TRPC1 expression and distribution in rat hearts
European Journal of Histochemistry, 2009 Transient receptor potential canonical (TRPC) proteins have been identified as a family of plasma membrane calcium-permeable channels. TRPC proteins can be activated by various stimuli and act as cellular sensors in mammals.
W. Niu +6 more
doaj +6 more sources
TRPC1 regulates calcium-activated chloride channels in salivary gland cells [PDF]
Journal of Cellular Physiology, 2015 Calcium-activated chloride channel (CaCC) plays an important role in modulating epithelial secretion. It has been suggested that in salivary tissues, sustained fluid secretion is dependent on Ca2+ influx that activates ion channels such as CaCC to ...
Birnbaumer, Lutz +2 more
core +4 more sources
Neurobiology of DiseaseMicroglial canonical transient receptor potential channel 1 (TRPC1) has been proposed to influence neuroinflammation after cerebral ischemia and reperfusion injury (CIRI), however, the underlying mechanism remains poorly understood.
Huinan Zhang +6 more
doaj +3 more sources
Store-operated interactions between plasmalemmal STIM1 and TRPC1 proteins stimulate PLCβ1 to induce TRPC1 channel activation in vascular smooth muscle cells. [PDF]
The Journal of Physiology, 2016 KEY POINTS: Depletion of Ca(2+) stores activates store-operated channels (SOCs), which mediate Ca(2+) entry pathways that regulate cellular processes such as contraction, proliferation and gene expression.
Albert, AP +4 more
core +10 more sources
M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry [PDF]
iScience, 2018 Summary: Macrophage plasticity is essential for innate immunity, but in-depth signaling mechanism(s) regulating their functional phenotypes are ill-defined.
Arun Chauhan +13 more
doaj +5 more sources
TRPC1 links calcium signaling to cellular senescence in the protection against posttraumatic osteoarthritis [PDF]
JCI InsightTransient receptor potential channel 1 (TRPC1) is a widely expressed mechanosensitive ion channel located within the endoplasmic reticulum membrane, crucial for refilling depleted internal calcium stores during activation of calcium-dependent signaling ...
Meike Sambale +16 more
doaj +2 more sources
Unique responses of the fixed stoichiometric TRPC1–TRPC5 concatemer to G proteins [PDF]
Frontiers in PhysiologyTransient receptor potential canonical (TRPC)5 channel is a non-selective cation channel that plays a significant role in membrane depolarization and calcium influx. TRPC5 not only forms homotetramers itself but also heterotetramers with TRPC1.
Hana Kang, Insuk So, Insuk So
doaj +2 more sources
Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition [PDF]
Journal of Lipid ResearchAdipose tissue, an important organ involved in energy metabolism and endocrine, is closely related to animal meat quality and human health. Transient receptor potential channel 1 (TRPC1), an ion transporter, is adipocytes’ major Ca2+ entry channel ...
Yu Fu +7 more
doaj +2 more sources
Calcium Dysregulation Promotes Glioma Progression by Inhibiting STAT3 Degradation Through Blocking Chaperone-Mediated Autophagy. [PDF]
J Cell Mol MedABSTRACT Calcium dysregulation is closely associated with cancer cell proliferation, migration, and invasion. Transient receptor potential canonical 1 (TRPC1) plays an essential role in regulating calcium homeostasis. However, the role of TRPC1 in calcium dysregulation in gliomas remains incompletely understood. In this study, we demonstrate that TRPC1
Chen J +11 more
europepmc +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Transient receptor potential canonical (TRPC) channels play a role in angiogenesis. However, the involvement of TRPC1 in myocardial infarction (MI) remains unclear.
Xin Wen +9 more
doaj +1 more source