Results 41 to 50 of about 6,247 (194)

Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes [PDF]

, 2009
In the present study the effect of phosphatidylinositol 4,5-bisphosphate (PIP2) was studied on a native TRPC1 store-operated channel (SOC) in freshly dispersed rabbit portal vein myocytes.
Saleh, Sohag N., Albert, Anthony P., Large, William A., Large, WA, Saleh, SN, Albert, AP   +5 more
core   +1 more source

Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory

Frontiers in Cellular Neuroscience, 2018
Group I metabotropic glutamate receptors, in particular mGluR5, have been implicated in various forms of synaptic plasticity that are believed to underlie declarative memory.
Sophie Lepannetier, Roberta Gualdani, Sabrina Tempesta, Olivier Schakman, François Seghers, Anna Kreis, Xavier Yerna, Amina Slimi, Marie de Clippele, Nicolas Tajeddine, Thomas Voets, Robin S. Bon, David J. Beech, Fadel Tissir, Philippe Gailly   +14 more
doaj   +1 more source

Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes [PDF]

, 2009
We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Anthony P. Albert, Saleh, Sohag N., Albert, Anthony P., Sohag N. Saleh, William A. Large, Large, William A., Large, WA, Saleh, SN, Albert, AP   +8 more
core   +1 more source

TRPC1-siRNA reduced ELF-EMF-induced neuronal differentiation and neurite outgrowth. [PDF]

, 2016
eNSCs were transfected with TRPC1-siRNA or control-siRNA for 3 days to silence TRPC1 expression. Then the cells were cultured in differentiation medium and exposed to ELF-EMF for 3 days.
Ping Deng (46708), Chuan Liu (367528), Lei Zhang (38117), Liping Pei (3181317), Gang Zhu (294781), Min Lin (17652), Mindi He (638349), Shangcheng Xu (533704), Huifeng Pi (638350), Chunhai Chen (529618), Zhou Zhou (154603), Zhengwang Cao (3181314), Min Li (12799), Qinlong Ma (529616), Zhengping Yu (296438), Yanwen Zhang (482144), Weixia Duan (762212), Yonghui Lu (638348), Min Zhong (300937)   +18 more
core   +1 more source

TRPC1 Deficiency Exacerbates Cerebral Ischemia/Reperfusion-Induced Neurological Injury by Potentiating Nox4-Derived Reactive Oxygen Species Generation

Cellular Physiology and Biochemistry, 2018
Background/Aims: Transient receptor potential cation channel 1 (TRPC1)-mediated the calcium (Ca2+) influx plays an important role in several brain disorders.
Ning Xu, Hao Meng, Tianyi Liu, Yingli Feng, Yuan Qi, Honglei Wang   +5 more
doaj   +1 more source

Increased Susceptibility to Pilocarpine-Induced Status Epilepticus and Reduced Latency in TRPC1/4 Double Knockout Mice

Neurology International, 2023
Canonical transient receptor potential channels (TRPCs) are a family of calcium-permeable cation channels. Previous studies have shown that heteromeric channels comprising TRPC1 and TRPC4 mediate epileptiform bursting in lateral septal neurons and ...
Fang Zheng, Kevin D. Phelan, U Thaung Shwe   +2 more
doaj   +1 more source

Pharmacological Differences between Native Homomeric Transient Receptor Potential Canonical Type 4 Channels and Heteromeric Transient Receptor Potential Canonical Type 1/4 Channels in Lateral Septal Neurons

Pharmaceuticals, 2023
Given the unique expression patterns and revelations of its critical involvement in a host of neurological disorders, the TRPC1/4/5 subgroup has become an intense target of drug development, and some compounds are now in clinical trials.
Kevin D. Phelan, U Thaung Shwe, Fang Zheng   +2 more
doaj   +1 more source

TRPC1: Getting physical in space [PDF]

Cell Cycle, 2013
Alteration of natural gravitational forces leads to changes in gene expression, cell growth, and cell function. External forces are sensed in cells via mechano-transduction processes that are important for initiating and mediating adaptive mechanisms.
openaire   +2 more sources

TRPC1: Subcellular Localization?

Journal of Biological Chemistry, 2010
Berbey et al. (1) recently reported that overexpressed TRPC1-YFP fusion protein is targeted to the sarcoplasmic reticulum of adult skeletal muscle fibers and operates as a calcium leak channel. This observation is in accordance with previous reports showing that the movement of TRPC1 to the plasma membrane is dependent on co-expression with TRPC4 or ...
Nicolas Tajeddine, Nadège Zanou, Monique Van Schoor, Jean Lebacq, Philippe Gailly   +4 more
openaire   +1 more source

TRPC1-Kanäle bei der druckabhängigen Aktivierung von pankreatischen Sternzellen [PDF]

, 2020
Die Quelle des Stromas im Pankreaskarzinom sind pankreatische Sternzellen (PSCs). Diese werden durch den erhöhten hydrostatischen Druck im Pankreaskarzinom aktiviert. Daran ist der Kationenkanal TRPC1 beteiligt, der in manchen Zellarten am store operated
Gruner, M. (Matthias)
core   +2 more sources