRPC1’s Lysines on Heteromeric TRPC5-TRPC1 Channel Function [PDF]
CellsBackground: TRPC5 proteins form plasma membrane cation channels and are expressed in the nervous and cardiovascular systems. TRPC5 activation leads to cell depolarization and increases neuronal excitability, whereas a homologous TRPC1 inhibits TRPC5 ...
Isaac S. Demaree +5 more
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The Role of TRPC1 in Modulating Cancer Progression [PDF]
Cells, 2020 Calcium ions (Ca2+) play an important role as second messengers in regulating a plethora of physiological and pathological processes, including the progression of cancer.
Osama Elzamzamy +2 more
exaly +5 more sources
Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle [PDF]
Cells, 2020 In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Miguel A. S. Martín-Aragón Baudel +3 more
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Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease [PDF]
Cells, 2018 Proteins of the TRPC family can form many homo- and heterotetrameric cation channels permeable to Na+, K+ and Ca2+. In this review, we focus on channels formed by the isoforms TRPC1, TRPC4 and TRPC5.
Aisling Minard +6 more
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Classical Transient Receptor Potential 1 (TRPC1): Channel or Channel Regulator?
Cells, 2014 In contrast to other Classical Transient Receptor Potential TRPC channels the function of TRPC1 as an ion channel is a matter of debate, because it is often difficult to obtain substantial functional signals over background in response to over-expression
Alexander Dietrich, Thomas Gudermann
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Molecular architecture of the human TRPC1/C5 heteromeric channel [PDF]
Nature CommunicationsTransient receptor potential (TRP) ion channels form heteromers through combinatorial associations of distinct subunits, contributing to the diversity of TRP channel functions.
Sun-Hong Kim +7 more
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Loss of endothelial TRPC1 aggravates metabolic dysfunction in obesity via disrupting adipose tissue homeostasis [PDF]
Frontiers in Molecular BiosciencesIntroductionWhile obesity exacerbates metabolic disorders through vascular endothelial dysfunction, the specific regulatory mechanisms of endothelial cells underlying this process remain poorly defined. Although the transient receptor potential canonical
Yihui Lan +7 more
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CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes [PDF]
Cellular and Molecular Immunology, 2016 CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia (CLL). Important functional properties are associated with CD5 expression in B cells, including signal transducer ...
Soizic Garaud +2 more
exaly +13 more sources
Conditional deletion of TRPC1 channel modulates synaptic plasticity, long term depression, and memory extinction in Fragile X syndrome mice [PDF]
iScienceSummary: Group I metabotropic glutamate receptors (mGluRs), particularly mGluR5, regulate synaptic plasticity via long-term depression (mGluR-LTD), a process implicated in declarative memory. We previously identified TRPC1, a highly expressed hippocampal
Farah Issa +7 more
doaj +2 more sources
TRPC channels contribute to endothelial dysfunction in pulmonary arterial hypertension [PDF]
Respiratory ResearchBackground- Pulmonary arterial hypertension (PAH) is a rare, fatal, and progressive pulmonary vascular disease. Pulmonary endothelial cell dysfunction is a hallmark of PAH, defined by excessive proliferation and dysregulated angiogenesis, along with ...
Anaïs Saint-Martin Willer +13 more
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