Results 61 to 70 of about 399,869 (302)
Drug Design, Development and Therapy, 2020 Jin Yu, Caifeng Zhu, Jiazhen Yin, Dongrong Yu, Feng Wan, Xuanli Tang, Xue Jiang Department of Nephrology, Guangxing Hospital Affiliated to ZheJiang Chinese Medical University (Key Laboratory of Zhejiang Province, Management of Kidney Disease), Hangzhou ...
Yu J +6 more
doaj
Enhanced itch elicited by capsaicin in a chronic itch model
Molecular Pain, 2016 Chronic itch (pruritus) is an important clinical problem. However, the underlying molecular basis has yet to be understood. The Transient Receptor Potential Vanilloid 1 channel is a heat-sensitive cation channel expressed in primary sensory neurons and ...
Guang Yu PhD +15 more
doaj +1 more source
Transient Receptor Potential Channels and Calcium Signaling [PDF]
Cold Spring Harbor Perspectives in Biology, 2019 Transient receptor potential (TRP) cation channels play diverse roles in cellular Ca2+ signaling. First, as Ca2+-permeable channels that respond to a variety of stimuli, TRP channels can directly initiate cellular Ca2+ signals. Second, as nonselective cation channels, TRP channel activation leads to membrane depolarization, influencing Ca2+ influx via ...
Vangeel, Laura, Voets, Thomas
openaire +3 more sources
A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho +7 more
wiley +1 more source
Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts
Pharmaceuticals, 2017 2017 marks the 20th anniversary of the molecular cloning by David Julius and colleagues (1997) of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1) [1].
Susan Huang, Arpad Szallasi
doaj +1 more source
The transient receptor potential family of ion channels [PDF]
Genome Biology, 2011 The transient receptor potential (TRP) multigene superfamily encodes integral membrane proteins that function as ion channels. Members of this family are conserved in yeast, invertebrates and vertebrates. The TRP family is subdivided into seven subfamilies: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin ...
Nilius, Bernd, Owsianik, Grzegorz
openaire +2 more sources
Envolvimento do receptor de potencial transitório A1 (TRPA1) na manutenção da hiperalgesia mecânica e térmica (Frio) na inflamação persistente [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Farmacologia, Florianópolis, 2010O presente estudo investiga o papel do receptor TRPA1 no esenvolvimento e manutenção da ...
Costa, Diogo Santos Martins da
core
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
, 2009 We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Anthony P. Albert +8 more
core +1 more source
TRPV2 (transient receptor potential cation channel, subfamily V, member 2) [PDF]
, 2012 Review on TRPV2 (transient receptor potential cation channel, subfamily V, member 2), with data on DNA, on the protein encoded, and where the gene is ...
Lehen'kyi, V, Prevarskaya, N
core +1 more source