Results 41 to 50 of about 35,655 (260)
A structural view of ligand-dependent activation in thermoTRP channels
Frontiers in Physiology, 2014 Transient Receptor Potential (TRP) proteins are a large family of ion channels, grouped intoseven sub-families. Although great advances have been made regarding the activation andmodulation of TRP channel activity, detailed molecular mechanisms governing
Ximena eSteinberg +3 more
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Identification of intracellular and plasma membrane calcium channel homologues in pathogenic parasites. [PDF]
PLoS ONE, 2011 Ca(2+) channels regulate many crucial processes within cells and their abnormal activity can be damaging to cell survival, suggesting that they might represent attractive therapeutic targets in pathogenic organisms.
David L Prole, Colin W Taylor
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The pharmacology of
British Journal of Pharmacology, 2014 This themed issue of the British Journal of Pharmacology contains review and research articles on recent advances in transient receptor potential (TRP) channel pharmacology. The review articles, written by a panel of distinguished experts, address the rapid progress in TRP channel research in fields as diverse as oncology, urology, dermatology ...
Peter, Holzer, Angelo A, Izzo
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Advanced Healthcare Materials, EarlyView.Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan +10 more
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Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice.
PLoS ONE, 2016 Members of the TRP superfamily of ion channels mediate mechanosensation in some organisms, and have been suggested as candidates for the mechanotransduction channel in vertebrate hair cells.
Xudong Wu +8 more
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British Journal of Pharmacology, 2014 Emerging evidence suggests that transient receptor potential (TRP) ion channels not only act as ‘polymodal cellular sensors’ on sensory neurons but are also functionally expressed by a multitude of non‐neuronal cell types. This is especially true in the skin, one of the largest organs of the body, where they appear to be critically involved in ...
Tóth, Balázs István +3 more
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Advanced Materials, EarlyView.Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou +5 more
wiley +1 more source
Journal of Lipid Research, 2018 Transient Receptor Potential (TRP) cation channels, like the TRP Vanilloid 1 (TRPV1) and TRP Ankyrin 1 (TRPA1), are expressed on primary sensory neurons. These thermosensor channels play a role in pain processing.
Éva Sághy +13 more
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Ratiometric Mycotoxin Detection in Living Plants With Dual‐Emissive Nanosensors
Advanced Materials, EarlyView.A minimally invasive microneedle patch integrates carbon dot‐embedded metal–organic frameworks as nanosensors to detect a key fungal toxin in living plants. The nanosensor produces a ratiometric fluorescence signal that enables early, non‐destructive diagnosis of fungal infection before visible symptoms, offering a new biomaterials‐based strategy for ...
Yuliang Li +9 more
wiley +1 more source
TRP Channels in Skin Biology and Pathophysiology
Pharmaceuticals, 2016 Ion channels of the Transient Receptor Potential (TRP) family mediate the influx of monovalent and/or divalent cations into cells in response to a host of chemical or physical stimuli. In the skin, TRP channels are expressed in many cell types, including
Michael J. Caterina, Zixuan Pang
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