Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice.
PLoS ONE, 2016 Members of the TRP superfamily of ion channels mediate mechanosensation in some organisms, and have been suggested as candidates for the mechanotransduction channel in vertebrate hair cells.
Xudong Wu +8 more
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TRIP database 2.0: a manually curated information hub for accessing TRP channel interaction network.
PLoS ONE, 2012 Transient receptor potential (TRP) channels are a family of Ca(2+)-permeable cation channels that play a crucial role in biological and disease processes.
Young-Cheul Shin +8 more
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Role of TRP channels in lymphatic function
Frontiers in PhysiologyAccumulating evidence establishes intracellular Ca2+ signaling as a central regulator of lymphatic endothelial function, with transient receptor potential (TRP) channels emerging as key molecular regulators that may translate mechanical, chemical, and ...
Xinyu Cao, Yen-Lin Chen
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TRP Channel Cooperation for Nociception: Therapeutic Opportunities [PDF]
, 2021 Chronic pain treatment remains a sore challenge, and in our aging society, the number of patients reporting inadequate pain relief continues to grow. Current treatment options all have their drawbacks, including limited efficacy and the propensity of ...
Dorien Bamps +7 more
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Trip with TRP: CNI-1 and SEC-24.2 act as TRP-4 channel trafficking regulators in Caenorhabditis elegans [PDF]
, 2021 Transient Receptor Potential (TRP) channels are conserved across phylogeny and function as polymodal cellular sensors. Numerous mutations have been shown to affect TRP channel function, causing inherited channelopathies, which include an expanding group ...
Lourdes, Riquelme-Dominguez
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Emergence of functional sensory subtypes as defined by transient receptor potential channel expression [PDF]
, 2007 The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception of touch, temperature, and pain. A differential expression of transient receptor potential (TRP)
Hjerling-Leffler, J +4 more
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Definition of two agonist types at the mammalian cold-activated channel TRPM8
eLife, 2016 Various TRP channels act as polymodal sensors of thermal and chemical stimuli, but the mechanisms whereby chemical ligands impact on TRP channel gating are poorly understood.
Annelies Janssens +8 more
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A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]
, 2013 TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Becker, Lars +19 more
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Phosphorylation of the Drosophila transient receptor potential ion channel is regulated by the phototransduction cascade and involves several protein kinases and phosphatases. [PDF]
PLoS ONE, 2013 Protein phosphorylation plays a cardinal role in regulating cellular processes in eukaryotes. Phosphorylation of proteins is controlled by protein kinases and phosphatases.
Olaf Voolstra +4 more
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Drosophila TRPM channel is essential for the control of extracellular magnesium levels [PDF]
, 2010 The TRPM group of cation channels plays diverse roles ranging from sensory signaling to Mg2+ homeostasis. In most metazoan organisms the TRPM subfamily is comprised of multiple members, including eight in humans. However, the Drosophila TRPM subfamily is
Vladimir Chubanov +18 more
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