Results 21 to 30 of about 32,080 (252)
mSphere, 2023 Transient receptor potential (TRP) channels are evolutionarily conserved integral membrane proteins. They serve as crucial mediators of sensory signals and have profound effects on cellular functions.
Hongchen Wang +3 more
doaj +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007 Pulmonary and systemic arterial hypertension are associated with profound alterations in Ca(2+) homeostasis and smooth muscle cell proliferation. A novel class of non-selective cation channels, the transient receptor potential (TRP) channels, have emerged at the forefront of research into hypertensive disease states.
Firth, Amy L. +2 more
openaire +2 more sources
Nature Structural & Molecular Biology, 2018 Mammalian transient receptor potential (TRP) channels mediate Ca2+ flux and voltage changes across membranes in response to environmental and cellular signals. At the plasma membrane, sensory TRPs act as neuronal detectors of physical and chemical environmental signals, and receptor-operated (metabotropic) TRPs decode extracellular neuroendocrine cues ...
Xiaoli Zhang +3 more
openaire +2 more sources
Functional Importance of Transient Receptor Potential (TRP) Channels in Neurological Disorders
Frontiers in Cell and Developmental Biology, 2021 Transient receptor potential (TRP) channels are transmembrane protein complexes that play important roles in the physiology and pathophysiology of both the central nervous system (CNS) and the peripheral nerve system (PNS).
Kihwan Lee +5 more
doaj +1 more source
TRP Channels in Excitotoxicity. [PDF]
NeuroscientistGlutamate excitotoxicity is a central mechanism contributing to cellular dysfunction and death in various neurological disorders and diseases, such as stroke, traumatic brain injury, epilepsy, schizophrenia, addiction, mood disorders, Huntington’s disease, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, pathologic pain, and even normal ...
Zong P, Legere N, Feng J, Yue L.
europepmc +3 more sources
Pharmaceuticals, 2023 Itch (pruritus) is a sensation in the skin that provokes the desire to scratch. The sensation of itch is mediated through a subclass of primary afferent sensory neurons, termed pruriceptors, which express molecular receptors that are activated by itch ...
Merab G. Tsagareli +3 more
doaj +1 more source
Seminars in Immunopathology, 2015 Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex plays a protective role in daily life by removing irritants, chronic itch remains a clinical challenge. Despite urgent clinical need, itch has received relatively little research attention and its mechanisms have remained poorly understood until recently.
Shuohao, Sun, Xinzhong, Dong
openaire +2 more sources
Nociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain Pathologies
Pharmaceuticals, 2016 Specialized receptors belonging to the transient receptor potential (TRP) family of ligand-gated ion channels constitute the critical detectors and transducers of pain-causing stimuli.
Aaron D. Mickle +2 more
doaj +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007 Since the molecular identification of the capsaicin receptor, now known as TRPV1, transient receptor potential (TRP) channels have occupied an important place in the understanding of sensory nerve function in the context of pain. Several TRP channels exhibit sensitivity to substances previously known to cause pain or pain-like sensations; these include
Cortright, Daniel N. +2 more
openaire +3 more sources
Involvement of Neural Transient Receptor Potential Channels in Peripheral Inflammation
Frontiers in Immunology, 2020 Transient receptor potential (TRP) channels are a superfamily of non-selective cation channels that act as polymodal sensors in many tissues throughout mammalian organisms.
Harold A. Silverman +11 more
doaj +1 more source