Results 11 to 20 of about 6,247 (194)

TRPC1 expression and distribution in rat hearts [PDF]

European Journal of Histochemistry, 2009
Transient receptor potential canonical (TRPC) proteins have been identified as a family of plasma membrane calcium-permeable channels. TRPC proteins can be activated by various stimuli and act as cellular sensors in mammals.
W. Niu, H. Wei, Y. Zhao, Y. Jiang, P. Liu, W. Wang, H. Huang   +6 more
doaj   +7 more sources

Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2

Neurobiology of Disease
Microglial canonical transient receptor potential channel 1 (TRPC1) has been proposed to influence neuroinflammation after cerebral ischemia and reperfusion injury (CIRI), however, the underlying mechanism remains poorly understood.
Huinan Zhang, Huifeng Zhang
exaly   +5 more sources

Revisiting TRPC1 and TRPC6 mechanosensitivity [PDF]

Pflügers Archiv - European Journal of Physiology, 2007
This article addresses whether TRPC1 or TRPC6 is an essential component of a mammalian stretch-activated mechano-sensitive Ca(2+) permeable cation channel (MscCa). We have transiently expressed TRPC1 and TRPC6 in African green monkey kidney (COS) or Chinese hamster ovary (CHO) cells and monitored the activity of the stretch-activated channels using a ...
Gottlieb, P., Folgering, J., Maroto, R., Raso, A., Wood, T. G., Kurosky, A., Bowman, C., Bichet, D., Patel, A., Sachs, F., Martinac, B., Hamill, O. P., Honore, E.   +12 more
openaire   +7 more sources

TRPC1 proteins confer PKC and phosphoinositol activation on native heteromeric TRPC1/C5 channels in vascular smooth muscle: comparative study of wild‐type and TRPC1 ^−/− mice [PDF]

The FASEB Journal, 2011
ABSTRACT Ca 2+ ‐permeable cation channels consisting of canonical transient receptor potential 1 (TRPC1) proteins mediate Ca 2+ influx pathways in vascular smooth muscle cells (VSMCs), which regulate physiological and pathological ...
Shi, Jian, Ju, Min, Abramowitz, Joel, Large, William A., Birnbaumer, Lutz, Albert, Anthony P.   +5 more
openaire   +5 more sources

Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease [PDF]

Cells, 2018
Proteins of the TRPC family can form many homo- and heterotetrameric cation channels permeable to Na+, K+ and Ca2+. In this review, we focus on channels formed by the isoforms TRPC1, TRPC4 and TRPC5.
Aisling Minard, Claudia C. Bauer, David J. Wright, Hussein N. Rubaiy, Katsuhiko Muraki, David J. Beech, Robin S. Bon   +6 more
doaj   +3 more sources

Role of TRPC1 channel in skeletal muscle function [PDF]

American Journal of Physiology-Cell Physiology, 2010
Skeletal muscle contraction is reputed not to depend on extracellular Ca2+. Indeed, stricto sensu , excitation-contraction coupling does not necessitate entry of Ca2+. However, we previously observed that, during sustained activity (repeated contractions), entry of Ca2+ is needed to maintain force production.
Zanou Nadège, Shapovalov Georges, Louis Magali, Tajeddine Nicolas, Gallo Chiara, Van Schoor Monique, Anguish Isabelle, Cao My Linh, Schakman Olivier, Dietrich Alexander, Lebacq Jean, Ruegg Urs, Roulet Emmanuelle, Birnbaumer Lutz, Gailly Philippe   +14 more
openaire   +6 more sources

Investigation of Trpa1 and Trpc1 Immunreactivities in Colon Adenocarcinomas [PDF]

Cancer Management and Research
As the normal colon epithelium differentiates into adenoma, invasive cancer and metastatic cancer, the cell acquires new characteristics such as apoptosis, proliferation, differentiation, invasion and metastasis. Many mechanisms are effective in acquiring these qualities. One of these is the regulation of the functioning of ion channels.
Ahmet Bozdag, Tuncay Kuloglu, Gokhan Artas, Suleyman Aydin   +3 more
openaire   +6 more sources

TRPC1, TRPC3, and TRPC4 in Rat Orofacial Structures [PDF]

Cells Tissues Organs, 2017
TRPC (transient receptor potential cation channel subfamily C) members are nonselective monovalent cation channels and control Ca²⁺ inflow. In this study, immunohistochemistry for TRPC1, TRPC3, and TRPC4 was performed on rat oral and craniofacial structures to elucidate their distribution and function in the peripheries.
Masatoshi, Fujita, Tadasu, Sato, Takehiro, Yajima, Eiji, Masaki, Hiroyuki, Ichikawa   +4 more
openaire   +3 more sources

Control of PTH secretion by the TRPC1 ion channel [PDF]

JCI Insight, 2020
Familial hypocalciuric hypercalcemia (FHH) is a genetic condition associated with hypocalciuria, hypercalcemia, and, in some cases, inappropriately high levels of circulating parathyroid hormone (PTH). FHH is associated with inactivating mutations in the gene encoding the Ca 2+ -sensing ...
Marta Onopiuk, Bonnie Eby, Vasyl Nesin, Peter Ngo, Megan Lerner, Caroline M. Gorvin, Victoria J. Stokes, Rajesh V. Thakker, Maria Luisa Brandi, Wenhan Chang, Mary Beth Humphrey, Leonidas Tsiokas, Kai Lau   +12 more
openaire   +6 more sources

TRPC1 regulates skeletal myoblast migration and differentiation [PDF]

Journal of Cell Science, 2008
Myoblast migration is a key step in myogenesis and regeneration. It allows myoblast alignment and their fusion into myotubes. The process has been shown to involve m-calpain or μ-calpain, two Ca2+-dependent cysteine proteases. Here we measure calpain activity in cultured cells and show a peak of activity at the beginning of the differentiation process.
Magali, Louis, Nadège, Zanou, Monique, Van Schoor, Philippe, Gailly   +3 more
openaire   +5 more sources