Results 51 to 60 of about 65,940 (289)

Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans. [PDF]

, 2012
BackgroundResponding to noxious stimuli by invoking an appropriate escape response is critical for survival of an organism. The sensations of small and large changes in temperature in most organisms have been studied separately in the context of ...
Ghosh, Rajarshi, Kruglyak, Leonid, Mohammadi, Aylia, Ryu, William S   +3 more
core   +3 more sources

Purification of Functional Human TRP Channels Recombinantly Produced in Yeast

Cells, 2019
(1) Background: Human transient receptor potential (TRP) channels constitute a large family of ion-conducting membrane proteins that allow the sensation of environmental cues.
Liying Zhang, Kaituo Wang, Dan Arne Klaerke, Kirstine Calloe, Lillian Lowrey, Per Amstrup Pedersen, Pontus Gourdon, Kamil Gotfryd   +7 more
doaj   +1 more source

Probing the role of the cation–π interaction in the binding sites of GPCRs using unnatural amino acids [PDF]

, 2009
We describe a general application of the nonsense suppression methodology for unnatural amino acid incorporation to probe drug–receptor interactions in functional G protein-coupled receptors (GPCRs), evaluating the binding sites of both the M2 muscarinic
Ballesteros, Cho, D. A. Dougherty, Dougherty, Dougherty, Dougherty, Doupnik, Gallivan, H. A. Lester, Hibert, Hopkins, Huang, Huang, K. S. Bower, Klabunde, Kofuji, Krapivinsky, Lagerstrom, Lu, Lu, M. M. Torrice, Ma, Mark, Nemeth, Nowak, Palczewski, Rasmussen, Schwartz, Warne, Xiu, Zacharias, Zhong   +31 more
core   +3 more sources

Cannabinoid Ligands Targeting TRP Channels

Frontiers in Molecular Neuroscience, 2019
Transient receptor potential (TRP) channels are a group of membrane proteins involved in the transduction of a plethora of chemical and physical stimuli.
Chanté Muller, Paula Morales, Patricia H. Reggio   +2 more
doaj   +1 more source

Catechol estrogens stimulate insulin secretion in pancreatic β-cells via activation of the transient receptor potential A1 (TRPA1) channel [PDF]

, 2019
Estrogen hormones play an important role in controlling glucose homeostasis and pancreatic β-cell function. Despite the significance of estrogen hormones for regulation of glucose metabolism, little is known about the roles of endogenous estrogen ...
Cabrera, Over, Cerne, Rok, Chen, Xingjuan, Efanov, Alexander M., Ficorilli, James V., Ma, Wenzhen, Obukhov, Alexander G., Syed, Samreen K.   +7 more
core   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

TRPs in Tox: Involvement of Transient Receptor Potential-Channels in Chemical-Induced Organ Toxicity—A Structured Review

Cells, 2018
Chemicals can exhibit significant toxic properties. While for most compounds, unspecific cell damaging processes are assumed, a plethora of chemicals exhibit characteristic odors, suggesting a more specific interaction with the human body.
Dirk Steinritz, Bernhard Stenger, Alexander Dietrich, Thomas Gudermann, Tanja Popp   +4 more
doaj   +1 more source

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source

TRP Channels in Brain Tumors

Frontiers in Cell and Developmental Biology, 2021
Malignant glioma including glioblastoma (GBM) is the most common group of primary brain tumors. Despite standard optimized treatment consisting of extensive resection followed by radiotherapy/concomitant and adjuvant therapy, GBM remains one of the most ...
Giorgia Chinigò, Giorgia Chinigò, Hélène Castel, Hélène Castel, Oana Chever, Oana Chever, Dimitra Gkika, Dimitra Gkika   +7 more
doaj   +1 more source

Structural insights on TRPV5 gating by endogenous modulators. [PDF]

, 2018
TRPV5 is a transient receptor potential channel involved in calcium reabsorption. Here we investigate the interaction of two endogenous modulators with TRPV5.
Carnevale, Vincenzo, Carnevale|, Fluck, Edwin C., Hughes, Taylor E. T., Huynh, Kevin W., Kasimova, Marina A., Kasimova|, Moiseenkova-Bell, Vera Y., Molugu, Sudheer K., Pumroy, Ruth A., Rohacs, Tibor, Samanta, Amrita, Yazici, Aysenur Torun, Zhou, Z. Hong   +13 more
core   +3 more sources