Results 41 to 50 of about 46,486 (306)
Palmitoylation of Voltage-Gated Ion Channels
International Journal of Molecular Sciences, 2022 Protein lipidation is one of the most common forms of posttranslational modification. This alteration couples different lipids, such as fatty acids, phospho- and glycolipids and sterols, to cellular proteins. Lipidation regulates different aspects of the protein’s physiology, including structure, stability and affinity for cellular membranes and ...
Silvia Cassinelli +5 more
openaire +2 more sources
Theoretical implication of liganding reactions in axonal sodium channel gating
, 1980 Dorogi PL, Neumann E. Theoretical implication of liganding reactions in axonal sodium channel gating. Neurochemistry International. 1980;2:45-51.Mathematical simulation models for measured permeability properties of axonal Na+ channels point to the ...
Dorogi, Peter L., Neumann, Eberhard
core +2 more sources
, 2010 CFTR, the ABC protein defective in cystic fibrosis, functions as an anion channel. Once phosphorylated by protein kinase A, a CFTR channel is opened and closed by events at its two cytosolic nucleotide binding domains (NBDs).
Gadsby, David C. +5 more
core +1 more source
A nomenclature for ligand-gated ion channels [PDF]
Neuropharmacology, 2009 The ligand-gated ion channels that participate in fast synaptic transmission comprise the nicotinic acetylcholine, 5-hydroxytryptamine3 (5-HT3), gamma-aminobutyric acidA (GABA(A)), glycine, ionotropic glutamate and P2X receptor families. A consistent and systematic nomenclature for the individual subunits that comprise these receptors and the receptors
Collingridge, GL +3 more
openaire +3 more sources
Molecular simulations of ion channel gating
, 2022 Ion channels are membrane proteins that facilitate ion permeation across the membrane down the concentration gradient. Recently, many structures of the ion channels were solved using cryo-electron microscopy.
Pipatpolkai, Tanadet
core +2 more sources
Distinct gating mechanisms revealed by the structures of a multi-ligand gated K+ channel
eLife, 2012 The gating ring-forming RCK domain regulates channel gating in response to various cellular chemical stimuli in eukaryotic Slo channel families and the majority of ligand-gated prokaryotic K+ channels and transporters.
Chunguang Kong +7 more
doaj +1 more source
Flexibility of the N-Terminal mVDAC1 Segment Controls the Channel’s Gating Behavior
, 2012 Since the solution of the molecular structures of members of the voltage dependent anion channels (VDACs), the N-terminal α-helix has been the main focus of attention, since its strategic location, in combination with its putative conformational ...
Grosse, Wolfgang +23 more
core +1 more source
Identification of putative potassium channel homologues in pathogenic protozoa [PDF]
, 2012 K(+) channels play a vital homeostatic role in cells and abnormal activity of these channels can dramatically alter cell function and survival, suggesting that they might be attractive drug targets in pathogenic organisms.
Prole, D L +3 more
core +1 more source
A binding-block ion selective mechanism revealed by a Na/K selective channel
Protein & Cell, 2017 Mechanosensitive (MS) channels are extensively studied membrane protein for maintaining intracellular homeostasis through translocating solutes and ions across the membrane, but its mechanisms of channel gating and ion selectivity are largely unknown ...
Jie Yu +9 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source