Cloning TRPC1 to enhance Calcium signal in a model of bitter taste transduction. [PDF]
, 2015 The sense of taste is used to evaluate the quality of food. In particular, animals detect at least five basic tastes: sweet, bitter, salty, umami and sour.
BARSOTTI, NOEMI
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A key role of TRPC channels in the regulation of electromechanical activity of the developing heart [PDF]
, 2017 Aims It is well established that dysfunction of voltage-dependent ion channels results in arrhythmias and conduction disturbances in the foetal and adult heart.
Raddatz, Eric +2 more
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Association of the polymorphis ms in STIM1 / ORAI1 / TRPC1 genes with the risk of calcium u rolithiasis [PDF]
, 2015 目的：寻找基质相互作用因子1（Stromalinteractionmolecule1，STIM1）、钙释放激活钙通道调节分子1（Calciumrelease-activatedcalciummodulator1，ORAI1）和瞬时受体电位阳离子通道1（Transientreceptorpotentialcationchannel1，TRPC1）基因中与泌尿系含钙结石发病有关的易感位点及可能存在的单体型，探讨这三者基因多态性与泌尿系含钙结石发病的关联性。 方法：1、采用病例-对照研究策略 ...
林敬莱
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Role of TRPC1 in the pathogenesis of depression induced by traumatic brain injury
Frontiers in NeuroscienceBackgroundTraumatic brain injury (TBI) is one of the leading causes of mortality and disability, with many patients developing long-term sequelae. Depression is among the most common psychiatric complications following TBI, yet its underlying mechanisms ...
Qi-Hang Pan +14 more
doaj +1 more source
Dystrophic cardiomyopathy: role of TRPV2 channels in stretch-induced cell damage [PDF]
, 2017 Aims Duchenne muscular dystrophy (DMD), a degenerative pathology of skeletal muscle, also induces cardiac failure and arrhythmias due to a mutation leading to the lack of the protein dystrophin.
Lorin, Charlotte +2 more
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The Effects of Neurosteroids, such as Pregnenolone Sulfate and its receptor, TrpM3 in the Retina. [PDF]
, 2019 Pregnenolone sulfate (PregS) is the precursor to all steroid hormones and is produced in neurons in an activity dependent manner. Studies have shown that PregS production is upregulated during certain critical periods of development, such as in the first
Webster, Corey Michael
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PharmaceuticalsExposure to hypoxia results in the development of pulmonary arterial hypertension (PAH). An increase in the intracellular Ca2+ concentration ([Ca2+]i) in pulmonary artery smooth muscle cells (PASMCs) is a major trigger for pulmonary vasoconstriction and ...
Zen-Kong Dai +5 more
doaj +1 more source
Differential expression and hypoxic regulation of adenosine receptors and TRPC channels in the developing heart. [PDF]
, 2012 Objectives: To characterize the modifications of gene expression of adenosine receptors (AR), TRPC channels, HIF-1α and iNOS during the early cardiogenesis in response to chronic hypoxia exposure. Methods: 4-day-old chick embryos were subjected in ovo to
Carrupt, M.
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Distribution of TRPC1, TRPC3, and TRPC6 in the human thyroid
Pathology - Research and PracticeLittle is known about the protein expression of the transient receptor potential canonical (TRPC) channels 1, 3, and 6 in the thyroid. Research in human tissue is insufficient. Our aim was to investigate the distribution of TRPC1, 3, and 6 in the healthy human thyroid.Healthy samples were collected from seven nitrite pickling salt-ethanol-polyethylene ...
Kirstein, Emilie +7 more
openaire +2 more sources
Homer/vesl proteins and their roles in CNS neurons [PDF]
, 2018 Since their initial discovery in 1997, Homer/Vesl proteins have become increasingly investigated as putative regulators of receptor and ion-channel function in the central nervous system.
Ehrengruber, Markus +3 more
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