Results 21 to 30 of about 1,329,018 (250)

Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol

eLife, 2019
The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation.
Justyna B Startek, Brett Boonen, Alejandro López-Requena, Ariel Talavera, Yeranddy A Alpizar, Debapriya Ghosh, Nele Van Ranst, Bernd Nilius, Thomas Voets, Karel Talavera   +9 more
doaj   +1 more source

Schistosome TRP channels: An appraisal

International Journal for Parasitology: Drugs and Drug Resistance, 2020
Ion channels underlie electrical excitability in cells and are essential for a variety of functions, most notably neuromuscular and sensory activity. They are also validated targets for a preponderance of approved anthelmintic compounds.
Swarna Bais, Robert M. Greenberg
doaj   +1 more source

Inhibition of diacylglycerol–sensitive TRPC channels by synthetic and natural steroids [PDF]

, 2012
TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca2+ signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition have ...
Kleemann, Heinz-Werner, Rütten, Hartmut, Hartmut Rütten (171202), Löhn Matthias, Thorsten Schmidt (5598), Thomas Licher (171199), Löhn, Matthias, Miehe Susanne, Dittrich Werner, Peter Crause, Carsten Strübing (171204), Schmidt, Thorsten, Miehe, Susanne, Susanne Miehe, Schmidt Thorsten, Carsten Strübing, Heinz-Werner Kleemann (171197), Peter Crause (171193), Dittrich, Werner, Licher, Thomas, Hartmut Rütten, Matthias Löhn, Strübing, Carsten, Rütten Hartmut, Matthias Löhn (171195), Strübing Carsten, Werner Dittrich, Licher Thomas, Thomas Licher, Heinz-Werner Kleemann, Werner Dittrich (171200), Kleemann Heinz-Werner, Crause, Peter, Susanne Miehe (171189), Crause Peter, Thorsten Schmidt   +35 more
core   +2 more sources

AAV9-Mediated Overexpression of TRPM4 Increases the Incidence of Stress-Induced Ventricular Arrhythmias in Mice

Frontiers in Physiology, 2019
Ca2+ activated non-selective (CAN) cation channels have been described in cardiomyocytes since the advent of the patch clamp technique. It has been hypothesized that this type of ion channel contributes to the triggering of cardiac arrhythmias.
Andy Pironet, Ninda Syam, Frone Vandewiele, Chris Van den Haute, Sara Kerselaers, Silvia Pinto, Greetje Vande Velde, Rik Gijsbers, Rudi Vennekens   +8 more
doaj   +1 more source

TRP Channels as Sensors of Aldehyde and Oxidative Stress

Biomolecules, 2021
The transient receptor potential (TRP) cation channel superfamily comprises more than 50 channels that play crucial roles in physiological processes. TRP channels are responsive to several exogenous and endogenous biomolecules, with aldehydes emerging as
Katharina E. M. Hellenthal, Laura Brabenec, Eric R. Gross, Nana-Maria Wagner   +3 more
doaj   +1 more source

Calmodulin binds to Drosophila TRP with an unexpected mode [PDF]

, 2021
Drosophila TRP is a calcium-permeable cation channel essential for fly visual signal transduction. During phototransduction, Ca2+ mediates both positive and negative feedback regulation on TRP channel activity, possibly via binding to calmodulin (CaM ...
Asteriti, Sabrina, Sun, Ziling, Hardie, Roger C., Ye, Fei, Liu, Wei, Chen, Weidi, Wan, Jun, Chen, Zijing, Zhang, Mingjie, Shen, Zeyu, Montell, Craig, Hardie, Roger C, Mingjie Zhang, Weidi Chen, Craig Montell, Roger C. Hardie, Zijing Chen, Sabrina Asteriti, Fei Ye, Ziling Sun, Jun Wan, Wei Liu, Zeyu Shen   +22 more
core   +2 more sources

Gustatory-mediated avoidance of bacterial lipopolysaccharides via TRPA1 activation in Drosophila

eLife, 2016
Detecting pathogens and mounting immune responses upon infection is crucial for animal health. However, these responses come at a high metabolic price (McKean and Lazzaro, 2011, Kominsky et al., 2010), and avoiding pathogens before infection may be ...
Alessia Soldano, Yeranddy A Alpizar, Brett Boonen, Luis Franco, Alejandro López-Requena, Guangda Liu, Natalia Mora, Emre Yaksi, Thomas Voets, Rudi Vennekens, Bassem A Hassan, Karel Talavera   +11 more
doaj   +1 more source

VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8

Nature Communications, 2016
The temperature-sensitive TRPM8 channel is essential for cold sensing and has been linked to pathological cold hypersensitivity. Here, the authors find TRPM8 insertion in the cell membrane is mediated by VAMP7 following atypical LAMP1-containing vesicle ...
Debapriya Ghosh, Silvia Pinto, Lydia Danglot, Ine Vandewauw, Andrei Segal, Nele Van Ranst, Melissa Benoit, Annelies Janssens, Rudi Vennekens, Pieter Vanden Berghe, Thierry Galli, Joris Vriens, Thomas Voets   +12 more
doaj   +1 more source

Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers [PDF]

, 2010
Trp(Nps)-Lys-NH2 derivatives, bearing alkyl or guanidine groups either at the N–terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel ...
De Vega, García-López, Fernández-Carvajal, Royo, Albericio, Ferrer-Montiel, González-Muñiz, Zaccaro   +7 more
core   +3 more sources

Shear-induced ciliary autotomy mediated by a TRP channel and a voltage-dependent calcium channel. [PDF]

iScience
Summary: Cilium, an organelle for sensory transduction and cell motility, dynamically grows and disappears depending on stimulus perception and cell-cycle progression.
Hui S, Kimura M, Kadowaki Y, Tsuji M, Inoue M, Watanabe N, Yoshimura K.   +6 more
europepmc   +2 more sources