Results 21 to 30 of about 9,278 (208)

TRPC1 channels underlie stretch-modulated sarcoplasmic reticulum calcium leak in cardiomyocytes

Frontiers in Physiology, 2022
Transient receptor potential canonical 1 (TRPC1) channels are Ca2+-permeable ion channels expressed in cardiomyocytes. An involvement of TRPC1 channels in cardiac diseases is widely established.
Molly E. Streiff, Molly E. Streiff, Andrea C. Corbin, Andrea C. Corbin, Azmi A. Ahmad, Azmi A. Ahmad, Chris Hunter, Frank B. Sachse, Frank B. Sachse   +8 more
doaj   +1 more source

Transient Receptor Potential Channel 1 Potentially Serves as a Biomarker Indicating T/TNM Stages and Predicting Long-Term Prognosis in Patients With Renal Cell Carcinoma

Frontiers in Surgery, 2022
BackgroundTransient receptor potential channel 1 (TRPC1) regulates the progression of several cancers, but its clinical implication in renal cell carcinoma (RCC) has not been explored yet.
Liang Chen, Guang Shan, Minghuan Ge, Huijun Qian, Yue Xia   +4 more
doaj   +1 more source

Revisiting TRPC1 and TRPC6 mechanosensitivity [PDF]

Pflügers Archiv - European Journal of Physiology, 2007
This article addresses whether TRPC1 or TRPC6 is an essential component of a mammalian stretch-activated mechano-sensitive Ca(2+) permeable cation channel (MscCa). We have transiently expressed TRPC1 and TRPC6 in African green monkey kidney (COS) or Chinese hamster ovary (CHO) cells and monitored the activity of the stretch-activated channels using a ...
Gottlieb, P., Folgering, J., Maroto, R., Raso, A., Wood, T. G., Kurosky, A., Bowman, C., Bichet, D., Patel, A., Sachs, F., Martinac, B., Hamill, O. P., Honore, E.   +12 more
openaire   +3 more sources

TRPC1 contributes to endotoxemia-induced myocardial dysfunction via mediating myocardial apoptosis and autophagy

Pharmacological Research, 2022
Cardiac dysfunction is a vital complication of endotoxemia (ETM) with limited therapeutic options. Transient receptor potential canonical channel (TRPC)1 was involved in various heart diseases.
Wen Tian, Shao-Yuan Liu, Meng Zhang, Jing-Ru Meng, Na Tang, Ying-Da Feng, Yang Sun, Yuan-Yuan Gao, Lei Zhou, Wei Cao, Xiao-Qiang Li   +10 more
doaj   +1 more source

Screening of rosmarinic acid from Salvia miltiorrhizae acting on the novel target TRPC1 based on the ‘homology modelling–virtual screening–molecular docking–affinity assay–activity evaluation’ method

Pharmaceutical Biology, 2023
Context Salvia miltiorrhizae Bunge (Lamiaceae) is a traditional Chinese medicine (TCM) for the treatment of ‘thoracic obstruction’. Transient receptor potential canonical channel 1 (TRPC1) is a important target for myocardial injury treatment.Objective ...
Wei Quan, Yuan Wang, Yu-han Chen, Qing Shao, Yang-ze Gong, Jie-wen Hu, Wei-hai Liu, Zi-jun Wu, Jie Wang, Shan-bo Ma, Xiao-qiang Li   +10 more
doaj   +1 more source

The dynamic complexity of the TRPC1 channelosome [PDF]

Channels, 2011
A rise in cytoplasmic [Ca2+] due to store-operated Ca2+ entry (SOCE) triggers a plethora of responses, both acute and long term. This leads to the important question of how this initial signal is decoded to regulate specific cellular functions. It is now clearly established that local [Ca2+] at the site of SOCE can vary significantly from the global ...
Hwei Ling, Ong, Indu S, Ambudkar
openaire   +2 more sources

TRPC1 promotes the genesis and progression of colorectal cancer via activating CaM-mediated PI3K/AKT signaling axis

Oncogenesis, 2021
Transient receptor potential canonical (TRPC) channels are the most prominent nonselective cation channels involved in various diseases. However, the function, clinical significance, and molecular mechanism of TRPCs in colorectal cancer (CRC) progression
Yang Sun, Chen Ye, Wen Tian, Wen Ye, Yuan-Yuan Gao, Ying-Da Feng, Hui-Nan Zhang, Guang-Yuan Ma, Shou-Jia Wang, Wei Cao, Xiao-Qiang Li   +10 more
doaj   +1 more source

TRPC1 Regulates the Activity of a Voltage-Dependent Nonselective Cation Current in Hippocampal CA1 Neurons

Cells, 2020
The cation channel subunit TRPC1 is strongly expressed in central neurons including neurons in the CA1 region of the hippocampus where it forms complexes with TRPC4 and TRPC5.
Frauke Kepura, Eva Braun, Alexander Dietrich, Tim D. Plant   +3 more
doaj   +1 more source

Local Ca²+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca²+ signals required for specific cell functions. [PDF]

PLoS Biology, 2011
Store-operated Ca²+ entry (SOCE) has been associated with two types of channels: CRAC channels that require Orai1 and STIM1 and SOC channels that involve TRPC1, Orai1, and STIM1.
Kwong Tai Cheng, Xibao Liu, Hwei Ling Ong, William Swaim, Indu S Ambudkar   +4 more
doaj   +1 more source

Function of the Porcine TRPC1 Gene in Myogenesis and Muscle Growth

Cells, 2021
In animals, muscle growth is a quantitative trait controlled by multiple genes. Previously, we showed that the transient receptor potential channel 1 (TRPC1) gene was differentially expressed in muscle tissues between pig breeds with divergent growth ...
Yu Fu, Peng Shang, Bo Zhang, Xiaolong Tian, Ruixue Nie, Ran Zhang, Hao Zhang   +6 more
doaj   +1 more source