Results 21 to 30 of about 35,655 (260)
Nature Structural & Molecular Biology, 2018 Mammalian transient receptor potential (TRP) channels mediate Ca2+ flux and voltage changes across membranes in response to environmental and cellular signals. At the plasma membrane, sensory TRPs act as neuronal detectors of physical and chemical environmental signals, and receptor-operated (metabotropic) TRPs decode extracellular neuroendocrine cues ...
Xiaoli Zhang +3 more
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Frontiers in Physiology, 2019 Ca2+ activated non-selective (CAN) cation channels have been described in cardiomyocytes since the advent of the patch clamp technique. It has been hypothesized that this type of ion channel contributes to the triggering of cardiac arrhythmias.
Andy Pironet +8 more
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VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8
Nature Communications, 2016 The temperature-sensitive TRPM8 channel is essential for cold sensing and has been linked to pathological cold hypersensitivity. Here, the authors find TRPM8 insertion in the cell membrane is mediated by VAMP7 following atypical LAMP1-containing vesicle ...
Debapriya Ghosh +12 more
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Gustatory-mediated avoidance of bacterial lipopolysaccharides via TRPA1 activation in Drosophila
eLife, 2016 Detecting pathogens and mounting immune responses upon infection is crucial for animal health. However, these responses come at a high metabolic price (McKean and Lazzaro, 2011, Kominsky et al., 2010), and avoiding pathogens before infection may be ...
Alessia Soldano +11 more
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Seminars in Immunopathology, 2015 Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex plays a protective role in daily life by removing irritants, chronic itch remains a clinical challenge. Despite urgent clinical need, itch has received relatively little research attention and its mechanisms have remained poorly understood until recently.
Shuohao, Sun, Xinzhong, Dong
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International Journal for Parasitology: Drugs and Drug Resistance, 2016 Praziquantel (PZQ) is effectively the only drug currently available for treatment and control of schistosomiasis, a disease affecting hundreds of millions of people worldwide. Many anthelmintics, likely including PZQ, target ion channels, membrane protein complexes essential for normal functioning of the neuromusculature and other tissues. Despite this
Swarna Bais, Robert M. Greenberg
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Frontiers in Immunology, 2022 BackgroundTransient Receptor Potential (TRP) channel is a kind of channel protein widely distributed in peripheral and central nervous system. They can be regulated by natural aromatic substances and serve as a therapeutic target for many diseases ...
Gujie Wu +7 more
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Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007 Since the molecular identification of the capsaicin receptor, now known as TRPV1, transient receptor potential (TRP) channels have occupied an important place in the understanding of sensory nerve function in the context of pain. Several TRP channels exhibit sensitivity to substances previously known to cause pain or pain-like sensations; these include
Cortright, Daniel N. +2 more
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BMC Neuroscience, 2013 Background Somatosensory nerve fibres arising from cell bodies within the trigeminal ganglia (TG) in the head and from a string of dorsal root ganglia (DRG) located lateral to the spinal cord convey endogenous and environmental stimuli to the central ...
Vandewauw Ine +2 more
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