Results 11 to 20 of about 2,580,555 (203)

Self-organized enhancement of conductivity in biological ion channels [PDF]

, 2013
We discuss an example of self-organization in a biological system. It arises from long-range ion–ion interactions, and it leads us to propose a new kind of enhanced conduction in ion channels.
Kaufman, Igor, Khovanov, I. A., Khovanov, Igor A., McClintock, P. V. E., Eisenberg, Robert S., Luchinsky, Dmittri G., McClintock, Peter V. E., Eisenberg, R. S., Luchinsky, Dmitrii G., Tindjong, Rodrigue   +9 more
core   +6 more sources

Non-equilibrium stochastic dynamics of open ion channels [PDF]

, 2013
We present and discuss a modified version of reaction rate theory (RRT) to describe the passage of a positive ion through a biological ion channel. It takes explicit account of the non-equilibrium nature of the permeation process. Unlike traditional RRT,
Kaufman, Igor, Khovanov, Igor A., McClintock, Peter V. E., Eisenberg, R. S., Luchinsky, Dmitrii G., Tindjong, Rodrigue   +5 more
core   +4 more sources

Charge fluctuations and boundary conditions of biological ion channels : effect on the ionic transition rate [PDF]

, 2009
A self-consistent solution is derived for the Poisson-Nernst-Planck (PNP) equation, valid both inside a biological ion channel and in the adjacent bulk fluid. An iterative procedure is used to match the two solutions together at the channel mouth. Charge
Luchinsky, D. G., McClintock, P. V. E., Eisenberg, R. S., Tindjong, R.   +3 more
core   +4 more sources

Ion trapping with fast-response ion-selective microelectrodes enhances detection of extracellular ion channel gradients [PDF]

, 2008
Previously, functional mapping of channels has been achieved by measuring the passage of net charge and of specific ions with electrophysiological and intracellular fluorescence imaging techniques.
Collis, Leon P., Smith, Peter J. S., Messerli, Mark A., Smith, Peter J.S.   +3 more
core   +1 more source

Definition of two agonist types at the mammalian cold-activated channel TRPM8

eLife, 2016
Various TRP channels act as polymodal sensors of thermal and chemical stimuli, but the mechanisms whereby chemical ligands impact on TRP channel gating are poorly understood.
Annelies Janssens, Maarten Gees, Balazs Istvan Toth, Debapriya Ghosh, Marie Mulier, Rudi Vennekens, Joris Vriens, Karel Talavera, Thomas Voets   +8 more
doaj   +1 more source

Functional expression of CLIFAHDD and IHPRF pathogenic variants of the NALCN channel in neuronal cells reveals both gain- and loss-of-function properties

Scientific Reports, 2019
The excitability of neurons is tightly dependent on their ion channel repertoire. Among these channels, the leak sodium channel NALCN plays a crucial role in the maintenance of the resting membrane potential.
Malik Bouasse, Hathaichanok Impheng, Zoe Servant, Philippe Lory, Arnaud Monteil   +4 more
doaj   +1 more source

Lipid ion channels [PDF]

Biophysical Chemistry, 2010
Review
openaire   +4 more sources

VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8

Nature Communications, 2016
The temperature-sensitive TRPM8 channel is essential for cold sensing and has been linked to pathological cold hypersensitivity. Here, the authors find TRPM8 insertion in the cell membrane is mediated by VAMP7 following atypical LAMP1-containing vesicle ...
Debapriya Ghosh, Silvia Pinto, Lydia Danglot, Ine Vandewauw, Andrei Segal, Nele Van Ranst, Melissa Benoit, Annelies Janssens, Rudi Vennekens, Pieter Vanden Berghe, Thierry Galli, Joris Vriens, Thomas Voets   +12 more
doaj   +1 more source

Activity-dependent regulation of T-type calcium channels by submembrane calcium ions

eLife, 2017
Voltage-gated Ca2+ channels are involved in numerous physiological functions and various mechanisms finely tune their activity, including the Ca2+ ion itself.
Magali Cazade, Isabelle Bidaud, Philippe Lory, Jean Chemin   +3 more
doaj   +1 more source

The diverse roles of TMEM16A Ca2+-activated Cl− channels in inflammation

Journal of Advanced Research, 2021
Background: Transmembrane protein 16A (TMEM16A) Ca2+-activated Cl− channels have diverse physiological functions, such as epithelial secretion of Cl− and fluid and sensation of pain.
Weiliang Bai, Mei Liu, Qinghuan Xiao
doaj   +1 more source