Results 51 to 60 of about 7,904 (196)

Sociability is decreased following deletion of the _trpc4_ gene [PDF]

, 2011
Shyness and social anxiety are predominant features of some psychiatric disorders including autism, schizophrenia, anxiety and depression. Understanding the cellular and molecular determinants of sociability may reveal therapeutic approaches to treat ...
Andrew L. Varnell, Donald C. Cooper, Eric M. Ostertag, Jun-Gang Wang, Kristin C. Rasmus   +4 more
core   +2 more sources

Electron cryo-microscopy structure of the canonical TRPC4 ion channel

eLife, 2018
Canonical transient receptor channels (TRPC) are non-selective cation channels. They are involved in receptor-operated Ca2+ signaling and have been proposed to act as store-operated channels (SOC).
Deivanayagabarathy Vinayagam, Thomas Mager, Amir Apelbaum, Arne Bothe, Felipe Merino, Oliver Hofnagel, Christos Gatsogiannis, Stefan Raunser   +7 more
doaj   +1 more source

Deep Transcriptomic Profiling of M1 Macrophages Lacking Trpc3 [PDF]

, 2017
In previous studies using mice with macrophage-specific loss of TRPC3 we found a significant, selective effect of TRPC3 on the biology of M1, or inflammatory macrophages.
Atolagbe, Oluwatomisin T., Birnbaumer, Lutz, Joe, Bina, Kumarasamy, Sivarajan, Solanki, Sumeet, Vazquez, Guillermo   +5 more
core   +1 more source

Na⁺ entry through heteromeric TRPC4/C1 channels mediates (-)Englerin A-induced cytotoxicity in synovial sarcoma cells [PDF]

, 2017
The sesquiterpene (-)Englerin A (EA) is an organic compound from the plant Phyllanthus engleri which acts via heteromeric TRPC4/C1 channels to cause cytotoxicity in some types of cancer cell but not normal cells. Here we identified selective cytotoxicity
A Batova, A Beck, A Greka, A Riccio, AL Jackson, BC Fuchs, C Carson, C Sourbier, C Sourbier, CE Herzog, EL Spurrell, FJ Sulzmaier, H Al-Hussaini, H Suzuki, HN Rubaiy, J Myeong, J Myeong, JE Camacho Londono, JM David, JM Richter, KN Westlund, M Miller, MJ Ludlow, N Utsunomiya-Tate, R Ratnayake, RT Williams, T Rodrigues, U Storch, V Caropreso, VV Tsvilovskyy, Y Akbulut, Y Itoh, Z Wu   +32 more
core   +3 more sources

Clock genes regulate Ca2+ signaling and mitochondrial bioenergetics to inhibit Sjogren's disease

Arthritis &Rheumatology, Accepted Article.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjogren's disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA seq, and mitochondrial activity were used to investigate the effects of ...
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento Da Conceicao, Neelanjan Vishnu, Shankara N Varadarajan, Venugopal R. Bovilla, Rajender K Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

TRP Channels in Cancer: Signaling Mechanisms and Translational Approaches

Biomolecules, 2023
Ion channels play a crucial role in a wide range of biological processes, including cell cycle regulation and cancer progression. In particular, the transient receptor potential (TRP) family of channels has emerged as a promising therapeutic target due ...
Matilde Marini, Mustafa Titiz, Daniel Souza Monteiro de Araújo, Pierangelo Geppetti, Romina Nassini, Francesco De Logu   +5 more
doaj   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Cocaine self-administration in rats lacking a functional trpc4 gene [v1; ref status: indexed, http://f1000r.es/w9]

F1000Research, 2013
The canonical transient receptor potential (TRPC) family of Ca2+ permeable, non-selective cation channels is abundantly expressed throughout the brain, and plays a pivotal role in modulating cellular excitability.
Kristin C Rasmus, Casey E O'Neill, Ryan K Bachtell, Donald C Cooper   +3 more
doaj   +1 more source

Analysis of Mrgprb2 Receptor-Evoked Ca2+ Signaling in Bone Marrow Derived (BMMC) and Peritoneal (PMC) Mast Cells of TRPC-Deficient Mice

Frontiers in Immunology, 2020
Mast cells are a heterogeneous group of immune cells. The simplest and commonly accepted classification divides them in two groups according to their protease content. We have compared the action of diverse secretagogues on bone marrow derived (BMMC) and
Volodymyr Tsvilovskyy, Alejandra Solis-Lopez, Julia Almering, Christin Richter, Lutz Birnbaumer, Lutz Birnbaumer, Alexander Dietrich, Marc Freichel   +7 more
doaj   +1 more source

TRPC1 promotes the genesis and progression of colorectal cancer via activating CaM-mediated PI3K/AKT signaling axis

Oncogenesis, 2021
Transient receptor potential canonical (TRPC) channels are the most prominent nonselective cation channels involved in various diseases. However, the function, clinical significance, and molecular mechanism of TRPCs in colorectal cancer (CRC) progression
Yang Sun, Chen Ye, Wen Tian, Wen Ye, Yuan-Yuan Gao, Ying-Da Feng, Hui-Nan Zhang, Guang-Yuan Ma, Shou-Jia Wang, Wei Cao, Xiao-Qiang Li   +10 more
doaj   +1 more source