Results 41 to 50 of about 9,278 (208)
TRPC1: Getting physical in space [PDF]
Cell Cycle, 2013 Alteration of natural gravitational forces leads to changes in gene expression, cell growth, and cell function. External forces are sensed in cells via mechano-transduction processes that are important for initiating and mediating adaptive mechanisms.
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Neurology International, 2023 Canonical transient receptor potential channels (TRPCs) are a family of calcium-permeable cation channels. Previous studies have shown that heteromeric channels comprising TRPC1 and TRPC4 mediate epileptiform bursting in lateral septal neurons and ...
Fang Zheng +2 more
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Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy [PDF]
, 2014 Chronic neurohormonal and mechanical stresses are central fea-tures of heart disease. Increasing evidence supports a role forthe transient receptor potential canonical channels TRPC3 andTRPC6 in this pathophysiology.
Andersen, Asger +13 more
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TRPC1: Subcellular Localization?
Journal of Biological Chemistry, 2010 Berbey et al. (1) recently reported that overexpressed TRPC1-YFP fusion protein is targeted to the sarcoplasmic reticulum of adult skeletal muscle fibers and operates as a calcium leak channel. This observation is in accordance with previous reports showing that the movement of TRPC1 to the plasma membrane is dependent on co-expression with TRPC4 or ...
Nicolas Tajeddine +4 more
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TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells [PDF]
, 2018 BACKGROUND: Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limited efficacy at maximal tolerated
Ji, Xiaoying +10 more
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Inhibition of L-Type Ca 2+ Channels by TRPC1-STIM1 Complex Is Essential for the Protection of Dopaminergic Neurons [PDF]
, 2017 Loss of dopaminergic (DA) neurons leads to Parkinson’s disease; however, the mechanism(s) for the vulnerability of DA neurons is(are) not fully understood.
Birnbaumer, Lutz +6 more
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Amplification of EDHF‐type vasodilatations in TRPC1‐deficient mice [PDF]
British Journal of Pharmacology, 2010 BACKGROUND AND PURPOSETRPC1 channels are expressed in the vasculature and are putative candidates for intracellular Ca2+handling. However, little is known about their role in endothelium‐dependent vasodilatations including endothelium‐derived hyperpolarizing factor (EDHF) vasodilatations, which require activation of Ca2+‐activated K+channels (KCa).
Schmidt, Kjestine +10 more
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Role of TRPC1 channels in pressure-mediated activation of airway remodeling
Respiratory Research, 2019 Background Bronchoconstriction and cough, a characteristic of the asthmatic response, leads to development of compressive stresses in the airway wall. We hypothesized that progressively pathological high mechanical stress could act on mechanosensitive ...
Na Li +4 more
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High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling [PDF]
, 2014 © 2014, Springer-Verlag Berlin Heidelberg. Abstract: ORAI and stromal interaction molecule (STIM) are store-operated channel molecules that play essential roles in human physiology through a coupling mechanism of internal Ca 2+ store to Ca 2+ influx ...
Atkin, Stephen L. +14 more
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TRPC1 and ORAI1 channels in colon cancer
Cell Calcium, 2019 Colon cancer cells, like other types of cancer cells, undergo the remodeling of the intracellular Ca2+ homeostasis that contributes to cancer cell hallmarks including enhanced cell proliferation, migration, and survival. Colon cancer cells display enhanced store-operated Ca2+ entry (SOCE) compared with their non-cancer counterparts.
Villalobos, Carlos +3 more
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