Spicy science: David Julius and the discovery of temperature-sensitive TRP channels. [PDF]
, 2015 This invited biographical review covers the career of Dr. David Julius and his discovery of thermosensitive TRP channels. Dr. Julius is currently the Morris Herzstein Chair in Molecular Biology and Medicine and Professor and Chair of Physiology at the ...
Bautista, Diana
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Implementation relations for testing through asynchronous channels [PDF]
, 2012 This paper concerns testing from an input output transition system (IOTS) model of a system under test that interacts with its environment through asynchronous first in first out (FIFO) channels.
Hierons, RM
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Tree-based reparameterization with distributional approximations for reduced-complexity MIMO symbol detection [PDF]
, 2008 Detection of spatially multiplexed data transmissions subject to frequency flat fading is considered. Optimal decoders require knowledge of the marginal posterior distributions of the transmitted symbols, but their exact computation is not feasible for ...
Andrieu, C +3 more
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Involvement of Neural Transient Receptor Potential Channels in Peripheral Inflammation
Frontiers in Immunology, 2020 Transient receptor potential (TRP) channels are a superfamily of non-selective cation channels that act as polymodal sensors in many tissues throughout mammalian organisms.
Harold A. Silverman +11 more
doaj +1 more source
Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids [PDF]
, 2016 Inward rectifier potassium (Kir) channel activity is controlled by plasma membrane lipids. Phosphatidylinositol-4,5-bisphosphate (PIP(2)) binding to a primary site is required for opening of classic inward rectifier Kir2.1 and Kir2.2 channels, but ...
Anna Stary-Weinzinger +55 more
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The Jackprot Simulation Couples Mutation Rate with Natural Selection to Illustrate How Protein Evolution Is Not Random [PDF]
, 2011 Protein evolution is not a random process. Views which attribute randomness to molecular change, deleterious nature to single-gene mutations, insufficient geological time, or population size for molecular improvements to occur, or invoke “design ...
Bai, Chunyan Y. +2 more
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The role of transient receptor potential channels in joint diseases [PDF]
European Cells & Materials, 2017 ransient receptor potential channels (TRP channels) are cation selective transmembrane receptors with diverse structures, activation mechanisms and physiological functions.
O Krupkova, J Zvick, K Wuertz-Kozak
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Sequence and structural conservation reveal fingerprint residues in TRP channels
eLife, 2022 Transient receptor potential (TRP) proteins are a large family of cation-selective channels, surpassed in variety only by voltage-gated potassium channels.
Deny Cabezas-Bratesco +7 more
doaj +1 more source
TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells [PDF]
, 2018 BACKGROUND: Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limited efficacy at maximal tolerated
Ji, Xiaoying +10 more
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Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels.
PLoS ONE, 2023 Transient receptor potential (TRP) channels are activated by various extracellular and intracellular stimuli and are involved in many physiological events.
Manae Tatsumi +8 more
doaj +1 more source