Results 41 to 50 of about 10,401,010 (296)

Analyses of Synthetic N‑Acyl Dopamine Derivatives Revealing Different Structural Requirements for Their Anti-inflammatory and Transient-Receptor-Potential-Channel-of-the-Vanilloid-Receptor-Subfamily-Subtype‑1 (TRPV1)-Activating Properties

, 2018
We studied the chemical entities within N-octanoyl dopamine (NOD) responsible for the activation of transient-receptor-potential channels of the vanilloid-receptor subtype 1 (TRPV1) and inhibition of inflammation.
Bastian Theisinger (310806), Björn B. Hofmann (5044262), Ralf Loesel (452852), Wolfgang Greffrath (310805), Björn Wängler (1801330), Eleni Stamellou (452849), Martin C. Harmsen (4389586), Handan Moerz (5044259), Marc Pretze (3131406), Julio Caballero (531146), Bernhard K. Krämer (5044253), Yingchun Li (636496), Rolf-Detlef Treede (226189), Anna-Isabelle Kälsch (5044256), Carmen Wängler (1790250), Mathias Hafner (144687), Benito A. Yard (310816), Sarah Klotz (290590), Uta Binzen (310804), Steffen Roth (496337), Prama Pallavi (577866)   +20 more
core   +1 more source

Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes [PDF]

, 2009
We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Anthony P. Albert, Saleh, Sohag N., Albert, Anthony P., Sohag N. Saleh, William A. Large, Large, William A., Large, WA, Saleh, SN, Albert, AP   +8 more
core   +1 more source

Tetrandrine Suppresses Transient Receptor Potential Cation Channel Protein 6 Overexpression- Induced Podocyte Damage via Blockage of RhoA/ROCK1 Signaling [Corrigendum]

Drug Design, Development and Therapy, 2020
Yu J, Zhu C, Yin J, et al. Drug Des Dev Ther. 2020;14:361–370.The authors have advised that in Figure 3 on page 365, the image of the Blank group was mistakenly duplicated from the NC group.Read the original ...
Yu J, Zhu C, Yin J, Yu D, Wan F, Tang X, Jiang X   +6 more
doaj  

Transient receptor potential channel TRPV4 mediates TGF-β1-induced differentiation of human ventricular fibroblasts

Cardiology Journal, 2020
BACKGROUND: Cardiac fibroblasts (CFs) are principal extracellular matrix-producing cells. In response to injury, CFs transdifferentiate into myofibroblasts. Intracellular calcium (Ca2+) signaling, involved in fibroblast proliferation and differentiation,
Min-Soo Ahn, Young Woo Eom, Ji-Eun Oh, Seung-Kuy Cha, Kyu Sang Park, Jung-Woo Son, Jun-Won Lee, Young Jin Youn, Sung Gyun Ahn, Jang-Young Kim, Seung-Hwan Lee, Junghan Yoon, Byung-Su Yoo   +12 more
doaj   +1 more source

Redox Regulation of Transient Receptor Potential Channels [PDF]

Antioxidants & Redox Signaling, 2014
Significance: Environmental and endogenous reactive species such as reactive oxygen species (ROS), reactive nitrogen species (RNS), and other electrophiles are not only known to exert toxic effects on organisms, but are also emerging as molecules that mediate cell ...
Kozai, Daisuke, Ogawa, Nozomi, Mori, Yasuo   +2 more
openaire   +2 more sources

Crosstalk Between Vascular Redox and Calcium Signaling in Hypertension Involves TRPM2 (Transient Receptor Potential Melastatin 2) Cation Channel

, 2020
Increased generation of reactive oxygen species (ROS) and altered Ca2+ handling cause vascular damage in hypertension. Mechanisms linking these systems are unclear, but TRPM2 (transient receptor potential melastatin 2) could be important because TRPM2 is
Karla B. Neves, Aikaterini Anagnostopoulou, Rhian M. Touyz, Rhéure Alves-Lopes, Silvia Lacchini, Augusto C. Montezano, Francisco J. Rios   +6 more
core   +1 more source

Function and therapeutic potential of transient receptor potential ankyrin 1 in fibrosis

Frontiers in Pharmacology, 2022
The transient receptor potential (TRP) protein superfamily is a special group of cation channels expressed in different cell types and signaling pathways.
Yicheng Wei, Yicheng Wei, Yicheng Wei, Jialuo Cai, Jialuo Cai, Ruiqiu Zhu, Ruiqiu Zhu, Ke Xu, Ke Xu, Hongchang Li, Jianxin Li   +10 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Transient Receptor Potential Channels and Calcium Signaling [PDF]

Cold Spring Harbor Perspectives in Biology, 2019
Transient receptor potential (TRP) cation channels play diverse roles in cellular Ca2+ signaling. First, as Ca2+-permeable channels that respond to a variety of stimuli, TRP channels can directly initiate cellular Ca2+ signals. Second, as nonselective cation channels, TRP channel activation leads to membrane depolarization, influencing Ca2+ influx via ...
Vangeel, Laura, Voets, Thomas
openaire   +3 more sources

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source