Results 11 to 20 of about 26,356 (209)
Purinergic Signaling in Spermatogenesis
Frontiers in Endocrinology, 2022 Adenosine triphosphate (ATP) serves as the essential source of cellular energy. Over the last two decades, however, ATP has also attracted increasing interest as an extracellular signal that activates purinergic plasma membrane receptors of the P2 family.
Nadine Mundt +5 more
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Purinergic Signaling in Neuroinflammation [PDF]
International Journal of Molecular Sciences, 2021 ATP is stored in millimolar concentrations within the intracellular medium but may be released to extracellular sites either through the damaged plasma membrane or by means of various transporters [...]
Dmitry Aminin, Peter Illes
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Purinergic Signaling in Ovarian Carcinoma. [PDF]
Adv Pharm BullOvarian carcinoma (OC) is the most lethal gynecological cancer worldwide. Around 95% of patients exhibit recurrence five years after treatment; 80% experience recurrence within 18 months after first-line treatment, and progression-free survival rates have not changed over the past 40 years. New therapeutic approaches are imperative to face this complex
Martínez-Ramírez AS +4 more
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Purinergic signalling in bone [PDF]
Frontiers in Endocrinology, 2012 Purinergic signaling in bone was first proposed in the early 1990s with the observation that extracellular ATP could modulate events crucial to the normal functioning of bone cells. Since then the expression of nearly all the P2Y and P2X receptors by osteoblasts and osteoclasts has been reported, mediating multiple processes including cell ...
Rumney, Robin M.H. +3 more
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Purinergic Signalling in the Cochlea
International Journal of Molecular Sciences, 2022 The mammalian cochlea is the sensory organ of hearing with a delicate, highly organised structure that supports unique operating mechanisms. ATP release from the secretory tissues of the cochlear lateral wall (stria vascularis) triggers numerous physiological responses by activating P2 receptors in sensory, supporting and neural tissues.
Srdjan M. Vlajkovic, Peter R. Thorne
openaire +2 more sources
Purinergic Signaling in Bone [PDF]
Journal of Osteoporosis, 2013 In recent years, it has become apparent that extracellular nucleotides, signalling via P2 receptors, play an important role in the regulation of bone turnover. Furthermore, purinergic signalling has been associated in the pathophysiology of several bone and cartilage diseases, including osteoarthritis, rheumatoid arthritis, and osteoporosis and might ...
Niklas Rye Jørgensen +3 more
doaj +4 more sources
Purinergic signalling and cancer [PDF]
Purinergic Signalling, 2013 Receptors for extracellular nucleotides are widely expressed by mammalian cells. They mediate a large array of responses ranging from growth stimulation to apoptosis, from chemotaxis to cell differentiation and from nociception to cytokine release, as well as neurotransmission.
Burnstock G, DI VIRGILIO, Francesco
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The Role of Purinergic Signaling in Heart Transplantation
Frontiers in Immunology, 2022 Heart transplantation remains the optimal treatment option for patients with end-stage heart disease. Growing evidence demonstrates that purinergic signals mediated by purine nucleotides and nucleosides play vital roles in heart transplantation ...
Yanzhi Jiang +3 more
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Mitochondria Synergize With P2 Receptors to Regulate Human T Cell Function
Frontiers in Immunology, 2020 Intracellular ATP is the universal energy carrier that fuels many cellular processes. However, immune cells can also release a portion of their ATP into the extracellular space.
Carola Ledderose, Wolfgang G. Junger
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Purinergic signaling in the male reproductive tract
Frontiers in Endocrinology, 2022 Purinergic receptors are ubiquitously expressed throughout the body and they participate in the autocrine and paracrine regulation of cell function during normal physiological and pathophysiological conditions.
Larissa Berloffa Belardin +4 more
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