VEGF-induced intracellular Ca2+ oscillations are down-regulated and do not stimulate angiogenesis in breast cancer-derived endothelial colony forming cells. [PDF]
, 2017 Endothelial colony forming cells (ECFCs) represent a population of truly endothelial precursors that promote the angiogenic switch in solid tumors, such as breast cancer (BC).
Biggiogera Marco +13 more
core +1 more source
Upregulation of TRPC1 in microglia promotes neutrophil infiltration after ischemic stroke
Brain Research BulletinNeutrophil infiltration has been linked to worse clinical outcomes after ischemic stroke. Microglia, a key type of immune-competent cell, engage in cross-talk with the infiltrating immune cells in the inflamed brain area, yet the molecular mechanisms ...
Hao Qian +7 more
doaj +1 more source
TRPC1 mediates slow excitatory synaptic transmission in hippocampal oriens/alveus interneurons
Molecular Brain, 2020 Hippocampal GABAergic interneurons play key roles in regulating principal cell activity and plasticity. Interneurons located in stratum oriens/alveus (O/A INs) receive excitatory inputs from CA1 pyramidal cells and express a Hebbian form of long-term ...
André Kougioumoutzakis +4 more
doaj +1 more source
Frontiers in Pharmacology, 2016 Acetaminophen (APAP) is a safe analgesic antipyretic drug at prescribed doses. Its overdose, however, can cause life-threatening liver damage. Though involvement of oxidative stress is widely acknowledged in APAP-induced hepatocellular death, the ...
Heba eBadr +7 more
doaj +1 more source
Investigation of Trpa1 and Trpc1 Immunreactivities in Colon Adenocarcinomas
Cancer Management and ResearchAs the normal colon epithelium differentiates into adenoma, invasive cancer and metastatic cancer, the cell acquires new characteristics such as apoptosis, proliferation, differentiation, invasion and metastasis. Many mechanisms are effective in acquiring these qualities. One of these is the regulation of the functioning of ion channels.
Ahmet Bozdag +3 more
openaire +3 more sources
Molecular Metabolism, 2018 Objective: Diabetic retinopathy (DR) is induced by an accumulation of reactive metabolites such as ROS, RNS, and RCS species, which were reported to modulate the activity of cation channels of the TRPC family.
Robin Sachdeva +13 more
doaj +1 more source
A triadin szerepe a szarkoplazmatikus retikulumból történő kalcium-felszabadulás folyamatában harántcsíkolt izmon = The role of surface membrane and sarcoplasmic reticular proteins in acquired and hereditary muscle disorders [PDF]
, 2013 A szarkoplazmatikus retikulum (SR) kalcium csatornája (RyR) több fehérjével is kölcsönhatásban áll. Ide tartozik a 95 kDa-os molekulasúlyú triadint (Trisk 95), melynek alternatív splicingjával többféle molekulasúlyú izoformája jöhet létre.
Csernoch, László József +10 more
core
TRPV4: Molecular Conductor of a Diverse Orchestra [PDF]
, 2016 Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective cation channel, originally described in 2000 by research teams led by Schultz ( Nat Cell Biol 2: 695 –702, 2000) and Liedtke ( Cell 103: 525–535, 2000).
Cibelli, Mario +5 more
core +1 more source
Store-operated calcium entry contributes to abnormal Ca2+ signalling in dystrophic mdx mouse myoblasts [PDF]
, 2015 Sarcolemma damage and activation of various calcium channels are implicated in altered Ca2+ homeostasis in muscle fibres of both Duchenne muscular dystrophy (DMD) sufferers and in the mdx mouse model of DMD.
Arkle, Stephen +9 more
core +2 more sources
TRPC1‐Mediated Ca2+ Entry Increases Lung Microvascular Permeability
The FASEB Journal, 2009 Despite the evidence that transient receptor potential canonical (TRPC1) channel can mediate Ca 2+ entry in endothelial cells the role of TRPC1 activity in the mechanism of increased lung vascular permeability remains unclear.
Mohammad Tauseef +5 more
openaire +1 more source