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Transient Receptor Potential Channels and Inflammatory Bowel Disease
Frontiers in Immunology, 2020 The transient receptor potential (TRP) cation channels are present in abundance across the gastrointestinal (GI) tract, serving as detectors for a variety of stimuli and secondary transducers for G-protein coupled receptors.
Yiding Chen +8 more
doaj +1 more source
Inhibition of diacylglycerol–sensitive TRPC channels by synthetic and natural steroids [PDF]
, 2012 TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca2+ signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition have ...
Kleemann, Heinz-Werner +35 more
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Drosophila TRPM channel is essential for the control of extracellular magnesium levels [PDF]
, 2010 The TRPM group of cation channels plays diverse roles ranging from sensory signaling to Mg2+ homeostasis. In most metazoan organisms the TRPM subfamily is comprised of multiple members, including eight in humans. However, the Drosophila TRPM subfamily is
Vladimir Chubanov +18 more
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A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]
, 2013 TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Becker, Lars +19 more
core +2 more sources
Seminars in Immunopathology, 2015 Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex plays a protective role in daily life by removing irritants, chronic itch remains a clinical challenge. Despite urgent clinical need, itch has received relatively little research attention and its mechanisms have remained poorly understood until recently.
Shuohao, Sun, Xinzhong, Dong
openaire +2 more sources
Emergence of functional sensory subtypes as defined by transient receptor potential channel expression [PDF]
, 2007 The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception of touch, temperature, and pain. A differential expression of transient receptor potential (TRP)
Hjerling-Leffler, J +4 more
core +1 more source
Regulation of transient receptor potential (TRP) channels by phosphoinositides [PDF]
, 2007 This review summarizes the modulation of transient receptor potential (TRP) channels, by phosphoinositides. TRP channels are characterized by polymodal activation and a surprising complexity of regulation mechanisms.
Rohacs, Tibor +3 more
core +1 more source
TRP-channels as key integrators of lipid pathways in nociceptive neurons
, 2022 S.93-107TRP-channels are the most prominent family of ligand-gated ion channels for pain perception. In sensory neurons, TRPV1-V4, TRPA1 and TRPM8 are expressed and are responsible for the conversion of external stimuli to painful sensations.
Bennett, D.L.H. +3 more
core +2 more sources
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007 Since the molecular identification of the capsaicin receptor, now known as TRPV1, transient receptor potential (TRP) channels have occupied an important place in the understanding of sensory nerve function in the context of pain. Several TRP channels exhibit sensitivity to substances previously known to cause pain or pain-like sensations; these include
Cortright, Daniel N. +2 more
openaire +3 more sources
Nature Structural & Molecular Biology, 2018 Mammalian transient receptor potential (TRP) channels mediate Ca2+ flux and voltage changes across membranes in response to environmental and cellular signals. At the plasma membrane, sensory TRPs act as neuronal detectors of physical and chemical environmental signals, and receptor-operated (metabotropic) TRPs decode extracellular neuroendocrine cues ...
Xiaoli Zhang +3 more
openaire +2 more sources