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Transient Receptor Potential Canonical (TRPC) Channels: Then and Now
Cells, 2020 Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC) channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there are seven TRPC channels (TRPC1–7).
Xingjuan Chen +4 more
doaj +3 more sources
The mammalian TRPC cation channels
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2004 Transient Receptor Potential-Canonical (TRPC) channels are mammalian homologs of Transient Receptor Potential (TRP), a Ca(2+)-permeable channel involved in the phospholipase C-regulated photoreceptor activation mechanism in Drosophila. The seven mammalian TRPCs constitute a family of channels which have been proposed to function as store-operated as ...
Vazquez, Guillermo +4 more
openaire +4 more sources
The photoswitchable cannabinoid azo-HU308 enables optical control of Ca<sup>2+</sup> dynamics in INS-1 β-cells via off-target effects on TRPC channels. [PDF]
FEBS Open BioLight activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Viray AEG, Frank JA.
europepmc +2 more sources
Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain. [PDF]
PLoS ONE, 2007 The canonical transient receptor potential (TRPC) channels are a family of non-selective cation channels that are activated by increases in intracellular Ca(2+) and G(q)/phospholipase C-coupled receptors.
Melissa A Fowler +4 more
doaj +1 more source
Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle. [PDF]
, 2020 In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Albert, AP +3 more
core +1 more source
Kisspeptin Depolarizes Gonadotropin-Releasing Hormone Neurons through Activation of TRPC-Like Cationic Channels [PDF]
The Journal of Neuroscience, 2008 Kisspeptin and its cognate receptor, GPR54, are critical for reproductive development and for the regulation of gonadotropin-releasing hormone (GnRH) secretion. Although kisspeptin has been found to depolarize GnRH neurons, the underlying ionic mechanism has not been elucidated.
Chunguang, Zhang +3 more
openaire +2 more sources
Activation of TRPC Cationic Channels by Mercurial Compounds Confers the Cytotoxicity of Mercury Exposure [PDF]
Toxicological Sciences, 2011 Mercury is an established worldwide environmental pollutant with well-known toxicity affecting neurodevelopment in humans, but the molecular basis of cytotoxicity and the detoxification procedure are still unclear. Here we examined the involvement of the canonical transient receptor potential (TRPC) channel in the mercury-induced cytotoxicity and the ...
Atkin, Stephen L. +5 more
openaire +3 more sources
BDNF Induces Calcium Elevations Associated WithIBDNF, a Nonselective Cationic Current Mediated by TRPC Channels [PDF]
Journal of Neurophysiology, 2007 Brain-derived neurotrophic factor (BDNF) has potent actions on hippocampal neurons, but the mechanisms that initiate its effects are poorly understood. We report here that localized BDNF application to apical dendrites of CA1 pyramidal neurons evoked transient elevations in intracellular Ca2+concentration, which are independent of membrane ...
Michelle D, Amaral, Lucas, Pozzo-Miller
openaire +2 more sources
Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics), 2021 Idiopathic nephrotic syndrome is the most common glomerulopathy in children, with a prevalence of approximately 16 per 100,000 of child population worldwide. Any chronic glomerular disease has the same type of development mechanism. Regardless of the damaging factor, after the death of a significant part of the nephrons, there occurs a steady decrease ...
S. L. Morozov, V. V. Dlin
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Role of phospholipase D and diacylglycerol in activating constitutive TRPC‐like cation channels in rabbit ear artery myocytes [PDF]
The Journal of Physiology, 2005 Previously we have described a constitutively active Ca2+‐permeable non‐selective cation channel in freshly dispersed rabbit ear artery myocytes that has similar properties to canonical transient receptor potential (TRPC) channel proteins. In the present study we have investigated the transduction pathways responsible for stimulating constitutive ...
Albert, A. P. +2 more
openaire +3 more sources