Results 61 to 70 of about 10,401,010 (296)

Transient Receptor Potential Canonical (TRPC) Channels: Then and Now

Cells, 2020
Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC) channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there are seven TRPC channels (TRPC1–7).
Xingjuan Chen, Gagandeep Sooch, Isaac S. Demaree, Fletcher A. White, Alexander G. Obukhov   +4 more
doaj   +1 more source

TRPM8 (transient receptor potential cation channel, subfamily M, member 8) [PDF]

, 2013
Review on TRPM8 (transient receptor potential cation channel, subfamily M, member 8), with data on DNA, on the protein encoded, and where the gene is ...
Valero, ML, Pardo, LA
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts

Pharmaceuticals, 2017
2017 marks the 20th anniversary of the molecular cloning by David Julius and colleagues (1997) of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1) [1].
Susan Huang, Arpad Szallasi
doaj   +1 more source

The role of transient receptor potential channels in metastasis

Biomedicine & Pharmacotherapy, 2023
Metastasis is the hallmark of failed tumor treatment and is typically associated with death due to cancer. Transient receptor potential (TRP) channels affect changes in intracellular calcium concentrations and participate at every stage of metastasis.
Suwen, Bai, Yuan, Wei, Rong, Liu, Yuhua, Chen, Wanling, Ma, Minghua, Wang, Li, Chen, Yumei, Luo, Juan, Du   +8 more
openaire   +2 more sources

Envolvimento do receptor de potencial transitório A1 (TRPA1) na manutenção da hiperalgesia mecânica e térmica (Frio) na inflamação persistente [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Farmacologia, Florianópolis, 2010O presente estudo investiga o papel do receptor TRPA1 no esenvolvimento e manutenção da ...
Costa, Diogo Santos Martins da
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Enhanced itch elicited by capsaicin in a chronic itch model

Molecular Pain, 2016
Chronic itch (pruritus) is an important clinical problem. However, the underlying molecular basis has yet to be understood. The Transient Receptor Potential Vanilloid 1 channel is a heat-sensitive cation channel expressed in primary sensory neurons and ...
Guang Yu PhD, Niuniu Yang MD, Fengxian Li MD, Meijuan Chen PhD, Changxiong J Guo BS, Changming Wang PhD, Danyou Hu BS, Yan Yang BS, Chan Zhu BS, Zhongli Wang PhD, Hao Shi MD, Tana Gegen MD, Ming Tang MS, Qian He MS, Qin Liu PhD, Zongxiang Tang PhD   +15 more
doaj   +1 more source

TRPV6 (transient receptor potential cation channel, subfamily V, member 6) [PDF]

, 2010
Review on TRPV6 (transient receptor potential cation channel, subfamily V, member 6), with data on DNA, on the protein encoded, and where the gene is ...
Hediger, MA, Suzuki, Y, Y Suzuki, MA Hediger   +3 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source