Results 71 to 80 of about 9,278 (208)

Spatial memory impairment by TRPC1 depletion is ameliorated by environmental enrichment [PDF]

, 2016
published_or_final_versio
Chang, RCC, Liu, J, Luo, X, Xing, R, Xu, H, Yang, X, Zhang, Y   +6 more
core   +2 more sources

TRPC1 Deletion Causes Striatal Neuronal Cell Apoptosis and Proteomic Alterations in Mice

Frontiers in Aging Neuroscience, 2018
Transient receptor potential channel 1 (TRPC1) is widely expressed throughout the nervous system, while its biological role remains unclear. In this study, we showed that TRPC1 deletion caused striatal neuronal loss and significantly increased TUNEL ...
Dian Wang, Haitao Yu, Benhong Xu, Hua Xu, Zaijun Zhang, Xiaohu Ren, Jianhui Yuan, Jianjun Liu, Yi Guo, Peter S. Spencer, Xifei Yang   +10 more
doaj   +1 more source

TRPC1‐mediated Ca2+ signaling enhances intestinal epithelial restitution by increasing α4 association with PP2Ac after wounding

Physiological Reports, 2021
Gut epithelial restitution after superficial wounding is an important repair modality regulated by numerous factors including Ca2+ signaling and cellular polyamines.
Navneeta Rathor, Hee Kyoung Chung, Jia‐Le Song, Shelley R. Wang, Jian‐Ying Wang, Jaladanki N. Rao   +5 more
doaj   +1 more source

Modulated TRPC1 Expression Predicts Sensitivity of Breast Cancer to Doxorubicin and Magnetic Field Therapy: Segue Towards a Precision Medicine Approach

Frontiers in Oncology, 2022
Chemotherapy is the mainstream treatment modality for invasive breast cancer. Unfortunately, chemotherapy-associated adverse events can result in early termination of treatment.
Yee Kit Tai, Yee Kit Tai, Karen Ka Wing Chan, Karen Ka Wing Chan, Charlene Hui Hua Fong, Charlene Hui Hua Fong, Sharanya Ramanan, Sharanya Ramanan, Jasmine Lye Yee Yap, Jasmine Lye Yee Yap, Jocelyn Naixin Yin, Jocelyn Naixin Yin, Yun Sheng Yip, Wei Ren Tan, Angele Pei Fern Koh, Nguan Soon Tan, Nguan Soon Tan, Ching Wan Chan, Ching Wan Chan, Ruby Yun Ju Huang, Ruby Yun Ju Huang, Jing Ze Li, Jürg Fröhlich, Jürg Fröhlich, Jürg Fröhlich, Alfredo Franco-Obregón, Alfredo Franco-Obregón, Alfredo Franco-Obregón, Alfredo Franco-Obregón, Alfredo Franco-Obregón, Alfredo Franco-Obregón   +30 more
doaj   +1 more source

Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels [PDF]

, 2017
The concentration of free cytosolic Ca(2+) and the voltage across the plasma membrane are major determinants of cell function. Ca(2+)-permeable non-selective cationic channels are known to regulate these parameters but understanding of these channels ...
Appleby, HL, Bailey, MA, Beech, DJ, Blythe, NM, Bon, RS, Cheung, SY, Christmann, M, Foster, R, Gaunt, HJ, Hamzah, N, Henrot, M, Ludlow, MJ, McKeown, L, Miteva, K, Muraki, K, Musialowski, KE, Nussbaumer, P, Rubaiy, HN, Tanahashi, Y, Taylor, R, Waldmann, H   +20 more
core   +2 more sources

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway [PDF]

, 2017
TRPC6 plays a critical role in proteinuric kidney diseases, and TRPC3 is involved in tubulointerstitialdamage and renal fibrosis in obstructed kidneys. Podocyte loss is a characteristic event in diabetic nephropathy(DN).
Birnbaumer, Lutz, He, Xiju, Li, Shoutian, Liao, Yanhong, Liu, Benju, Xu, Benke   +5 more
core  

Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells [PDF]

, 2016
Voltage-dependent CaV1.2 L-type Ca2 channels (LTCC) are the main route for calcium entry in vascular smooth muscle cells (VSMC). Several studies have also determined the relevant role of store-operated Ca2 channels (SOCC) in vascular tone regulation.
Calderón Sánchez, Eva María, Castellano Orozco, Antonio Gonzalo, González-Rodríguez, Patricia, Monje Quiroga, Francisco, Ordóñez Fernández, José Antonio, Rosado, Juan Antonio, Smani Hajami, Tarik, Ávila Medina, Javier   +7 more
core   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

TRPC1 Channels Are Expressed in Pyramidal Neurons and in a Subset of Somatostatin Interneurons in the Rat Neocortex

Frontiers in Neuroanatomy, 2018
Disturbances in calcium homeostasis due to canonical transient receptor potential (TRPC) and/or store-operated calcium (SOC) channels can play a key role in a large number of brain disorders.
Juan R. Martinez-Galan, Ana Verdejo, Elena Caminos   +2 more
doaj   +1 more source