Results 91 to 100 of about 6,247 (194)

Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced relaxations and nitric oxide production in mesenteric arteries: comparative study using wild-type and TRPC1−/- mice [PDF]

, 2019
We have previously provided pharmacological evidence that stimulation of calcium-sensing receptors (CaSR) induces endothelium-dependent relaxations of rabbit mesenteric arteries through activation of heteromeric TRPV4/TRPC1 channels and nitric oxide (NO)
Greenberg, Harry Z.E., Zargaran, AK, Albert, Anthony P., Jahan, Kazi S., Carlton-Carew, SRE, Birnbaumer, Lutz, Greenberg, HZE, Carlton Carew, Simonette R. E., Jahan, KS, Zargaran, Alexander K., Carlton-Carew, Simonette R. E., Greenberg, Harry Z. E., Carlton Carew, Simonette R.E., Birnbaumer, L, Albert, AP   +14 more
core   +1 more source

SUMOylation In Cerebral Ischaemia: A Dynamic, Isoform‐Specific Regulator of Neuroprotection and Injury

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Ischaemic stress has been demonstrated to induce a robust increase in SUMOylation, thereby promoting adaptive mechanisms that regulate protein relocalisation, stabilisation, degradation, and activation. Following hypoxic–ischaemic insult, both SUMO‐1 and SUMO‐2/3 conjugation increase, although the temporal dynamics and subcellular distribution of these
João M. Gissoni, Kiara F. Campos, Helena L. A. Vieira, Carlos Alexandre Netto, Luz Elena Durán‐Carabali, Helena I. Cimarosti   +5 more
wiley   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Unique responses of the fixed stoichiometric TRPC1–TRPC5 concatemer to G proteins

Frontiers in Physiology
Transient receptor potential canonical (TRPC)5 channel is a non-selective cation channel that plays a significant role in membrane depolarization and calcium influx. TRPC5 not only forms homotetramers itself but also heterotetramers with TRPC1.
Hana Kang, Insuk So, Insuk So
doaj   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

A bimodality of Caveolin1 in regulation of TRPC1 function

The FASEB Journal, 2008
Caveolar microdomain constitutes a major cellular compartment that facilitates various signal transduction events, Ca2+ influx being one. TRPC1, a plasma membrane component of Ca2+ permeable channel is known to be activated by ER store depletion. However, its mode of activation remains illusive.
Biswaranjan Pani, Brij B Singh
openaire   +1 more source

TRPC1 regulates fMLP-stimulated migration and chemotaxis of neutrophil granulocytes [PDF]

, 2015
Neutrophils form the first line of defense of the innate immune system and are rapidly recruited by chemotactic signals to sites of inflammation. Understanding the mechanisms of neutrophil chemotaxis is therefore of great interest for the potential ...
Lindemann, O., Schwab, A., Jung, F., Strodthoff, C., Horstmann, M., Nielsen, N., Schimmelpfennig, S., Heitzmann, M.   +7 more
core   +1 more source

Upregulated TRPC3 and downregulated TRPC1 channel expression during hypertension is associated with increased vascular contractility in rat

Frontiers in Physiology, 2011
Transient receptor potential C1 and C3 (TRPC1 and TRPC3) are expressed in vascular smooth muscle cells and are thought to be involved in vascular contractility.
Muzamil M Noorani, Rebecca C Noel, Sean eMarrelli, Sean eMarrelli   +3 more
doaj   +1 more source

Structural Modeling and Dynamics of the Full‐Length Homer1 Multimer

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 4, Page 947-960, April 2026.
ABSTRACT Homer proteins are modular scaffold molecules that constitute an integral part of the protein network within the postsynaptic density. Full‐length Homer1 forms a large homotetramer via a long coiled coil region, and can interact with proline‐rich target sequences with its globular EVH1 domain.
Zsófia E. Kálmán, András Czajlik, Brigitta Maruzs, Fanni Farkas, István Pap, Csilla Homonnay, Tomas Klumpler, Gyula Batta, Zoltán Gáspári, Bálint Péterfia   +9 more
wiley   +1 more source

Regulates myoblast migration and TRPC1 differentiation [PDF]

, 2008
Myoblasts migration is a key step in myogenesis and regeneration. It allows myoblasts alignment and fusion into myotubes. This process has been shown to involve m- or μ- calpains, two calcium-dependent cysteine proteases.
ED-PPP, Gailly, Philippe, Zanou, Nadège, Belgian Society of Physiology, Louis, Magali, Van Schoor, Monique, General Physiology Society   +6 more
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