Results 11 to 20 of about 35,721 (282)
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007 Pulmonary and systemic arterial hypertension are associated with profound alterations in Ca2+ homeostasis and smooth muscle cell proliferation. A novel class of non-selective cation channels, the transient receptor potential (TRP) channels, have emerged ...
Yuan, Jason X.-J. +2 more
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Role of Chemosensory TRP Channels in Lung Cancer [PDF]
Pharmaceuticals, 2018 Transient receptor potential (TRP) channels represent a large family of cation channels and many members of the TRP family have been shown to act as polymodal receptor molecules for irritative or potentially harmful substances.
Thomas R. H. Büch +4 more
doaj +2 more sources
Ca2+ Regulation of TRP Ion Channels [PDF]
International Journal of Molecular Sciences, 2018 Ca2+ signaling influences nearly every aspect of cellular life. Transient receptor potential (TRP) ion channels have emerged as cellular sensors for thermal, chemical and mechanical stimuli and are major contributors to Ca2+ signaling, playing an ...
Raquibul Hasan
exaly +2 more sources
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007 Since the molecular identification of the capsaicin receptor, now known as TRPV1, transient receptor potential (TRP) channels have occupied an important place in the understanding of sensory nerve function in the context of pain.
Cortright, Daniel N. +2 more
core +4 more sources
Sensing with TRP channels [PDF]
Nature Chemical Biology, 2005 Drosophila melanogaster flies carrying the trp (transient receptor potential) mutation are rapidly blinded by bright light, because of the absence of a Ca2+-permeable ion channel in their photoreceptors.
Bernd Nilius +7 more
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Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms [PDF]
Frontiers in Molecular Neuroscience, 2023 Transient receptor potential (TRP) channels are a large and diverse family of transmembrane ion channels that are widely expressed, have important physiological roles, and are associated with many human diseases.
Jian Huang +3 more
doaj +2 more sources
Role of transient receptor potential (TRP) channels in osteoarthritis: a comprehensive review [PDF]
Frontiers in PharmacologyOsteoarthritis (OA) is a chronic degenerative joint disease, primarily characterized by the degeneration of articular cartilage, synovial inflammation, and persistent pain, which severely impairs the quality of life for hundreds of millions of patients ...
Pengyan Qiao +9 more
doaj +2 more sources
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007 “Transient receptor potential” cation channels (TRP channels) play a unique role as cell sensors, are involved in a plethora of Ca2+-mediated cell functions, and play a role as “gate-keepers” in many homeostatic processes such as Ca2+ and Mg2 ...
Bernd Nilius, Nilius, Bernd
core +5 more sources
TRP Channels as Potential Drug Targets
Annual Review of Pharmacology and Toxicology, 2018 The transient receptor potential (TRP) superfamily of channels comprises a diverse group of cation channels. Four TRP channel subunits coassemble to form functional homo- or heterotetramers that pass sodium, calcium, or both in the inward direction ...
Magdalene M Moran
exaly +2 more sources
Cell Calcium, 2005 Udgivelsesdato: null-nullThe TRP ("transient receptor potential") family of ion channels now comprises more than 30 cation channels, most of which are permeable for Ca2+, and some also for Mg2+.
Owsianik, Grzegorz +2 more
core +4 more sources