Combining mass spectrometry and genetic labeling in mice to report TRP channel expression [PDF]
MethodsX, 2022 Transient receptor potential (TRP) ion channels play important roles in fundamental biological processes throughout the body of humans and mice. TRP channel dysfunction manifests in different disease states, therefore, these channels may represent ...
Philipp Wartenberg +8 more
doaj +2 more sources
Responses to transient receptor potential (TRP) channel agonists in Chlamydomonas reinhardtii [PDF]
Biology Open, 2020 Pungent substances, such as capsaicin and gingerol, activate the transient receptor potential (TRP)-V1 channel and affect the feeding behaviors of animals.
Mamoru Wada +2 more
doaj +2 more sources
Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms [PDF]
eLife, 2020 The recent proliferation of published TRP channel structures provides a foundation for understanding the diverse functional properties of this important family of ion channel proteins.
Katherine E Huffer +4 more
doaj +2 more sources
A heteromeric TRP channel that functions as a WNT-activated G protein-coupled receptor [PDF]
Nature CommunicationsThe human genome contains approximately 800 G protein-coupled receptors (GPCRs), all characterized by a common 7-transmembrane domain architecture. Here, we show that PKD1, an 11-transmembrane protein with a noncanonical transient receptor potential (TRP)
Emily P. Hardy +10 more
doaj +2 more sources
A Review on the Role of TRP Channels and Their Potential as Drug Targets_An Insight Into the TRP Channel Drug Discovery Methodologies [PDF]
Frontiers in Pharmacology, 2022 Hailong An
exaly +2 more sources
Annual Review of Biochemistry, 2007 The TRP (Transient Receptor Potential) superfamily of cation channels is remarkable in that it displays greater diversity in activation mechanisms and selectivities than any other group of ion channels. The domain organizations of some TRP proteins are also unusual, as they consist of linked channel and enzyme domains.
Kartik, Venkatachalam, Craig, Montell
openaire +3 more sources
Continuous glucose monitoring during pregnancy in healthy mice
Scientific Reports, 2021 During pregnancy, metabolic adaptations occur to maintain the balance between maternal and foetal growth, including increased insulin secretion and decreased insulin sensitivity. When the body fails to adjust, gestational diabetes mellitus develops.
Caroline Wuyts +4 more
doaj +1 more source
The Role of Membrane Lipids in Light-Activation of Drosophila TRP Channels
Biomolecules, 2022 Transient Receptor Potential (TRP) channels constitute a large superfamily of polymodal channel proteins with diverse roles in many physiological and sensory systems that function both as ionotropic and metabotropic receptors.
Rita Gutorov +5 more
doaj +1 more source
Function of TRP channels in monocytes/macrophages
Frontiers in Immunology, 2023 The transient receptor potential channel (TRP channel) family is a kind of non- specific cation channel widely distributed in various tissues and organs of the human body, including the respiratory system, cardiovascular system, immune system, etc.
Jiangbo Wu +33 more
doaj +1 more source
Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels.
PLoS ONE, 2023 Transient receptor potential (TRP) channels are activated by various extracellular and intracellular stimuli and are involved in many physiological events.
Manae Tatsumi +8 more
doaj +1 more source