Results 31 to 40 of about 852,547 (280)

Transient Receptor Potential Channels and Inflammatory Bowel Disease

Frontiers in Immunology, 2020
The transient receptor potential (TRP) cation channels are present in abundance across the gastrointestinal (GI) tract, serving as detectors for a variety of stimuli and secondary transducers for G-protein coupled receptors.
Yiding Chen, Yiding Chen, Jingxi Mu, Jingxi Mu, Min Zhu, Min Zhu, Arjudeb Mukherjee, Hu Zhang, Hu Zhang   +8 more
doaj   +1 more source

Role of Chemosensory TRP Channels in Lung Cancer

Pharmaceuticals, 2018
Transient receptor potential (TRP) channels represent a large family of cation channels and many members of the TRP family have been shown to act as polymodal receptor molecules for irritative or potentially harmful substances.
Thomas R. H. Büch, Eva A. M. Büch, Ingrid Boekhoff, Dirk Steinritz, Achim Aigner   +4 more
doaj   +1 more source

Schistosome TRP channels: An appraisal

International Journal for Parasitology: Drugs and Drug Resistance, 2020
Ion channels underlie electrical excitability in cells and are essential for a variety of functions, most notably neuromuscular and sensory activity. They are also validated targets for a preponderance of approved anthelmintic compounds.
Swarna Bais, Robert M. Greenberg
doaj   +1 more source

Inhibition of diacylglycerol–sensitive TRPC channels by synthetic and natural steroids [PDF]

, 2012
TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca2+ signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition have ...
Kleemann, Heinz-Werner, Rütten, Hartmut, Hartmut Rütten (171202), Löhn Matthias, Thorsten Schmidt (5598), Thomas Licher (171199), Löhn, Matthias, Miehe Susanne, Dittrich Werner, Peter Crause, Carsten Strübing (171204), Schmidt, Thorsten, Miehe, Susanne, Susanne Miehe, Schmidt Thorsten, Carsten Strübing, Heinz-Werner Kleemann (171197), Peter Crause (171193), Dittrich, Werner, Licher, Thomas, Hartmut Rütten, Matthias Löhn, Strübing, Carsten, Rütten Hartmut, Matthias Löhn (171195), Strübing Carsten, Werner Dittrich, Licher Thomas, Thomas Licher, Heinz-Werner Kleemann, Werner Dittrich (171200), Kleemann Heinz-Werner, Crause, Peter, Susanne Miehe (171189), Crause Peter, Thorsten Schmidt   +35 more
core   +2 more sources

Drosophila TRPM channel is essential for the control of extracellular magnesium levels [PDF]

, 2010
The TRPM group of cation channels plays diverse roles ranging from sensory signaling to Mg2+ homeostasis. In most metazoan organisms the TRPM subfamily is comprised of multiple members, including eight in humans. However, the Drosophila TRPM subfamily is
Vladimir Chubanov, Craig Montell, Chen, Xiaodi, Xiaodi Chen, Anna S Dietz, Dietz, Anna S., Anna S. Dietz, Chubanov, Vladimir, Thomas Hofmann, Thomas Gudermann, Chen Xiaodi, Hofmann Thomas, Chubanov Vladimir, Dietz Anna S., Montell Craig, Gudermann, Thomas, Gudermann Thomas, Montell, Craig, Hofmann, Thomas   +18 more
core   +2 more sources

Emergence of functional sensory subtypes as defined by transient receptor potential channel expression [PDF]

, 2007
The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception of touch, temperature, and pain. A differential expression of transient receptor potential (TRP)
Hjerling-Leffler, J, Ernfors, P, Ernfors, P,, Koltzenburg, M, AlQatari, M   +4 more
core   +1 more source

The versatility of the putative transient receptor potential ion channels in regulating the calcium signaling in Aspergillus nidulans

mSphere, 2023
Transient receptor potential (TRP) channels are evolutionarily conserved integral membrane proteins. They serve as crucial mediators of sensory signals and have profound effects on cellular functions.
Hongchen Wang, Renwei Gao, Yuanwei Zhang, Ling Lu   +3 more
doaj   +1 more source

Nociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain Pathologies

Pharmaceuticals, 2016
Specialized receptors belonging to the transient receptor potential (TRP) family of ligand-gated ion channels constitute the critical detectors and transducers of pain-causing stimuli.
Aaron D. Mickle, Andrew J. Shepherd, Durga P. Mohapatra   +2 more
doaj   +1 more source

Functional Importance of Transient Receptor Potential (TRP) Channels in Neurological Disorders

Frontiers in Cell and Developmental Biology, 2021
Transient receptor potential (TRP) channels are transmembrane protein complexes that play important roles in the physiology and pathophysiology of both the central nervous system (CNS) and the peripheral nerve system (PNS).
Kihwan Lee, Youn Yi Jo, Gehoon Chung, Jung Hoon Jung, Yong Ho Kim, Chul-Kyu Park   +5 more
doaj   +1 more source

Trp channels and itch [PDF]

Seminars in Immunopathology, 2015
Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex plays a protective role in daily life by removing irritants, chronic itch remains a clinical challenge. Despite urgent clinical need, itch has received relatively little research attention and its mechanisms have remained poorly understood until recently.
Shuohao, Sun, Xinzhong, Dong
openaire   +2 more sources