Results 21 to 30 of about 6,247 (194)

Amplification of EDHF‐type vasodilatations in TRPC1‐deficient mice [PDF]

British Journal of Pharmacology, 2010
BACKGROUND AND PURPOSETRPC1 channels are expressed in the vasculature and are putative candidates for intracellular Ca2+handling. However, little is known about their role in endothelium‐dependent vasodilatations including endothelium‐derived hyperpolarizing factor (EDHF) vasodilatations, which require activation of Ca2+‐activated K+channels (KCa).
Schmidt, Kjestine, Dubrovska, Galyna, Nielsen, Gorm, Fesus, Gabor, Uhrenholt, Torben Rene, Hansen, Pernille B. Lærkegaard, Gudermann, Thomas, Dietrich, Alexander, Gollasch, Maik, de Wit, Cor, Köhler, Ralf   +10 more
openaire   +5 more sources

Function of the Porcine TRPC1 Gene in Myogenesis and Muscle Growth [PDF]

Cells, 2021
In animals, muscle growth is a quantitative trait controlled by multiple genes. Previously, we showed that the transient receptor potential channel 1 (TRPC1) gene was differentially expressed in muscle tissues between pig breeds with divergent growth ...
Yu Fu, Peng Shang, Bo Zhang, Xiaolong Tian, Ruixue Nie, Ran Zhang, Hao Zhang   +6 more
doaj   +3 more sources

TRPC1 Ca2+-Permeable Channels in Animal Cells [PDF]

, 2007
The full-length transient receptor (TRPC)1 polypeptide is composed of about 790 amino acids, and several splice variants are known. The predicted structure and topology is of an integral membrane protein composed of six transmembrane domains, and a cytoplasmic C- and N-terminal domain.
Rychkov, G., Barritt, G.
openaire   +4 more sources

M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry [PDF]

iScience, 2018
Summary: Macrophage plasticity is essential for innate immunity, but in-depth signaling mechanism(s) regulating their functional phenotypes are ill-defined.
Arun Chauhan, Yuyang Sun, Pramod Sukumaran, Fredice O. Quenum Zangbede, Christopher N. Jondle, Atul Sharma, Dustin L. Evans, Pooja Chauhan, Randolph E. Szlabick, Mary O. Aaland, Lutz Birnbaumer, Jyotika Sharma, Brij B. Singh, Bibhuti B. Mishra   +13 more
doaj   +3 more sources

Expression and association of TRPC1 with TRPC3 during skeletal myogenesis [PDF]

Muscle & Nerve, 2011
AbstractIntroduction: TRPC1 and TRPC3 proteins are widely expressed in skeletal muscles in forming calcium‐permeable channels. Herein we characterize the expression pattern of TRPC transcripts during skeletal myogenesis in C2C12 myoblasts. Methods: We used polymerase chain reaction and Western blotting to detect expression levels, immunohistochemistry ...
Kwok-Kuen, Cheung, Simon S, Yeung, Shannon W, Au, Levina S, Lam, Zhong-Quan, Dai, Ying-Hui, Li, Ella W, Yeung   +6 more
openaire   +3 more sources

Distribution of TRPC1, TRPC3, and TRPC6 in the human thyroid [PDF]

Pathology - Research and Practice
Little is known about the protein expression of the transient receptor potential canonical (TRPC) channels 1, 3, and 6 in the thyroid. Research in human tissue is insufficient. Our aim was to investigate the distribution of TRPC1, 3, and 6 in the healthy human thyroid.Healthy samples were collected from seven nitrite pickling salt-ethanol-polyethylene ...
Kirstein, Emilie, Diebolt, Coline M., Wagner, Mathias, Bozzato, Alessandro, Federspiel, Jan M., Schaudien, Dirk, Tschernig, Thomas, Englisch, Colya N.   +7 more
openaire   +4 more sources

Conditional deletion of TRPC1 channel modulates synaptic plasticity, long term depression, and memory extinction in Fragile X syndrome mice [PDF]

iScience
Summary: Group I metabotropic glutamate receptors (mGluRs), particularly mGluR5, regulate synaptic plasticity via long-term depression (mGluR-LTD), a process implicated in declarative memory. We previously identified TRPC1, a highly expressed hippocampal
Farah Issa, Xavier Yerna, Thibaud Parpaite, Caren Jabbour, Olivier Schakman, Nicolas Tajeddine, Roberta Gualdani, Philippe Gailly   +7 more
doaj   +2 more sources

TRPC1 links calcium signaling to cellular senescence in the protection against posttraumatic osteoarthritis [PDF]

JCI Insight
Transient receptor potential channel 1 (TRPC1) is a widely expressed mechanosensitive ion channel located within the endoplasmic reticulum membrane, crucial for refilling depleted internal calcium stores during activation of calcium-dependent signaling ...
Meike Sambale, Starlee Lively, Osvaldo Espin-Garcia, Pratibha Potla, Chiara Pastrello, Sarah Bödecker, Linda Wessendorf, Simon Kleimann, Peter Paruzel, Rojiar Asgarian, Alexandra Tosun, Johanna Intemann, Jessica Bertrand, Francesco Dell’Accio, Mohit Kapoor, Thomas Pap, Joanna Sherwood   +16 more
doaj   +2 more sources

AFM imaging reveals the tetrameric structure of the TRPC1 channel [PDF]

Biochemical and Biophysical Research Communications, 2007
We have determined the subunit stoichiometry of the transient receptor potential C1 (TRPC1) channel by imaging isolated channels using atomic force microscopy (AFM). A frequency distribution of the molecular volumes of individual channel particles had two peaks, at 170 and 720 nm(3), corresponding with the expected sizes of TRPC1 monomers and tetramers,
Barrera, N P, Shaifta, Y, McFadzean, I, Ward, J P T, Henderson, R M, Edwardson, J M   +5 more
openaire   +4 more sources

Endothelial Transient Receptor Potential Canonical Channel Regulates Angiogenesis and Promotes Recovery After Myocardial Infarction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Transient receptor potential canonical (TRPC) channels play a role in angiogenesis. However, the involvement of TRPC1 in myocardial infarction (MI) remains unclear.
Xin Wen, Yidi Peng, Mengru Gao, Yuzhong Zhu, Yifei Zhu, Fan Yu, Tingting Zhou, Jing Shao, Lei Feng, Xin Ma   +9 more
doaj   +1 more source