Results 51 to 60 of about 1,329,018 (250)
Sensing with TRP channels [PDF]
, 2005 Drosophila melanogaster flies carrying the trp (transient receptor potential) mutation are rapidly blinded by bright light, because of the absence of a Ca2+-permeable ion channel in their photoreceptors.
Bernd Nilius +7 more
core +1 more source
Advanced Science, EarlyView.A wireless, dual‐responsive hydrogel (PVA/(PVDF‐TrFE)/BiOClBr@PDA) is developed to promote efficient regeneration of infected wounds by integrating piezoelectric stimulation with piezo‐photocatalytic pathways. Under simultaneous light and ultrasonic stimulation, the hydrogel generates therapeutic electrical cues and reactive oxygen species, disrupting ...
Baoying Dai +15 more
wiley +1 more source
K+, TRP, and CNG channel putative currents and accession numbers from CNS transcriptome.
, 2018 K+, TRP, and CNG channel putative currents and accession numbers from CNS transcriptome.
Adam J. Northcutt (5540906) +4 more
core +1 more source
Advanced Science, EarlyView.Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai +12 more
wiley +1 more source
Journal of Lipid Research, 2018 Transient Receptor Potential (TRP) cation channels, like the TRP Vanilloid 1 (TRPV1) and TRP Ankyrin 1 (TRPA1), are expressed on primary sensory neurons. These thermosensor channels play a role in pain processing.
Éva Sághy +13 more
doaj +1 more source
Mechanisms of TRP-channel mediated dopaminergic degeneration in C. elegans [PDF]
, 2014 One of the most common manifestations of dopaminergic degeneration in humans is in Parkinson’s Disease (PD). Although dopaminergic degeneration affects a significant portion of the aging population, the pathways and mechanisms underlying it have not yet ...
Popovitchenko, Tatiana
core
Advanced Science, EarlyView.Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao +9 more
wiley +1 more source
TRP Channels in Skin Biology and Pathophysiology
Pharmaceuticals, 2016 Ion channels of the Transient Receptor Potential (TRP) family mediate the influx of monovalent and/or divalent cations into cells in response to a host of chemical or physical stimuli. In the skin, TRP channels are expressed in many cell types, including
Michael J. Caterina, Zixuan Pang
doaj +1 more source
Reconstitution of lysosomal NAADP-TRP-ML1 signaling pathway and its function in TRP-ML1−/−cells
, 2011 It is well known that the mutation of TRP-ML1 (transient receptor potential-mucolipin-1) causes mucolipidosis IV, a lysosomal storage disease. Given that lysosomal nicotinic acid adenine dinucleotide phosphate (NAADP)-Ca2+release channel activity is ...
Ming Xu +3 more
core +1 more source
Advanced Science, EarlyView.A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao +9 more
wiley +1 more source