Results 71 to 80 of about 6,247 (194)
Frontiers in Neuroanatomy, 2018 Disturbances in calcium homeostasis due to canonical transient receptor potential (TRPC) and/or store-operated calcium (SOC) channels can play a key role in a large number of brain disorders.
Juan R. Martinez-Galan +2 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley +1 more source
TRPC1 is regulated by caveolin-1 and is involved in oxidized LDL-induced apoptosis of vascular smooth muscle cells [PDF]
, 2009 Oxidized low-density lipoprotein (oxLDL) induced-apoptosis of vascular cells may participate in plaque instability and rupture. We have previously shown that vascular smooth muscle cells (VSMC) stably expressing caveolin-1 were more susceptible to oxLDL ...
Gambert, Philippe +16 more
core +1 more source
Advanced Science, Volume 13, Issue 40, 17 July 2026.Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim +2 more
wiley +1 more source
, 2013 (A) Homology tree representative of similarities between the omTRPC1 ortholog and cloned full-length TRPC1 channels of other species. Branch length is percentage homology. (B) Tissue distribution of omTRPC1 and β-actin in various trout tissues.
Ed White (364949) +2 more
core +1 more source
Functional Role of Piezo1 in Regulating Whole‐Lung Vascular Reactivity
Pulmonary Circulation, Volume 16, Issue 3, July 2026.ABSTRACT Mechanosensitive cation channels expressed in pulmonary arterial smooth muscle (SMC) and endothelial (EC) cells contribute to the regulation of vasoconstriction and vasodilation of the pulmonary vasculature. Here, we report that activating Piezo1, a mechanosensitive cation channel, with Yoda1 induced a mild increase in pulmonary arterial ...
Sophia Parmisano +17 more
wiley +1 more source
TRPC1 contributes to the Ca2+-dependent regulation of adenylate cyclases [PDF]
Biochemical Journal, 2014 SOCE (store-operated Ca2+ entry) is mediated via specific plasma membrane channels in response to ER (endoplasmic reticulum) Ca2+ store depletion. This route of Ca2+ entry is central to the dynamic interplay between Ca2+ and cAMP signalling in regulating the activity of Ca2+-sensitive adenylate cyclase isoforms (AC1, AC5, AC6 and AC8).
Debbie, Willoughby +5 more
openaire +2 more sources
The role of TRPC1 on early-onset Alzheimer's Disease [PDF]
, 2022 Tez çalışmasının amacı, Erken yaşta başlayan Alzheimer hastalığına (EBAH) neden olan presenilin-1 (PSEN1) mutasyonunun oluşturulduğu hücrelerde TRPC1 geninin aşırı eksprese edildiği koşullarda depo kontrollü kalsiyum girişinin (SOCE), SOCE ilişkili ...
Kocabıyık, Mine
core
Nature CommunicationsThe TRPC1/5 heteromer exhibits electrophysiological and ligand-binding properties distinct from TRPC5 homomers, enabling tissue-specific cellular regulation.
Yixiang Chen +25 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source