Results 111 to 120 of about 6,247 (194)

Fast endocytic recycling determines TRPC1–STIM1 clustering in ER–PM junctions and plasma membrane function of the channel [PDF]

, 2015
Stromal interaction molecule 1 (STIM1) senses depletion of ER–Ca2+ store and clusters in ER–PM junctions where it associates with and gates Ca2+ influx channels, Orai1 and TRPC1.
de Souza, Lorena Brito, Ambudkar, Indu S., Liu, Xibao, Ong, Hwei Ling   +3 more
core   +1 more source

Different contribution of redox-sensitive transient receptor potential channels to acetaminophen-induced death of human hepatoma cell line.

Frontiers in Pharmacology, 2016
Acetaminophen (APAP) is a safe analgesic antipyretic drug at prescribed doses. Its overdose, however, can cause life-threatening liver damage. Though involvement of oxidative stress is widely acknowledged in APAP-induced hepatocellular death, the ...
Heba eBadr, Daisuke eKozai, Reiko eSakaguchi, Reiko eSakaguchi, Tomohiro eNumata, Yasuo eMori, Yasuo eMori, Yasuo eMori   +7 more
doaj   +1 more source

TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation

Molecular Metabolism, 2018
Objective: Diabetic retinopathy (DR) is induced by an accumulation of reactive metabolites such as ROS, RNS, and RCS species, which were reported to modulate the activity of cation channels of the TRPC family.
Robin Sachdeva, Andrea Schlotterer, Dagmar Schumacher, Christin Matka, Ilka Mathar, Nadine Dietrich, Rebekka Medert, Ulrich Kriebs, Jihong Lin, Peter Nawroth, Lutz Birnbaumer, Thomas Fleming, Hans-Peter Hammes, Marc Freichel   +13 more
doaj   +1 more source

Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition

Journal of Lipid Research
Adipose tissue, an important organ involved in energy metabolism and endocrine, is closely related to animal meat quality and human health. Transient receptor potential channel 1 (TRPC1), an ion transporter, is adipocytes’ major Ca2+ entry channel ...
Yu Fu, Xin Hao, Jingru Nie, Peng Shang, Xinxing Dong, Bo Zhang, Dawei Yan, Hao Zhang   +7 more
doaj   +1 more source

Tumor necrosis factor-␣-induced TRPC1 expression amplifies store-operated Ca 2ϩ influx and endothelial permeability [PDF]

, 2020
influx in response to thrombin exposure. We observed that thrombininduced Ca 2ϩ influx in TNF-␣-stimulated HPAEC was twofold greater than in control cells.
Stephen M Vogel, Jennifer Shroff, Asrar B Malik, Setara Alamgir, Gias U Ahmmed, Biman C Paria, Chinnaswamy Tiruppathi, Chinnaswamy   +7 more
core  

TRPC1 is upregulated in bladder-innervating neurons in CYP_c rats. [PDF]

, 2013
A, B Immunocytochemistry of TRPC1 in DRG of control and CYPc rats, retrolabelled with DiI - scales bar: 50 µm. C, Quantitative analysis of colocalization of DiI and TRPC1.
Marc Freichel (70006), Pieter Uvin (439163), Rudi Vennekens (439166), Mathieu Boudes (439162), Silvia Pinto (439164), Dirk De Ridder (202024), Thomas Voets (439165), Lutz Birnbaumer (281971)   +7 more
core   +1 more source

Metabotropic glutamate receptor and TRPC1: Role in synaptic plasticity [PDF]

TRPC1 is a compelling ion channel mediating Ca²⁺ and Na⁺ influx, highly expressed in the brain, where its precise functions remain debated. Recent studies show TRPC1 is activated by mGluR5 in the hippocampus.
Issa, Farah
core  

TRPC1-5-5-5 heteromer as a sodium sensor

Biochemical and Biophysical Research Communications
The classical TRPC channel is a key Ca2+-permeable cation channel in mammalian cells. TRPC5, a non-selective cation channel, plays a vital role in membrane depolarization and calcium influx, forming both homotetramers and heterotetramers with TRPC1. In this study, we confirmed the optimal co-expression of TRPC1-5 and TRPC5-5 concatemers to investigate ...
Hana Kang, Jinhyeong Kim, Insuk So, Byoung-Cheol Lee   +3 more
openaire   +2 more sources

In vivo chararcterization of the role of TRPC1 Channel in skeletal muscle function [PDF]

, 2012
Skeletal muscle contraction is reputed not to depend on extracellular Ca2+. Indeed, stricto sensu, excitationcontraction coupling does not necessitate entry of Ca2+. However, we previously observed that, during sustained activity (repeated contractions),
Lebacq, Jean, Gallo, Chiara, Gailly, Philippe, Ruegg, Urs, Schakman, Olivier, Shapovalov, Georges, Zanou, Nadège, Birnbaumer, Lutz, Dietrich, Alexander, Measering Behavior 2012   +9 more
core  

The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca²⁺ Entry in Pulmonary Arterial Smooth Muscle Cells

Pharmaceuticals
Exposure to hypoxia results in the development of pulmonary arterial hypertension (PAH). An increase in the intracellular Ca2+ concentration ([Ca2+]i) in pulmonary artery smooth muscle cells (PASMCs) is a major trigger for pulmonary vasoconstriction and ...
Zen-Kong Dai, Yi-Chen Chen, Su-Ling Hsieh, Jwu-Lai Yeh, Jong-Hau Hsu, Bin-Nan Wu   +5 more
doaj   +1 more source