Results 51 to 60 of about 9,278 (208)

Tonantzitlolone is a Nanomolar Potency Activator of TRPC1/4/5 Channels. [PDF]

, 2018
BACKGROUND AND PURPOSE The diterpene ester tonantzitlonone (TZL) is a natural product which displays cytotoxicity towards certain types of cancer cell such as renal cell carcinoma cells.
Abramowitz, Akbulut, Alexander, Alexander, Alexander, Beech, Busch, Busch, Camacho Londono, Caropreso, Carson, Curtis, Dietrich, Fan, Gaunt, Harding, Jasper, Just, Ludlow, Muraki, Naylor, Pfeffer, Ratnayake, Rubaiy, Rubaiy, Rubaiy, Rubaiy, Sourbier, Sourbier, Storch, Vinayagam, Westlund, Wu   +32 more
core   +1 more source

Canonical transient receptor potential channel 1 aggravates myocardial ischemia-and-reperfusion injury by upregulating reactive oxygen species

Journal of Pharmaceutical Analysis, 2023
The canonical transient receptor potential channel (TRPC) proteins form Ca2+-permeable cation channels that are involved in various heart diseases. However, the roles of specific TRPC proteins in myocardial ischemia/reperfusion (I/R) injury remain poorly
Hui-Nan Zhang, Meng Zhang, Wen Tian, Wei Quan, Fan Song, Shao-Yuan Liu, Xiao-Xiao Liu, Dan Mo, Yang Sun, Yuan-Yuan Gao, Wen Ye, Ying-Da Feng, Chang-Yang Xing, Chen Ye, Lei Zhou, Jing-Ru Meng, Wei Cao, Xiao-Qiang Li   +17 more
doaj   +1 more source

Store depletion induces Gαq-mediated PLCβ1 activity to stimulate TRPC1 channels in vascular smooth muscle cells. [PDF]

, 2015
Depletion of sarcoplasmic reticulum (SR) Ca(2+) stores activates store-operated channels (SOCs) composed of canonical transient receptor potential (TRPC) 1 proteins in vascular smooth muscle cells (VSMCs), which contribute to important cellular functions.
Anthony P. Albert, Balla T., Francesc Miralles, Jian Shi, Lutz Birnbaumer, William A. Large   +5 more
core   +2 more sources

Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced relaxations and nitric oxide production in mesenteric arteries: comparative study using wild-type and TRPC1−/- mice [PDF]

, 2019
We have previously provided pharmacological evidence that stimulation of calcium-sensing receptors (CaSR) induces endothelium-dependent relaxations of rabbit mesenteric arteries through activation of heteromeric TRPV4/TRPC1 channels and nitric oxide (NO)
Alexander K. Zargaran, Anthony P. Albert, Harry Z.E. Greenberg, Ishioka N, Kazi S. Jahan, Lutz Birnbaumer, Mupanomunda MM, Simonette R.E. Carlton-Carew, Zhang ZR   +8 more
core   +2 more sources

Molecular Regulations and Functions of the Transient Receptor Potential Channels of the Islets of Langerhans and Insulinoma Cells

Cells, 2020
Insulin secretion from the β-cells of the islets of Langerhans is triggered mainly by nutrients such as glucose, and incretin hormones such as glucagon-like peptide-1 (GLP-1).
Md. Shahidul Islam
doaj   +1 more source

Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics

iScience, 2021
Summary: Transformation of naive macrophages into classically (M1) or alternatively (M2) activated macrophages regulates the inflammatory response. Here, we identified that distinct Ca2+ entry channels determine the IFNγ-induced M1 or IL-4-induced M2 ...
Viviane Nascimento Da Conceicao, Yuyang Sun, Karthik Ramachandran, Arun Chauhan, Amritha Raveendran, Manigandan Venkatesan, Bony DeKumar, Soumya Maity, Neelanjan Vishnu, George A. Kotsakis, Paul F. Worley, Donald L. Gill, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +14 more
doaj   +1 more source

Polysaccharides from Panax ginseng promote intestinal epithelial cell migration through affecting the Ca2+ related regulators

Journal of Ginseng Research, 2023
Background and aim: Panax ginseng, a key herbal medicine of replenishing Qi and tonifying Spleen, is widely used in the treatment of gastrointestinal diseases in East Asia.
Huibin Zhu, Jianhong Cao, Xinyi Liang, Meng Luo, Anrong Wang, Ling Hu, Ruliu Li   +6 more
doaj   +1 more source

(-)-Englerin A-evoked Cytotoxicity is Mediated by Na+ Influx and Counteracted by Na+/K+-ATPase [PDF]

, 2016
(-)-Englerin A ((-)-EA) has a rapid and potent cytotoxic effect on several types of cancer cell that is mediated by plasma membrane ion channels containing Transient Receptor Potential Canonical 4 protein (TRPC4).
Akbulut, Alevizopoulos, Alfonso, Carson, Dietrich, Engl, Fash, Kim, Li, López-Suárez, Naylor, Plant, Radtke, Rajasekaran, Ratnayake, Reinhold, Schaefer, Selvakumar, Shankavaram, Shi, Sourbier, Storch, Strübing, Xu   +23 more
core   +1 more source

Ion channel expression in human melanoma samples. in silico identification and experimental validation of molecular targets [PDF]

, 2019
Expression of 328 ion channel genes was investigated, by in silico analysis, in 170 human melanoma samples and controls. Ninety-one members of this gene-family (i.e., about 28%) show a significant (p 0.90 and p 90% in most cases).
D’Arcangelo, Daniela, Facchiano, Antonio, Facchiano, Francesco, Giampietri, Claudia, Marchetti, Paolo, Scatozza, Francesca   +5 more
core   +1 more source

TRPC1 proteins confer PKC and phosphoinositol activation on native heteromeric TRPC1/C5 channels in vascular smooth muscle: comparative study of wild‐type and TRPC1 ^−/− mice

The FASEB Journal, 2011
ABSTRACT Ca 2+ ‐permeable cation channels consisting of canonical transient receptor potential 1 (TRPC1) proteins mediate Ca 2+ influx pathways in vascular smooth muscle cells (VSMCs), which regulate physiological and pathological ...
Shi, Jian, Ju, Min, Abramowitz, Joel, Large, William A., Birnbaumer, Lutz, Albert, Anthony P.   +5 more
openaire   +4 more sources