Results 51 to 60 of about 6,247 (194)

Role of TRPC1 channels in pressure-mediated activation of airway remodeling

Respiratory Research, 2019
Background Bronchoconstriction and cough, a characteristic of the asthmatic response, leads to development of compressive stresses in the airway wall. We hypothesized that progressively pathological high mechanical stress could act on mechanosensitive ...
Na Li, Ye He, Gang Yang, Qian Yu, Minchao Li   +4 more
doaj   +1 more source

Canonical transient receptor potential channel 1 aggravates myocardial ischemia-and-reperfusion injury by upregulating reactive oxygen species

Journal of Pharmaceutical Analysis, 2023
The canonical transient receptor potential channel (TRPC) proteins form Ca2+-permeable cation channels that are involved in various heart diseases. However, the roles of specific TRPC proteins in myocardial ischemia/reperfusion (I/R) injury remain poorly
Hui-Nan Zhang, Meng Zhang, Wen Tian, Wei Quan, Fan Song, Shao-Yuan Liu, Xiao-Xiao Liu, Dan Mo, Yang Sun, Yuan-Yuan Gao, Wen Ye, Ying-Da Feng, Chang-Yang Xing, Chen Ye, Lei Zhou, Jing-Ru Meng, Wei Cao, Xiao-Qiang Li   +17 more
doaj   +1 more source

TRPC Channels in the SOCE Scenario

Cells, 2020
Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in Drosophila, it is well
Jose J. Lopez, Isaac Jardin, Jose Sanchez-Collado, Ginés M. Salido, Tarik Smani, Juan A. Rosado   +5 more
doaj   +1 more source

Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics

iScience, 2021
Summary: Transformation of naive macrophages into classically (M1) or alternatively (M2) activated macrophages regulates the inflammatory response. Here, we identified that distinct Ca2+ entry channels determine the IFNγ-induced M1 or IL-4-induced M2 ...
Viviane Nascimento Da Conceicao, Yuyang Sun, Karthik Ramachandran, Arun Chauhan, Amritha Raveendran, Manigandan Venkatesan, Bony DeKumar, Soumya Maity, Neelanjan Vishnu, George A. Kotsakis, Paul F. Worley, Donald L. Gill, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +14 more
doaj   +1 more source

Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels [PDF]

, 2017
The concentration of free cytosolic Ca(2+) and the voltage across the plasma membrane are major determinants of cell function. Ca(2+)-permeable non-selective cationic channels are known to regulate these parameters but understanding of these channels ...
Beech, David J., Miteva, K., Gaunt, HJ, Christmann, M., Taylor, R., Christmann, M, Yasuyuki Tanahashi, Henrot, M, Bailey, MA, Taylor, R, Bon, Robin S., Robin S. Bon, Hollie L. Appleby, Hamzah, Nurasyikin, Lynn McKeown, Richard Foster, Nurasyikin Hamzah, Cheung, S., Gaunt, Hannah J., Appleby, H., Bailey, M., Ludlow, MJ, Muraki, K., McKeown, Lynn, Beech, David J, Musialowski, KE, Waldmann, H., Bailey, Marc A., Appleby, Hollie L., Blythe, Nicola M, Tanahashi, Y, Nussbaumer, Peter, Foster, R., Gaunt, H., Musialowski, Katie E, Rubaiy, HN, Beech, D., Musialowski, Katie E., Bon, RS, Nussbaumer, P., Muraki, Katsuhiko, Nicola M. Blythe, Matthias Henrot, Marc A. Bailey, McKeown, L., Ludlow, M., Mathias Christmann, Foster, R, Roger Taylor, Muraki, K, Christmann, Mathias, Cheung, SY, Tanahashi, Y., Hamzah, N, Hamzah, N., McKeown, L, Waldmann, Herbert, Hussein N. Rubaiy, David J. Beech, Rubaiy, H., Beech, DJ, Katarina Miteva, Katsuhiko Muraki, Melanie J. Ludlow, Herbert Waldmann, Bon, R., Musialowski, K., Tanahashi, Yasuyuki, Sin Ying Cheung, Bailey, Marc A, Blythe, NM, Ludlow, Melanie J., Katie E. Musialowski, Miteva, Katarina, Bon, Robin S, Rubaiy, Hussein N, Appleby, Hollie L, Foster, Richard, Nussbaumer, P, Henrot, M., Ludlow, Melanie J, Henrot, Matthias, Waldmann, H, Blythe, Nicola M., Peter Nussbaumer, Gaunt, Hannah J, Hannah J. Gaunt, Miteva, K, Rubaiy, Hussein N., Taylor, Roger, Appleby, HL, Cheung, Sin Ying, Blythe, N.   +92 more
core   +1 more source

Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle

Cells, 2020
In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Miguel A. S. Martín-Aragón Baudel, Jian Shi, William A. Large, Anthony P. Albert   +3 more
doaj   +1 more source

Polysaccharides from Panax ginseng promote intestinal epithelial cell migration through affecting the Ca2+ related regulators

Journal of Ginseng Research, 2023
Background and aim: Panax ginseng, a key herbal medicine of replenishing Qi and tonifying Spleen, is widely used in the treatment of gastrointestinal diseases in East Asia.
Huibin Zhu, Jianhong Cao, Xinyi Liang, Meng Luo, Anrong Wang, Ling Hu, Ruliu Li   +6 more
doaj   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, EarlyView.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source